Ventilator-Associated Pneumonia and Causative Microorganisms in Intensive Care Unit: A Two Year Retrospective Analysis

Palabıyık, Onur; Öğütlü, Aziz; Toptaş, Yaşar

doi:10.4274/tybdd.60490

Cited by 7 publications

(5 citation statements)

References 8 publications

(10 reference statements)

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“…In various studies evaluating the length of stay of patients with VAP in intensive care units, different results were obtained reporting the average length of stay between 21 and 76 days (10)(11)(12). In our study, the mean hospitalization period of the patients in Group 1 was 37.66±14.36 days (min-max: 10-75 days), and the mean hospitalization period of the patients in Group 2 was 35.05±16.09 days (min-max: 9-85 days) and the values were found to conform with the literature.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Patients with Ventilator-Associated Pneumonia Developed in Two Different Intensive Care Units of a Tertiary Hospital

UGUZ>

Karasu

Yılmaz

et al. 2022

Batı Karadeniz Tıp Dergisi

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Aim: Our purpose is to compare the characteristics and 30-day mortality of ventilator-associated pneumonia (VAP) patients that developed in two different intensive care units (ICUs) in a tertiary hospital. Material and Methods: Patients who were over the age of 18 who developed VAP in two different ICUs of our hospital over two years were included in the study. Acute Physiology and Chronic Health Assessment II (APACHE II), Sepsis-Related Organ Failure Assessment (SOFA), Glasgow Coma Score (GCS), Clinical Pulmonary Infection Score (CPIS), infection markers, and 30-day mortality of the patients were evaluated. Physical conditions of Group 1 and Group 2, hand hygiene rates in ICU, nurse education level, and hospitalization rate in intensive care units were compared. Results: A total of 104 patients, 48 being in Group 1 and 56 being in Group 2, were analyzed. There was no significant difference between the two groups with regards of GKS, SOFA and CPIS scores. Acinetobacter baumanni was the most common agent in both groups. The hospitalization rate was found to be significantly higher in Group 2. 30-day mortality was 45.8% in Group 1 and 48.2% in Group 2. It was found that a one unit increase in the SOFA hospitalization period reduced the risk of 30-day mortality. It was determined that a one unit increase in the age ratio in Group 2 increased the risk of 30-day mortality 1.085 times, and the increase in the mean SOFA score in all patients and Group 1 decreased the length of the hospitalization period. Conclusion: We found a 30-day mortality rate of 47.1% in patients diagnosed with VAP. An increase in SOFA score increases the risk of 30-day mortality, while a prolonged hospitalization period decreases the risk of mortality.

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Section: Discussionmentioning

confidence: 99%

Comparison of Patients with Ventilator-Associated Pneumonia Developed in Two Different Intensive Care Units of a Tertiary Hospital

UGUZ>

Karasu

Yılmaz

et al. 2022

Batı Karadeniz Tıp Dergisi

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“…In the studies, Gram-negative bacteria have been reported as the most common isolates in VAP patients. Among these, the most common bacteria are Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae (19)(20)(21)(22)(23)(24)(25)(26)(27)(28) . In our study, the microorganisms caused VAP were similar to those studies regarding their order of frequency (Figure 1).…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and the Risk Factors for Mortality in Ventilator-Associated Pneumonia

Yeşilbağ¹,

Şeker²

2020

BMJ

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Objective: Ventilator-associated pneumonia (VAP) is the most common hospital-aquired infections in intensive care units (ICUs) and associated with prolonged hospital stay, increased mortality and cost. This study aims to analyse the epidemiology and the risk factors affecting 30 day-mortality in VAP. Method: Adult patients with VAP were included in the study. Data were obtained from infection control commitee records. Patients were followed up for mortality until 30 days after onset of VAP or until death for the patients died within 30 days. Survivor and non-survivor groups were compared as for the predictors of mortality.

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“…üredi. Ülkemizde yapılan çalışmalarda, VİP etkeni olarak; Acinetobacter baumannii, Pseudomonas aeruginosa, K. pneumoniae ve Enterobacter cloacae gibi Gram-negatif bakterilerin ön planda olduğu, Gram-pozitif bakterilerde ise en sık S. aureus'un izole edildiği bildirilmiştir (22)(23)(24).…”

Section: Yöntemlerunclassified

Investigation of Microbial Etiology in Endotracheal Aspirate Samples of Severe Pneumonia Patients by Multiplex PCR and Culture Method

Karakök¹,

CESUR

Kılıç

et al. 2022

Klimik Derg

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Objectives: The probability of detecting viral and atypical agents in pneumonia patients has increased with the molecular methods used in recent years. We aimed to investigate pneumonia pathogens in endotracheal aspiration samples (ETA) of patients with severe community-acquired (CAP), hospital-acquired pneumonia (HAP), and ventilator-associated pneumonia (VAP) by multiplex polymerase chain reaction (m-PCR) and culture method. Methods: A prospective study was performed between December 2019 and October 2020. Patients 18 years and older with pneumonia followed in ICU on the mechanical ventilator were included. COVID-19 patients were excluded. Patients were grouped as CAP, HAP, and VAP. Two ETA samples were obtained from patients within 48 hours of the pneumonia diagnosis. Respiratory pathogens were investigated in samples by viral-bacterial m-PCR and bacterial culture methods. Results: 74 patients were included in the study. m-PCR of ETA samples achieved pathogen detection in 87.8% of patients compared with 58.1% with culture methods. The most common pathogen detected by m-PCR was Streptococcus pneumoniae in both CAP and HAP patients and Klebsiella spp. in VAP patients. The most common pathogen isolated by culture was Staphylococcus aureus in both CAP and HAP patients and Klebsiella spp. in VAP patients. Atypical pneumonia pathogens were positive for 14.9% of the patients. Atypical pathogens were recovered from 28.5% of CAP patients and 23.1% of HAP patients. Viruses constituted all of the atypical pathogens recovered from HAP patients. No atypical pathogen was found in VAP patients. Conclusion: In this study, S. pneumoniae was the most common pathogen detected with m-PCR, and S. aureus and Klebsiella spp. were the most common pathogens detected with culture. Determination of microbial etiology of lower respiratory tract samples by molecular methods for diagnosing severe CAP and HAP may be beneficial in terms of treatment. Keywords: pneumonia, multiplex PCR, endotracheal aspirate, conventional methods

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Ventilator-Associated Pneumonia and Causative Microorganisms in Intensive Care Unit: A Two Year Retrospective Analysis

Cited by 7 publications

References 8 publications

Comparison of Patients with Ventilator-Associated Pneumonia Developed in Two Different Intensive Care Units of a Tertiary Hospital

Comparison of Patients with Ventilator-Associated Pneumonia Developed in Two Different Intensive Care Units of a Tertiary Hospital

Epidemiology and the Risk Factors for Mortality in Ventilator-Associated Pneumonia

Investigation of Microbial Etiology in Endotracheal Aspirate Samples of Severe Pneumonia Patients by Multiplex PCR and Culture Method

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