Ventilator-associated events in children: A multicentre prospective cohort study

Ventilator-associated events: From surveillance to optimizing management

“…Conversely, in a multicenter prospective study conducted by 15 Spanish PICUs, the pediatric definition of VAE based on slighter PEEP increases (PEEP-PedVAE) was the least restrictive, and it was the only VAE definition that was independently associated with increased MV and length of ICU stay in children. [ 45 ] In another study, all VAE algorithms (PEEP-PedVAE, MAP-PedVAE, and adult VAE) were associated with adverse outcomes, including higher mortality rates when retrospectively applied in a pediatric population. [ 46 ] Thus, a unified PedVAE definition is needed.…”

“…[ 8 ] Computerized VAE surveillance reduces time and effort and limits the risk of operator bias. [ 45 , 48 ] Shenoy et al [ 49 ] compared automated vs. manual surveillance and found an increase in sensitivity and positive predictive value (40% vs. 71% and 70% vs. 87%) using completely automated models. Frequent errors in the manual surveillance cohort were missed detections, false detections, and misclassification.…”