Ventilation strategies in the depressed term infant

Boyle, David W.; Szyld, Edgardo; Field, David

doi:10.1016/j.siny.2008.04.026

Cited by 10 publications

(5 citation statements)

References 63 publications

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“…As these infants have liquid-filled lungs, the airways must be cleared of liquid to establish pulmonary gas exchange and restore spontaneous circulation 1 2. Currently, there is no globally accepted strategy for the resuscitation of asphyxiated newborn infants.…”

Section: Introductionmentioning

confidence: 99%

The effect of oxygen content during an initial sustained inflation on heart rate in asphyxiated near-term lambs

Sobotka

Ong

Polglase

et al. 2015

Arch Dis Child Fetal Neonatal Ed

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Section: Introductionmentioning

confidence: 99%

The effect of oxygen content during an initial sustained inflation on heart rate in asphyxiated near-term lambs

Sobotka

Ong

Polglase

et al. 2015

Arch Dis Child Fetal Neonatal Ed

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“…Successful resuscitation of bradycardic, apnoeic neonates requires adequate ventilation 1 2. The optimal ventilation strategy immediately after birth, when the lungs are liquid-filled, has not been determined.…”

Section: Introductionmentioning

confidence: 99%

Effect of sustained inflation duration; resuscitation of near-term asphyxiated lambs

Klingenberg

Sobotka

Ong

et al. 2012

Arch Dis Child Fetal Neonatal Ed

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“…Infants born severely asphyxic are usually bradycardic and apneic and require some form of assisted ventilation at birth. As these infants are born with liquid-filled lungs, the airways must be cleared of liquid to establish pulmonary gas exchange and to decrease pulmonary vascular resistance [ 1 , 2 ]. Currently, there is no globally accepted strategy for the resuscitation of asphyxiated newborns.…”

Section: Introductionmentioning

confidence: 99%

Single Sustained Inflation followed by Ventilation Leads to Rapid Cardiorespiratory Recovery but Causes Cerebral Vascular Leakage in Asphyxiated Near-Term Lambs

et al. 2016

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BackgroundA sustained inflation (SI) rapidly restores cardiac function in asphyxic, bradycardic newborns but its effects on cerebral haemodynamics and brain injury are unknown. We determined the effect of different SI strategies on carotid blood flow (CaBF) and cerebral vascular integrity in asphyxiated near-term lambs.MethodsLambs were instrumented and delivered at 139 ± 2 d gestation and asphyxia was induced by delaying ventilation onset. Lambs were randomised to receive 5 consecutive 3 s SI (multiple SI; n = 6), a single 30 s SI (single SI; n = 6) or conventional ventilation (no SI; n = 6). Ventilation continued for 30 min in all lambs while CaBF and respiratory function parameters were recorded. Brains were assessed for gross histopathology and vascular leakage.ResultsCaBF increased more rapidly and to a greater extent during a single SI (p = 0.01), which then decreased below both other groups by 10 min, due to a higher cerebral oxygen delivery (p = 0.01). Blood brain barrier disruption was increased in single SI lambs as indicated by increased numbers of blood vessel profiles with plasma protein extravasation (p = 0.001) in the cerebral cortex. There were no differences in CaBF or cerebral oxygen delivery between the multiple SI and no SI lambs.ConclusionsVentilation with an initial single 30 s SI improves circulatory recovery, but is associated with greater disruption of blood brain barrier function, which may exacerbate brain injury suffered by asphyxiated newborns. This injury may occur as a direct result of the initial SI or to the higher tidal volumes delivered during subsequent ventilation.

show abstract

Ventilation strategies in the depressed term infant

Cited by 10 publications

References 63 publications

The effect of oxygen content during an initial sustained inflation on heart rate in asphyxiated near-term lambs

The effect of oxygen content during an initial sustained inflation on heart rate in asphyxiated near-term lambs

Effect of sustained inflation duration; resuscitation of near-term asphyxiated lambs

Single Sustained Inflation followed by Ventilation Leads to Rapid Cardiorespiratory Recovery but Causes Cerebral Vascular Leakage in Asphyxiated Near-Term Lambs

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