VENTILATION IMAGING WITH EASILY PREPARED 99mTc AEROSOLS

Francis, R. A.; Agnew, J. E.; Sutton, Philip P.; Pavia, D; Clarke, S W

doi:10.1097/00006231-198108000-00002

Cited by 16 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Their main use is to image lung ventilation, thus aiding the diagnosis of pulmonary embolism (Francis et al 1981;Buxton-Thomas and Wraight 1984). Aerosols have replaced the use of radioactive gases such as krypton 81m and xenon 133 in some centres.…”

Section: Introductionmentioning

confidence: 99%

The APE nebuliser — a new delivery system for the alveolar targeting of particulate technetium 99m diethylene triamine penta-acetic acid

et al. 1991

View full text Add to dashboard Cite

We report the validation of a new delivery system--aerosol production equipment (known by the acronym APE), which generates a particulate aerosol of technetium 99m diethylene triamine penta-acetic acid (DTPA) with a mass-median aerodynamic diameter of 0.35 microns and a geometric standard deviation of 1.8 Twenty subjects were studied; in group 1 were 12 healthy men with normal spirometry; in group 2 were 8 men with AIDS who had mildly abnormal lung function following an episode of pneumocystis pneumonia-spirometry FEV1 3.08 (0.73) L, FVC 4.83 (0.82) L [mean (SD)]. The APE nebulizer was used to form a particulate aerosol with 200 MBq of 99mTc DTPA, which was collected in a 35 1 reservoir of air, which was subsequently inhaled. The mean (SD) inhalation time was 4.7 (0.44) min. The output of the nebulizer (% of activity inhaled) was 82%. Using planar imaging, the penetration index (right lung) in group 1 was 0.93 (0.18), mean (SD), and in group 2 it was 0.91 (0.12). There was virtually no tracheal deposition and extrapulmonary deposition (oropharynx and stomach) was less than 5% of the aerosol delivered. Single-photon emission tomography (SPET) studies carried out in five patients from group 1 confirmed homogeneous intrapulmonary deposition of 99mTc-DTPA. In view of the excellent intrapulmonary deposition of 99mTc-DTPA produced by the APE nebulizer, it may provide an alternative to conventional ventilation studies using radioactive gases.

show abstract

Section: Introductionmentioning

confidence: 99%

The APE nebuliser — a new delivery system for the alveolar targeting of particulate technetium 99m diethylene triamine penta-acetic acid

et al. 1991

View full text Add to dashboard Cite

show abstract

Radioaerosols: Production and Characteristics

Francis¹,

Agnew²,

Clarke³

1986

Progress in Radiopharmacy

View full text Add to dashboard Cite

A simple radioaerosol generator and delivery system for pulmonary ventilation studies

et al. 1984

View full text Add to dashboard Cite

Details of a simple radioaerosol generator and delivery system are presented. Aerosol streams of 99mTc-DTPA solution of different distributions were produced. The most useful distribution had an activity median aerodynamic diameter (AMAD) of 0.9 micron with a geometric standard deviation of 1.5. This distribution also had more than 96% of aerosol particles with aerodynamic diameter less than 2 micron. The system has been used for patient lung ventilation studies. The aerosol breathing-in period to achieve a satisfactory count rate was 1.8 +/- 0.38 min. The radioaerosol images were excellent and comparable to those obtained with 81mKr gas.

show abstract

VENTILATION IMAGING WITH EASILY PREPARED 99mTc AEROSOLS

Cited by 16 publications

References 0 publications

The APE nebuliser — a new delivery system for the alveolar targeting of particulate technetium 99m diethylene triamine penta-acetic acid

The APE nebuliser — a new delivery system for the alveolar targeting of particulate technetium 99m diethylene triamine penta-acetic acid

Radioaerosols: Production and Characteristics

A simple radioaerosol generator and delivery system for pulmonary ventilation studies

Contact Info

Product

Resources

About