Ventilação líquida: revisão da literatura

Andrade, Cristiano Feijó; Fortis, Elaine Aparecida Felix; Cardoso, Paulo Francisco Guerreiro

doi:10.1590/s0102-35862002000600011

Cited by 1 publication

(2 citation statements)

References 83 publications

(106 reference statements)

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“…The rationale for using PFC is mostly to protect the lungs once lung injury has been established [ 19 , 23 , 26 , 40 ]. Based on such observations and the results of the present study, which suggests that the PFC can also be used before the onset of severe lung injury, lung transplantation can be a suitable model in which the PFC can provide both graft protection and IR injury reduction.…”

Section: Discussionmentioning

confidence: 99%

“…Liquid perfluorocarbons (PFCs) administered endobronchially have been used in different models of lung injury [ 22 , 23 ], primarily as an alternative method of lung ventilation, known as partial liquid ventilation [ 19 ]. PFCs wash out alveoli debris, recruit collapsed alveoli, improve gas exchange, protect pulmonary architecture and have anti-inflammatory and antioxidant properties [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Endobronchial Perfluorocarbon Reduces Inflammatory Activity before and after Lung Transplantation in an Animal Experimental Model

Forgiarini

Holand

Forgiarini

et al. 2013

Mediators of Inflammation

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Background. The aim of this study was to evaluate the use of liquid perfluorocarbon (PFC) as an adjuvant substance for lung preservation and assess its role in pulmonary protection after transplantation. Methods. Seventy-two rat lungs were flushed with low-potassium dextran (LPD) solution and randomized into three main groups: control with LPD alone and experimental with 3 (PFC3) and 7 mL/kg (PFC7) of endobronchial PFC instilled just after harvest. Each group was divided into four subgroups according to preservation time (3, 6, 12, and 24 hours). Afterwards, we performed lung transplantation using rat lungs preserved for 12 hours with LPD alone or with 7 mL/kg of endobronchial PFC. Results. There was a significant increase in oxidative stress in the control group at 6 h of cold ischemic time compared with the PFC3 and PFC7 groups. The apoptotic activity and NF-κB expression were significantly higher in the control group compared with the PFC groups at 3, 12, and 24 h of cold preservation. After transplantation, the NF-κB, iNOS, and nitrotyrosine expression as well as caspase 3 activity were significantly lower in the PFC groups. Conclusion. The use of endobronchial PFC as an adjuvant to the current preservation strategy improved graft viability.

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