Venous Thrombosis and Obscure Visceral Carcinoma

Perlow, Samuel; Daniels, Jordan L.

doi:10.1001/archinte.1956.00250200060004

Cited by 29 publications

(8 citation statements)

References 7 publications

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“…1 Numerous clinical observations suggest that the hemostatic system is frequently activated in cancer patients. [2][3][4][5] Many tumor types have been shown to express TF. 6,7 Further, the level of TF expression in various tumor types has been shown to correlate with their metastatic potential.…”

Section: Introductionmentioning

confidence: 99%

Tissue factor-factor VIIa–specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration

Hjortoe

Petersen

Albrektsen

et al. 2004

Blood

246

241

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Tissue factor (TF), the cellular receptor for factor VIIa (FVIIa), besides initiating blood coagulation, is believed to play an important role in tissue repair, inflammation, angiogenesis, and tumor metastasis. Like TF, the chemokine interleukin-8 (IL-8) is shown to play a critical role in these processes. To elucidate the potential mechanisms by which TF contributes to tumor invasion and metastasis, we IntroductionCells that express tissue factor (TF) are usually not exposed to the blood. However, in normal response to vessel injury, TF exposure is an initial event of a strictly regulated process resulting in fibrin deposition, inflammation, angiogenesis, and tissue repair. Carcinomas exploit a normal physiologic response in a way that allows tumor growth and dissemination. It has long been presumed that tumors may take advantage of the hemostatic system. A relationship between increased clotting and malignancy was recognized more than a century ago. 1 Numerous clinical observations suggest that the hemostatic system is frequently activated in cancer patients. 2-5 Many tumor types have been shown to express TF. 6,7 Further, the level of TF expression in various tumor types has been shown to correlate with their metastatic potential. [8][9][10] Studies carried out with mouse tumor metastasis models establish that TF plays a critical role in tumor metastasis. 11,12 TF is the cellular receptor for coagulation factor VIIa (FVIIa). TF-induced metastasis requires participation of the cytoplasmic tail of TF and assembly of an active TF-FVIIa complex, 13,14 indicating a dual function for TF in tumor metastasis. The TF cytoplasmic domain, through its specific interaction with ABP-280, has been shown to support cell adhesion and migration. 15 At present it is unclear how TF on tumor cells contributes to tumor metastasis and whether the TF-FVIIa complex plays a direct role or whether its sole requirement is for the downstream generation of active coagulation factors, particularly thrombin, which have been implicated in tumor metastasis. [16][17][18] Recent studies show that proteolytic hydrolysis mediated by the TF-FVIIa complex induces cell signaling through G-proteincoupled receptors in a number of cell types (for reviews, see Prydz et al, 19 Pendurthi and Rao, 20 Ruf et al 21 ). TF-FVIIa-induced signaling in various cell types was shown to alter the expression of specific genes that encode transcription factors, growth factors, and proteins related to cellular reorganization. [22][23][24][25][26][27] These studies suggest that TF-FVIIa-induced signaling may play a role in growthpromoting settings, such as wound healing and cancer. However, it has yet to be shown how TF-FVIIa-induced regulation of gene expression actually affects cell phenotype or pathophysiologic processes. Moreover, a considerable overlap in signaling induced by TF-FVIIa and various other proteases, especially a highmagnitude response generated by thrombin, raises a valid question about the potential significance of TF-FVIIa-induced signaling in path...

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Section: Introductionmentioning

confidence: 99%

Tissue factor-factor VIIa–specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration

Hjortoe

Petersen

Albrektsen

et al. 2004

Blood

246

241

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“…Despite of the mean ob servation period of 8 years, no carcinoma was detected in the present series. This finding contrasts with the increased incidence of recurrent deep vein thrombosis in cancer patients [4]. 21 patients smoked more than 10 cigarettes per day, three less than 10, and five were nonsmokers.…”

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confidence: 64%

Phlebitis saltans, Symptom or Disease Entity?

Bollinger¹,

Leu²

1975

Pathobiology

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“…A disposition to phlebothrombosis in the course of a malignant Various studies have shown that phlebothromboses occur far more frequently in persons who die of malignant neoplasms than in control groups with a non-neoplastic primary disease. In clinical practice they even appear occasionally as the initial symptom [51,60,. In a mixed group of 337 patients with thrombosis of crural, femoral or pelvic veins, Feigl and Schwarz [25] found a neoplastic primary disease in 43.7 % of the cases, whereas in a control group with cardiovascular disease only 21.6% of the patients were found to have this condition.…”

Section: Thrombosis As Paraneoplastic Syndromementioning

confidence: 99%

“…Overall, however, only a minor role is played by mechanical obstruction, proliferation of tumorous tissue into the veins, and hence tumor cell embolisms, or by prolonged immobilization with hypocirculation and the decreased removal of the products of latent coagulation, resulting in a procoagulant effect [25,30,32,33,60,61]. The infiltration of micrometastases through the bloodstream into the lungs is usually accompanied by microthrombotic embolization [26].…”

Section: Possible Causes Local Factors and Microthrombotic Embolizationmentioning

confidence: 99%

Pulmonary embolism and cancer: Predisposition to venous thrombosis and embolism as a paraneoplastic syndrome

Sons

1989

Journal of Surgical Oncology

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In patients with a malignant primary disease the risk of thromboembolic complication is demonstrably increased. This is undoubtedly attributable to a whole range of factors (multifactorial etiology) which are highlighted in the present synoptic study. In addition to local influences from the tumor, a particular role appears to be played by an increased aggregation of thrombocytes, various tumor cell products, polyglobulism, hypercalcemia, increased release of thrombocinase, microthrombotic embolization, and a decrease in antithrombin III.

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Venous Thrombosis and Obscure Visceral Carcinoma

Cited by 29 publications

References 7 publications

Tissue factor-factor VIIa–specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration

Tissue factor-factor VIIa–specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration

Phlebitis saltans, Symptom or Disease Entity?

Pulmonary embolism and cancer: Predisposition to venous thrombosis and embolism as a paraneoplastic syndrome

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