Venous thromboembolism syndrome in gynecological cancer

Wang, X.; Fu, Siqing; Freedman, Ralph S.; Kavanagh, John J.

doi:10.1111/j.1525-1438.2006.00515.x

Cited by 20 publications

(7 citation statements)

References 130 publications

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“…In this study we observed approximately a two-fold increase in the level of cadmium in blood of the smokers in all the examined groups over the non-smokers. However, the mean BCd IJOMEH 2013;26(2) 298 parameter that can gauge ongoing fibrin formation and degradation in some diseases, including ovarian cancer [29,45]. In our research, like in von Tempelhoff et al study [19] we have shown a two-fold increase of fibrin D-dimer plasma level, which correlated with fibrinogen level, in the women with endometrial cancer as compared to the control group.…”

Section: Discussionsupporting

confidence: 67%

“…This may suggest that cadmium exerts toxic effect on the vascular endothelium leading to hypercoagulability. However, it has been observed that coagulation factors and regulatory proteins are upregulated in the patients with gastric cancer [27], colorectal cancer [28], gynecological cancer [29], and cervical cancer [30]. However, there are no studies on women with myoma, except for some data in literature from the 1960s [31].…”

Section: Discussionmentioning

confidence: 99%

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The effect of cadmium on the coagulation and fibrinolytic system in women with uterine endometrial cancer and myoma

Nasiadek¹,

Kilanowicz²,

Daragó³

et al. 2013

International Journal of Occupational Medicine and Environmental Health

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Objectives: Cadmium (Cd) is a persistent and widespread environmental pollutant, which may constitute a potential risk factor for hormone-dependent tumors such as endometrial cancer. The vascular endothelium is an important target of cadmium toxicity, which may interfere with the coagulation cascade and fibrinolytic system. The aim of this research was to investigate whether in female patients with uterine endometrial cancer or myoma in comparison to healthy women, the concentration of cadmium in blood affects the process of coagulation and fibrinolysis. Materials and Methods: The study group comprised 91 women: 35 healthy (A-control), 39 with uterine myoma (B) and 17 with endometrial cancer (C), in which blood cadmium concentrations (BCd), coagulation and selected fibrinolysis parameters in plasma were assayed. Results: In the women with myoma and especially in those with endometrial cancer disturbances in coagulation and fibrinolysis were detected when compared to the healthy women. In the group of women with endometrial cancer significant changes in prothrombin index, levels of fibrinogen, fibrin D-dimer and t-PA were observed. Whereas, in the patients with myoma significant changes in prothrombin time, index of vWillebrand Factor and fibrin D-dimer level were noted. Mean BCd concentrations in subsequent groups were as follows: B -0.91±0.81; C -0.78±0.45 μg Cd/l and did not differ significantly in comparison with the control group (0.86±0.35 μg Cd/l). However, in each study group smokers had approximately twice as high BCd as non-smokers. Studies also showed significant associations between BCd and fibrinogen level and thrombin time among the women with myoma and endometrial cancer, as well as in healthy women. Moreover, thrombin time significantly correlated with fibrinogen level in the women studied. Conclusions: In the patients with myoma and especially in these with endometrial cancer disturbances in coagulation and fibrinolysis parameters leading to hypercoagulability were detected. Exposure to cadmium can be one of the factors inducing these changes.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

The effect of cadmium on the coagulation and fibrinolytic system in women with uterine endometrial cancer and myoma

Nasiadek¹,

Kilanowicz²,

Daragó³

et al. 2013

International Journal of Occupational Medicine and Environmental Health

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“…Many variables regarding advanced disease were identified as significant risk factors for VTE before treatment Thromboembolism in endometrial carcinoma T Satoh et al in endometrial cancer, whereas our recent study revealed that various risk factors regarding advanced disease other than massive ascites were not significant risk factors for VTE before treatment in ovarian cancer. As for VTE after surgery or during treatment, a considerable number of previous reports have indicated advanced disease as a significant risk factor for VTE in gynaecological malignancies (Dubuc-Lissoir et al, 1999;Agnelli et al, 2006;Wang et al, 2006). Among non-endometrioid histologies, clear cell histology seems to represent the highest risk factor (clear cell histology, 4 out of 6 (66.7%); non-clear cell histology, 4 out of 15 (26.7%)).…”

Section: Discussionmentioning

confidence: 99%

Silent venous thromboembolism before treatment in endometrial cancer and the risk factors

et al. 2008

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Venous thromboembolism (VTE) often occurs after surgery and can even occur before surgery in patients with gynaecological malignancies. We investigated the incidence of VTE before treatment of endometrial cancer and associated risk factors. Plasma D-dimer (DD) levels before initial treatment were examined in 171 consecutive patients with endometrial cancer. Venous ultrasound imaging (VUI) of the lower extremities was performed in patients with DD X1.5 mg ml À1 , as the negative predictive value of DD for VTE is extremely high. For patients with deep vein thrombosis (DVT), pulmonary scintigraphy was performed to ascertain the presence of pulmonary thromboembolism (PTE). Risk factors for VTE were analysed using univariate and multivariate analyses for 171 patients. Of these, 37 patients (21.6%) showed DD X1.5 mg ml À1 , 17 (9.9%) displayed DVT by VUI and 8 (4.7%) showed PTE on pulmonary scintigraphy. All patients with VTE were asymptomatic. Univariate analysis for various risk factors revealed older age, non-endometrioid histology and several variables of advanced disease as significantly associated with VTE before treatment. Obesity, smoking and diabetes mellitus were not risk factors. Multivariate analysis confirmed extrauterine spread and non-endometrioid histology as independently and significantly associated with risk of VTE. These data suggest that silent or subclinical VTE occurs before treatment in at least around 10% of patients with endometrial cancer. Risk factors for VTE before treatment might not be identical to those after starting treatment.

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“…Our patient population included women with ovarian, uterine, and cervical malignancies; the majority of patients were treated for ovarian cancer, a patient group that is associated with a higher incidence of VTE than other gynecologic malignances 21. There were no findings of PE or DVT in follow-up, and there were few filter-related complications.…”

Section: Discussionmentioning

confidence: 99%

Three-year experience of prophylactic placement of inferior vena cava filters in women with gynecological cancer

Babu¹,

Khan²,

Coates³

2013

IJGM

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ObjectiveTo evaluate the outcomes of prophylactic placement of inferior vena cava (IVC) filters to prevent pulmonary embolism (PE) in women undergoing surgery and chemotherapy for gynecological cancer.Methods and materialsThirty-eight IVC filters were placed in 38 women between January 2008 and January 2010; 25 of these were placed in gynecological cancer patients for prevention of PE during surgery and the postoperative period. The patients’ electronic medical records, follow-up computed tomography scans, and outpatient follow-up notes were retrospectively reviewed for incidence of PE and adverse events.ResultsAfter 6 months of follow-up, no PE was observed and there was no mortality. Nine filters were retrieved uneventfully, and there were no clinical complications associated with any indwelling filter.ConclusionIVC filters are safe and beneficial towards preventing PE in women undergoing surgery and chemotherapy for gynecological cancer.

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Venous thromboembolism syndrome in gynecological cancer

Cited by 20 publications

References 130 publications

The effect of cadmium on the coagulation and fibrinolytic system in women with uterine endometrial cancer and myoma

The effect of cadmium on the coagulation and fibrinolytic system in women with uterine endometrial cancer and myoma

Silent venous thromboembolism before treatment in endometrial cancer and the risk factors

Three-year experience of prophylactic placement of inferior vena cava filters in women with gynecological cancer

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