Venous Thromboembolism Secondary to Penile Prosthesis

Shiraev, Timothy; Graham, Antony R.

doi:10.1016/j.avsg.2014.06.076

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…Some authors also report circumcision as a risk factor for PMD [9,24]. As well, there have been reports of compression of pelvic vasculature by inflatable penile prostheses, and it is plausible that the compression needed for stasis in PMD can occur in this setting as well [30].…”

Section: Pathogenesismentioning

confidence: 97%

Evaluation and Treatment of Penile Thrombophlebitis (Mondor’s Disease)

Manimala

Parker

2015

Curr Urol Rep

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Superficial penile thrombophlebitis or penile Mondor's disease (PMD) is an underreported condition that causes anxiety and embarrassment in affected men. Patients usually present with a smooth, cord-like induration on the dorsal penile shaft 1-7 days after prolonged or intensive sexual intercourse, but other presentations of disease and triggers for endothelial damage are possible. The condition is typically self-limited with expected spontaneous resolution within 4-8 weeks of initial presentation, and absolute diagnosis is usually not necessary with management including supportive care and pain control. However, when disease course is prolonged or there are concerning risk factors, it may be important to differentiate PMD from other conditions such as Peyronie's disease, hypercoagulability, blood stasis, genitourinary infection, and malignancy. History and physical are often sufficient to distinguish these conditions from PMD, but providers may employ ultrasound to assist with the diagnosis. If PMD does not spontaneously resolve, patients may be considered for thrombectomy, at which point histological analysis can confirm the diagnosis.

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Section: Pathogenesismentioning

confidence: 97%

Evaluation and Treatment of Penile Thrombophlebitis (Mondor’s Disease)

Manimala

Parker

2015

Curr Urol Rep

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“…Overall, surgical placement of venous compression devices is not utilized in modern clinical practice; one reason is their restriction to treating vascular ED, with little utility in patients with ED of metabolic, neurologic, or psychologic etiologies. Iatrogenic venous compression also holds theoretical concern of thromboembolic events, though this has not been reported in penile devices in the literature ( 18 , 19 ).…”

Section: Resultsmentioning

confidence: 99%

Addressing the need for preclinical study of penile prosthesis infection: a new animal model and narrative review

Shah,

Liu,

Machado

et al. 2024

Transl Androl Urol

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Background and Objective Erectile dysfunction (ED) is a common condition in men, and many patients refractory to conservative treatment may undergo penile prostheses (PPs) placement. The primary concern following PP implantation is device infection. Although antibiotic and hydrophilic coatings have reduced the incidence of inflatable PP (IPP) infections, there remains room for improvement. Optimization of PP outcomes requires a practical in vivo model to better understand mechanisms of infection and to test new infection control strategies. We aimed to describe a new rabbit model which contains a functional IPP and review previously reported animal PP models. Methods An IPP was placed into rabbit flanks and cycled for functionality testing. Rabbits were evaluated for signs of pain and distress over 14 days. Separately, narrative review methodology was utilized to search the PubMed and Scopus databases for all publications through March 21, 2023, which studied PP within an in vivo setting. Three independent reviewers ultimately selected 12 papers from 1992–2021 for inclusion. Key Content and Findings Several animal studies highlighted the initial functionality or feasibility of devices for ED before their introduction in the clinical setting. There are several subsequent studies aimed at optimizing the type of antibiotic use or coating material using segments of PP material in an in vivo setting. However, the literature lacks a contemporary animal model containing a functional IPP. Our novel rabbit model offers a safe, practical way to implant a functioning IPP and investigate new perioperative infection prevention and treatment strategies before trials in the clinical setting. Conclusions Animal models have played a key role in testing medical devices, including PPs, prior to their clinical introduction. Our review uncovered no modern animal studies involving placement of a functional PP. A new animal model can facilitate study of evolving microorganism profiles, novel methods to enhance antibiotic delivery, and proposed treatment options.

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