Venous thromboembolism risk score during hospitalization in pregnancy: results of 10694 prospective evaluations in a clinical trial

Barros, Venina Isabel Poço Viana Leme de; Igai, Ana Maria Kondo; Baptista, Fernanda Spadotto; Bortolotto, Maria Rita Lemos; Peres, Stela Verzinhasse; Francisco, Rossana Pulcineli Vieira

doi:10.1016/j.clinsp.2023.100230

Cited by 1 publication

(1 citation statement)

References 25 publications

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“…We acknowledge that the study could benefit from a multi-variable model but believe the main findings would not change significantly given that other studies have shown similar variables (ie, transfusion) are linked to thromboembolism. 26 , 27 This will not detract from the fact that the identified risk factors are significant; in fact, this may mean the true relationship may be stronger than that was identified in this study.…”

Section: Discussionmentioning

confidence: 72%

Venous Thromboembolism Risk Factors in Women With Obesity Who Undergo Cesarean Delivery

Fatokun,

Swartz,

Ebeid

et al. 2024

Clin Appl Thromb Hemost

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Venous thromboembolism (VTE) is a leading cause of maternal mortality. Obesity and cesarean delivery are established risk factors for pregnancy-related VTE. We identified additional risk factors among patients with obesity who underwent a cesarean delivery to identify those who need VTE prophylaxis. We conducted a secondary analysis of data from the Maternal-Fetal Medicine Units Network (MFMU) Cesarean Registry Database using a case-control design. Cases were identified as women with obesity having a pre-pregnancy body mass index of >30 kg/m2, who underwent cesarean delivery and subsequently developed deep venous thrombosis (DVT) or pulmonary embolism (PE). These women were compared to a control group of women with obesity who underwent cesarean delivery but did not develop DVT or PE. Analysis of risk factors associated with VTE was performed using Chi-Square test and Fisher's exact test. We identified 43 VTE cases and 172 controls in the MFMU database. Increased risk of VTE was noted in women with endometritis (OR of 4.58 [95% CI: 1.86-11.2, P = .0004]), receiving a blood transfusion (OR 17.07 [95% CI: 4.46-65.3, P = .0001]), having a coagulopathy (OR 27.73 [95% CI: 3.24-237.25, P = .0003]), and urinary tract infection (OR 2.39 [95% CI: 1.08-5.28, P = .03]). Important risk factors for VTE in women with obesity who undergo cesarean delivery include endometritis, intra- or post-operative transfusion, coagulopathy, and urinary tract infection. The presence of one or more of these factors may help guide provider decision-making regarding whether to administer thromboprophylaxis.

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Section: Discussionmentioning

confidence: 72%