Venous Thromboembolism: Review of Clinical Challenges, Biology, Assessment, Treatment, and Modeling

Watson, Connor; Saaid, Hicham; Vedula, Vijay; Cardenas, Jessica C.; Henke, Peter K.; Nicoud, Franck; Xu, Xiao Yun; Hunt, Beverley J.; Manning, Keefe B.

doi:10.1007/s10439-023-03390-z

Cited by 5 publications

(3 citation statements)

References 184 publications

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“…Using in vitro experiments and numerical simulation, the design of these filters has been characterized and optimized with a focus on maximizing thrombus capture efficiency, minimizing areas of low wall shear stress, and ensuring minimal disruption to blood flow (Singer, Wang & Diachin 2010; Feng, Li & Feng 2022). We recommend the recent review by Watson et al. (2024) for a discussion of modelling efforts in this domain to understand flow-mediated mechanisms driving deep vein thrombosis.…”

Section: Venous Flowmentioning

confidence: 99%

Cardiovascular fluid dynamics: a journey through our circulation

Menon,

Hu,

Marsden

2024

Flow

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This article presents a broad overview of the fluid mechanics of the human cardiovascular system. Beginning in the heart, we travel through the main features of our circulation to highlight important functions and diseases where fluid mechanics plays a central role. Of particular focus is the role of computational modelling in uncovering the dynamic flow phenomenon throughout our body, its association with cardiovascular disease mechanisms and progression and its importance in clinical treatment planning. We also emphasize the multiscale nature of the cardiovascular system, and associated challenges. The main aim of this review is to highlight progress and ongoing challenges in our understanding of cardiovascular haemodynamics, as well as the future outlook for translating the current state-of-the-art to widespread clinical application and improved patient outcomes.

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Section: Venous Flowmentioning

confidence: 99%

Cardiovascular fluid dynamics: a journey through our circulation

Menon,

Hu,

Marsden

2024

Flow

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“…It can be caused by disturbed blood flow behind a venous valve, poor blood circulation to extremities, or at high altitude. 15 Similarly, local inflammation caused by the presence of activated mast cells or platelets results in endothelial activation and the important Weibel-Palade body release of VWF and P-selectin. This recruits platelets and neutrophils (Figure 1), providing them with activating intracellular signaling.…”

Section: Endothelial Activation and Platelet-neutrophil Interactionsmentioning

confidence: 99%

Reflections on Targeting Neutrophil Extracellular Traps in Deep Vein Thrombosis

Martinod,

Wagner

2024

ATVB

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“…The dissemination of tumor-derived microvesicles promotes hypercoagulability and increased PLT activation ( 24 ). Intrinsic heparin plays an important role in balancing the blood flow patency and thrombosis ( 25 ). In cancer therapy, preoperative irradiation produces lesions triggering both bleeding and thrombosis, and most chemotherapeutic protocols affect PLT synthesis ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

Thromboelastogram and coagulation function index: relevance for female breast cancer

Peng,

Zhu,

Ren

2024

Front. Oncol.

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IntroductionScreening and postoperative intervention of breast tumors are critical for the effective diagnosis and treatment of disease development, and reliable diagnostic/screening methods become a key link. ObjectiveThromboelastogram (TEG), routine platelet (PLT) count, and the coagulation function indicators in patients with different breast diseases were determined and analyzed to explore their predictive value in secondary bleeding disorders.MethodsA total of 131 patients with breast diseases, admitted to Jiangsu University Affiliated Hospital from January 2019 to December 2022, were selected as the research subjects. The detection items were analyzed using the receiver operating curve (ROC) after grouping for secondary bleeding disorders of patients with breast cancer.ResultsThe reaction (R) and the coagulation (K) times were lower in the malignant breast disease group, while the coagulation angle (α), maximum amplitude (MA), coagulation index (CI), fibrinogen (FIB), and D-dimer (D-D) were higher than those in the benign breast disease group. The t-tests proved that the MA and FIB values were statistically significant (p < 0.05) in the benign and malignant breast disease groups. The R and K in patients with breast diseases were positively correlated with the activated partial thromboplastin time (aPTT) and D-D, but were negatively correlated with PLT. The α angle was negatively correlated with aPTT and D-D, but was positively correlated with PLT. The MA for PLT function was positively correlated with FIB and PLT. CI was negatively correlated with aPTT, thrombin time (TT), and D-D, but was positively correlated with PLT. ROC curve analysis showed that the CI and α angle had a significant predictive value, whereas the correlation of the other indicators was relatively low.ConclusionCoagulation tests showed significant differences in patients with breast cancer, differing from those with benign breast diseases. TEG combined with conventional coagulation indicators is potentially valuable for the prediction of secondary bleeding disorders in patients with breast cancer.

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Venous Thromboembolism: Review of Clinical Challenges, Biology, Assessment, Treatment, and Modeling

Cited by 5 publications

References 184 publications

Cardiovascular fluid dynamics: a journey through our circulation

Cardiovascular fluid dynamics: a journey through our circulation

Reflections on Targeting Neutrophil Extracellular Traps in Deep Vein Thrombosis

Thromboelastogram and coagulation function index: relevance for female breast cancer

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