Venous thromboembolism in transgender women

Venous thromboembolism in women

“…Oral administration induces the hepatic first-pass effect with increased pro-thrombotic factors, whereas non-oral routes and transdermal administration in particular do not appear to induce increased VTE 7 .…”

“…The objectives of gender affirmation in transgender women are to suppress male characteristics and induce female characteristics to the extent possible. Gender affirmation can encompass hormone therapy (HT) and affirmation surgery 7 .…”

“…Provision of physician-guided gender affirmation HT has shown improved quality of life, and it reduces the disorders observed in this population, including VTE 7 .…”

“…Several different studies have demonstrated an increased risk of VTE in transgender women who are on HT, which is related to the type and dosage of the hormones employed and, primarily, to the route of administration 1 . This can be a determinant factor in the choice of HT, making transdermal administration the preferred route for transgender women with a personal or family history of VTE or those who have thrombophilia 7 .…”

“…This can be a determinant factor in the choice of HT, making transdermal administration the preferred route for transgender women with a personal or family history of VTE or those who have thrombophilia 7 .…”