Venous Thromboembolism in Patients with Renal Insufficiency: Findings from the RIETE Registry

Monréal, Manuel; Falgá, C.; Valle, Reina; Barba, Raquel; Bosco, Juan; Beato, José Luís; Maestre, Ana

doi:10.1016/j.amjmed.2006.04.028

Cited by 130 publications

(101 citation statements)

References 22 publications

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“…Furthermore, we examined PE only, whereas they measured any VTE. Our finding of higher mortality in patients with CKD and ESRD suffering PE is consistent with previous reports (44). We also report higher frequency of severe PE for both the CKD and ESRD populations compared with persons with normal kidney function.…”

Section: Discussionsupporting

confidence: 93%

Pulmonary Embolism in Patients with CKD and ESRD

Kumar

Sakhuja

Taneja

et al. 2012

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives CKD and ESRD are growing burdens. It is unclear whether these conditions affect pulmonary embolism (PE) risk, given that they affect both procoagulant and anticoagulant factors. This study examined the frequency and associated outcomes of PE in CKD and ESRD.Design, setting, participants, & measurements The Healthcare Cost and Utilization Project's Nationwide Inpatient Sample was used to estimate the frequency and outcomes of PE in adults with CKD and ESRD. Hospitalizations for the principal diagnosis of PE and presence of CKD or ESRD were identified using International Classification of Diseases, Ninth Revision codes. Data from the annual US Census and US Renal Data System reports were used to calculate the number of adults with CKD, ESRD, and normal kidney function (NKF) as well as the annual incidence of PE in each group. Logistic regression modeling was used to compare in-hospital mortality among persons admitted for PE who had ESRD or CKD to those without these conditions. ResultsThe annual frequency of PE was 527 per 100,000, 204 per 100,000, and 66 per 100,000 persons with ESRD, CKD, and NKF, respectively. In-hospital mortality was higher for persons with ESRD and CKD (P,0.001) compared with persons with NKF. Median length of stay was longer by 1 day in CKD and 2 days in ESRD than among those with NKF.Conclusions Persons with CKD and ESRD are more likely to have PE than persons with NKF. Once they have PE, they are more likely to die in the hospital.

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Section: Discussionsupporting

confidence: 93%

Pulmonary Embolism in Patients with CKD and ESRD

Kumar

Sakhuja

Taneja

et al. 2012

Clinical Journal of the American Society of Nephrology

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“…The impact of renal insufficiency on the risk for PE after hip and knee arthroplasty is less well studied. A recent study in the general population suggested that the rate of fatal PE is increased with progressive decrease in creatinine clearance [17]. Further, renal failure was identified as a risk factor for VTE in the general postsurgical patient population, including after orthopaedic surgery [7].…”

Section: Discussionmentioning

confidence: 99%

Risk factors for pulmonary embolism after hip and knee arthroplasty: a population-based study

Memtsoudis

Besculides

Gaber³

et al. 2008

International Orthopaedics (SICOT)

103

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“…The Registro Informatizado de la Enfermedad Tromboembó lica (RIETE) initiative is an ongoing, international (Spain, France, Italy, Israel and Argentina), multicentre, prospective registry of consecutive patients presenting with symptomatic acute venous thromboembolism (VTE) confirmed by objective tests [12][13][14][15][16]. The aim of the present study was to compare the predictive value of the three clinical parameters (shock index, SBP ,100 mmHg and SBP ,90 mmHg) on 30-day mortality in all patients with acute PE.…”

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confidence: 99%

Haemodynamically unstable pulmonary embolism in the RIETE Registry: systolic blood pressure or shock index?

Otero

Trujillo‐Santos²,

Cayuela³

et al. 2007

European Respiratory Journal

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Patients with acute pulmonary embolism (PE) presenting with haemodynamic instability have the worst prognosis. However, what is understood by haemodynamic instability has not been clearly defined.The Registro Informatizado de la Enfermedad Tromboembólica (RIETE) is an ongoing registry of consecutive patients with symptomatic, objectively confirmed, acute deep vein thrombosis or PE. The present authors compared the predictive value of a systolic blood pressure (SBP) value of ,100 mmHg and ,90 mmHg and the shock index (cardiac frequency divided by SBP) on 30-day mortality in consecutive patients with PE.As of May 2006, 6,599 patients with PE were enrolled in the study. Of these, 417 (6.3%) died within 30 days: 153 of the initial PE, 29 of recurrent PE and 235 due to other causes. Of the 417 individuals who died, 127 (30%) had a positive shock index, 60 (14%) had SBP ,100 mmHg and 33 (7.9%) had SBP ,90 mmHg. On multivariate analysis any of the three parameters were independently associated with an increased mortality. The shock index had a higher sensitivity (30.5 versus 14.4 and 7.9% for SBP ,100 mmHg and ,90 mmHg, respectively) but lower specificity (86.3 versus 93.0 and 96.6).All three measures of haemodynamic instability are independent predictors of 30-day mortality. However, while the shock index had the highest sensitivity, a systolic blood pressure value ,90 mmHg had the highest specificity.

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Venous Thromboembolism in Patients with Renal Insufficiency: Findings from the RIETE Registry

Cited by 130 publications

References 22 publications

Pulmonary Embolism in Patients with CKD and ESRD

Pulmonary Embolism in Patients with CKD and ESRD

Risk factors for pulmonary embolism after hip and knee arthroplasty: a population-based study

Haemodynamically unstable pulmonary embolism in the RIETE Registry: systolic blood pressure or shock index?

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