Venous Thromboembolism in Patients Hospitalized with Nephrotic Syndrome

Kayali, Fadi; Najjar, Reiad; Aswad, Firas Al; Matta, Fadi; Stein, Paul D.

doi:10.1016/j.amjmed.2007.08.042

Cited by 105 publications

(86 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The nephrotic syndrome, a common presentation of AL, is associated with hypercoagulability and may contribute to the risk of venous thromboembolism (VTE) in this population. [10][11][12][13][14][15] Other potential contributors to thromboembolic risk include monoclonal gammopathy and plasma cell dyscrasia 16 as well as AL treatments, specifically immunomodulatory agents (IMiDs) [17][18][19][20][21][22][23] and those requiring central venous catheters. A means of risk stratification of VTE in this population is needed to guide prophylaxis and treatment strategies.…”

Section: Introductionmentioning

confidence: 99%

Risk factors for venous thromboembolism in immunoglobulin light chain amyloidosis

et al. 2015

View full text Add to dashboard Cite

P atients with immunoglobulin light chain amyloidosis are at risk for both thrombotic and bleeding complications. While the hemostatic defects have been extensively studied, less is known about thrombotic complications in this disease. This retrospective study examined the frequency of venous thromboembolism in 929 patients with immunoglobulin light chain amyloidosis presenting to a single referral center, correlated risk of venous thromboembolism with clinical and laboratory factors, and examined complications of anticoagulation in this population. Sixty-five patients (7%) were documented as having at least one venous thromboembolic event. Eighty percent of these patients had events within one year prior to or following diagnosis. Lower serum albumin was associated with increased risk of VTE, with a hazard ratio of 4.30 (CI 1.60-11.55; P=0.0038) for serum albumin less than 3 g/dL compared to serum albumin greater than 4 g/dL. Severe bleeding complications were observed in 5 out of 57 patients with venous thromboembolism undergoing treatment with anticoagulation. Prospective investigation should be undertaken to better risk stratify these patients and to determine the optimal strategies for prophylaxis against and management of venous thromboembolism. Risk factors for venous thromboembolism in immunoglobulin light chain amyloidosis

show abstract

Section: Introductionmentioning

confidence: 99%

Risk factors for venous thromboembolism in immunoglobulin light chain amyloidosis

et al. 2015

View full text Add to dashboard Cite

show abstract

“…This hypercoagulable state is likely caused by multiple factors, including platelet activation and aggregation, hyperfibrinogenemia, loss of antithrombin, hypoplasminogenemia and increased levels of plasminogen activator inhibitor [7]. The prevalence of pulmonary embolism in nephrotic patients has been greatly different among studies and can be asymptomatic or even lethal [6]. Although the MTHFR 677C->T polymorphism increases the homocysteine levels, the association between clinical suspicion of chronic thromboembolic pulmonary hypertension was confirmed using lung perfusion scintigraphy and the right hearth catheterization (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

“…An association between hypercoagulability and nephrotic syndrome (NS), which is characterized by heavy proteinuria, hypoalbuminemia, hyperlipidemia and edema, has been established many years ago [6,7]. This hypercoagulable state is likely caused by multiple factors, including platelet activation and aggregation, hyperfibrinogenemia, loss of antithrombin, hypoplasminogenemia and increased levels of plasminogen activator inhibitor [7].…”

Section: Discussionmentioning

confidence: 99%

Hereditary hyperhomocysteinemia associated with nephrotic syndrome complicated by artery thrombosis and chronic thromboembolic pulmonary hypertension: A case report

Ruggeri¹,

Bello²,

Nucera³

et al. 2017

Monaldi Arch Chest Dis

View full text Add to dashboard Cite

We present here the case of a 30-year-old man with a long term history of nephrotic syndrome (NS) who developed an episode of acute left main pulmonary artery thrombosis complicated by a lung abscess. During the hospital admission was also identified a concomitant hyperhomocysteinemia. After an atypical resection of the left upper pulmonary lobe and the starting of long term anticoagulation the patient was discharged but did not attend the planned follow up visits until one year later when he was seen again for severe dyspnea and exercise intolerance. At this time chronic thromboembolic pulmonary hypertension (CTEPH) was diagnosed by lung perfusion scintigraphy and right heart catheterization. He initially refused the surgical treatment but, after six months, for the presence of worsening dyspnea was referred for bilateral pulmonary endarterectomy followed by a cardio-thoracic rehabilitation program. After a follow-up of seven years the patient is alive and in stable conditions. NS and hyperhomocysteinemia are both known risk factors for pulmonary embolism (PE), but their association with CTEPH is extremely rare. We discuss here the possible mechanisms linking these conditions. CTEPH must be suspected in any patient with NS, with or without hyperhomocysteinemia, and unexplained dyspnea.

show abstract

“…Sever nephrotic syndrome may increase the risk of thromboembolism [2]. FSGS is classified according to the aetiology into primary (idiopathic) and secondary.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2017

UNOAJ

View full text Add to dashboard Cite

Patients with primary focal segmental glomerulosclerosis (FSGS) have a high risk of disease recurrence post renal transplantation; this is usually characterised by significant proteinuria and associated with poor graft survival. FSGS recurrence is a challenging medical condition, not only because there is no recognised predictor of FSGS recurrence in the allograft, but also because there are no available international guidelines for treatment of this condition which add more mystery to the dilemma created by this vague syndrome. Our work aimed to draw the attention to the latest available evidence addressing recurrence of FSGS in the renal allograft, in an attempt to improve our understanding of this condition. This also helps to guide the future studies towards the promising approaches in diagnosis and management of this condition. Ultimately this will result in better graft survival and lower the demands for another renal transplant giving the universal shortage of transplantable organs.

show abstract

Venous Thromboembolism in Patients Hospitalized with Nephrotic Syndrome

Cited by 105 publications

References 19 publications

Risk factors for venous thromboembolism in immunoglobulin light chain amyloidosis

Risk factors for venous thromboembolism in immunoglobulin light chain amyloidosis

Hereditary hyperhomocysteinemia associated with nephrotic syndrome complicated by artery thrombosis and chronic thromboembolic pulmonary hypertension: A case report

Untitled

Contact Info

Product

Resources

About