Venous Thromboembolism in Brain Tumor Patients

Jeraq, Mohammed; Coté, David J.; Smith, Timothy R.

doi:10.1007/5584_2016_117

Cited by 13 publications

(3 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In patients with temporary immobilization or loss of motor ability, lower limbs should be elevated, leg massage should be performed, pharmacological prevention or mechanical thrombus prevention should be performed using progressive pressure socks, intermittent pneumatic compression (IPC), etc. ( 44 , 45 ). At the same time, the frequency of lower limb venous ultrasound screening should be increased to discover lower extremity DVT earlier ( 46 ).…”

Section: Discussionmentioning

confidence: 99%

Prognostic nomogram for predicting lower extremity deep venous thrombosis in ruptured intracranial aneurysm patients who underwent endovascular treatment

Zhang,

Zhu,

Zhang

et al. 2023

Front. Neurol.

View full text Add to dashboard Cite

BackgroundLower extremity deep vein thrombosis (DVT) is one of the major postoperative complications in patients with ruptured intracranial aneurysms (RIA) who underwent endovascular treatment (EVT). However, patient-specific predictive models are still lacking. This study aimed to construct and validate a nomogram model for estimating the risk of lower extremity DVT for RIA patients who underwent EVT.MethodsThis cohort study enrolled 471 RIA patients who received EVT in our institution between 1 January 2020 to 4 February 2022. Perioperative information on participants is collected to develop and validate a nomogram for predicting lower extremity DVT in RIA patients after EVT. Predictive accuracy, discriminatory capability, and clinical effectiveness were evaluated by concordance index (C-index), calibration curves, and decision curve analysis.ResultMultivariate logistic regression analysis showed that age, albumin, D-dimer, GCS score, middle cerebral artery aneurysm, and delayed cerebral ischemia were independent predictors for lower extremity DVT. The nomogram for assessing individual risk of lower extremity DVT indicated good predictive accuracy in the primary cohort (c-index, 0.92) and the validation cohort (c-index, 0.85), with a wide threshold probability range (4–82%) and superior net benefit.ConclusionThe present study provided a reliable and convenient nomogram model developed with six optimal predictors to assess postoperative lower extremity DVT in RIA patients, which may benefit to strengthen the awareness of lower extremity DVT control and supply appropriate resources to forecast patients at high risk of RIA-related lower extremity DVT.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic nomogram for predicting lower extremity deep venous thrombosis in ruptured intracranial aneurysm patients who underwent endovascular treatment

Zhang,

Zhu,

Zhang

et al. 2023

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…Cancer has been long recognized as an independent and significant risk factor for venous thromboembolism (VTE) [ 1 ]. Patients with primary brain tumors are a particularly vulnerable subgroup, likely due to an underlying hypercoagulability associated with brain tumors in addition to risks associated with surgery or paresis [ 2 ]. The presence of IDH1 mutations has been recently described as a risk factor [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Management of Thromboembolic Disease in Patients with Primary and Metastatic Brain Tumors

Woods

Lesser

2023

Curr. Treat. Options in Oncol.

View full text Add to dashboard Cite

Opinion statementPatients with primary brain tumors are at a substantially elevated risk of venous thromboembolism (VTE) compared to other disease states or other forms of malignancy. Deep venous thrombosis (DVT) and pulmonary embolism (PE), often complicate the care of patients with primary brain tumors, and treatment may pose specific unique risks and considerations for management. This paper critically reviews the relevant literature and the most common treatment options in addition to a discussion regarding the relative risk considerations for neurooncology patients facing thromboembolic disease.

show abstract

“…Cancer progression is generally correlated with perturbations in the hemostatic system [1] and patients with different cancers have up to seven-fold increased risk of developing venous thromboembolism (VTE) [2,3]. Patients with brain cancer, particularly those with high-grade glioma (grade 3-4) have a high risk of developing VTE [4,5]. Glioblastoma multiforme (GBM) is often associated with increased risk of developing coagulopathies and systemic thromboembolic disease [6], causing increased risk for morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

Assessment of genetic and non-genetic risk factors for venous thromboembolism in glioblastoma – The predictive significance of B blood group

Heenkenda

Malmström

Łysiak

et al. 2019

Thrombosis Research

View full text Add to dashboard Cite

Introduction: Venous thromboembolism (VTE) is a common problem among patients with glioblastoma multiforme (GBM) and with some other cancers. Here, we evaluated genetic and non-genetic potential risk factors for VTE among GBM patients. Materials and methods:A cohort of 139 patients treated with concomitant radiotherapy and temozolomide were included in the study. Next generation sequencing and genotyping approaches were applied to assess genetic risk factors in the haemostatic system. Clinical data including surgery, reoperation as well as blood group and patient information such as age and gender were available from patient records. Logistic regression analysis was performed to asses VTE risk.Results: In the study 47 patients (34%) were diagnosed for VTE during the course of their disease. When genetic and non-genetic potential risk factors were evaluated, only B blood group was found to be significantly associated with VTE incidence (odds ratio [OR]=6.91; confidence interval [CI]=2.19-24.14; P=0.001). In contrast, A and O blood groups did not correlate with VTE risk. Frontal lobe tumor location also seemed to slightly increase VTE risk compared to other brain sites (OR=3.14; CI=1.1-10.7) although the significance level was at borderline (P=0.05). Current study identified B blood group as the component in non-O blood groups that is responsible for increased VTE risk. Conclusion:In conclusion, these results suggest for the first time that B blood group is predictive for VTE incidence among patients with glioblastoma, information that may be potentially valuable when selecting GBM patients who are at risk for VTE for anticoagulant prophylaxis.

show abstract

Venous Thromboembolism in Brain Tumor Patients

Cited by 13 publications

References 95 publications

Prognostic nomogram for predicting lower extremity deep venous thrombosis in ruptured intracranial aneurysm patients who underwent endovascular treatment

Prognostic nomogram for predicting lower extremity deep venous thrombosis in ruptured intracranial aneurysm patients who underwent endovascular treatment

Management of Thromboembolic Disease in Patients with Primary and Metastatic Brain Tumors

Assessment of genetic and non-genetic risk factors for venous thromboembolism in glioblastoma – The predictive significance of B blood group

Contact Info

Product

Resources

About