Venous Thromboembolism and Risk of Cancer in Patients with Diverticular Disease: A Danish Population-Based Cohort Study

Thomsen, Louise T.; Troelsen, Frederikke Schønfeldt; Nagy, Dávid; Skajaa, Nils; Farkas, Dóra Körmendiné; Erichsen, Rune

doi:10.2147/clep.s314350

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…As the incidence of diverticular disease increases [ 45 , 46 ] emergent colectomies are becoming more frequent [ 6 , 47 ]. Emergency colorectal surgery and diverticular disease are known independent risk factors for VTE [ 9 , 48 ]. Despite this rising prevalence, post-colectomy VTE rates for diverticular disease in particular have not been previously explored.…”

Section: Clinical Relevancementioning

confidence: 99%

Venous thromboembolism following colectomy for diverticular disease: an English population-based cohort study

Yapa

Humes

Crooks

et al. 2023

Langenbecks Arch Surg

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Aim This study reports venous thromboembolism (VTE) rates following colectomy for diverticular disease to explore the magnitude of postoperative VTE risk in this population and identify high risk subgroups of interest. Method English national cohort study of colectomy patients between 2000 and 2019 using linked primary (Clinical Practice Research Datalink) and secondary (Hospital Episode Statistics) care data. Stratified by admission type, absolute incidence rates (IR) per 1000 person-years and adjusted incidence rate ratios (aIRR) were calculated for 30- and 90-day post-colectomy VTE. Results Of 24,394 patients who underwent colectomy for diverticular disease, over half (57.39%) were emergency procedures with the highest VTE rate seen in patients ≥70-years-old (IR 142.27 per 1000 person-years, 95%CI 118.32–171.08) at 30 days post colectomy. Emergency resections (IR 135.18 per 1000 person-years, 95%CI 115.72–157.91) had double the risk (aIRR 2.07, 95%CI 1.47–2.90) of developing a VTE at 30 days following colectomy compared to elective resections (IR 51.14 per 1000 person-years, 95%CI 38.30–68.27). Minimally invasive surgery (MIS) was shown to be associated with a 64% reduction in VTE risk (aIRR 0.36 95%CI 0.20–0.65) compared to open colectomies at 30 days post-op. At 90 days following emergency resections, VTE risks remained raised compared to elective colectomies. Conclusion Following emergency colectomy for diverticular disease, the VTE risk is approximately double compared to elective resections at 30 days while MIS was found to be associated with a reduced risk of VTE. This suggests advancements in postoperative VTE prevention in diverticular disease patients should focus on those undergoing emergency colectomies.

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Section: Clinical Relevancementioning

confidence: 99%

Venous thromboembolism following colectomy for diverticular disease: an English population-based cohort study

Yapa

Humes

Crooks

et al. 2023

Langenbecks Arch Surg

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“…Patients with both uncomplicated diverticulitis and perforated complicated diverticulitis have a 40% increased risk of developing venous thrombosis. 1 While there are reports of diverticulitis associated with gonadal vein thrombosis, 2 there is no literature to date on postoperative development of gonadal vein thrombus extending into the renal vein after sigmoid colectomy. Our case report details a patient with no significant risk factors who developed left gonadal vein thrombosis extending into the left renal vein after colectomy.…”

mentioning

confidence: 99%

Simultaneous Ovarian and Renal Vein Thrombosis as a Rare Cause of Postoperative Pain After Sigmoid Colectomy

Chandran

Hani

Hain

2023

The American Surgeon™

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Post operative pain is often the cause of many ED visits. When patients are discharged and return with postoperative abdominal pain, common etiologies include incisional pain, neuropathic pain, musculoskeletal pain from immobility, ileus, and more sinister causes including adhesive bowel obstruction, abscess formation, and anastomotic leak. We present a 62 year-old female without any hereditary thrombophilia or other prothrombotic factors who presented to the ED after a sigmoid colectomy and diverting ileostomy for perforated diverticulitis and subsequent ileostomy reversal with abdominal pain. CT discovered a left ovarian vein thrombus extending into the left renal vein. With a myriad of diagnoses, it is important to have a low threshold for imaging to rule out serious pathology and also diagnose any unusual causes that can be treated promptly to prevent organ damage and subsequent complications.

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Risk of Cancer in Patients With Diverticular Disease: A Population-Based Cohort Study

Troelsen,

Farkas,

Erichsen

et al. 2024

Clinical Gastroenterology and Hepatology

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Venous Thromboembolism and Risk of Cancer in Patients with Diverticular Disease: A Danish Population-Based Cohort Study

Cited by 5 publications

References 30 publications

Venous thromboembolism following colectomy for diverticular disease: an English population-based cohort study

Venous thromboembolism following colectomy for diverticular disease: an English population-based cohort study

Simultaneous Ovarian and Renal Vein Thrombosis as a Rare Cause of Postoperative Pain After Sigmoid Colectomy

Risk of Cancer in Patients With Diverticular Disease: A Population-Based Cohort Study

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