Venous thromboembolism after induced abortion: a population-based, propensity-score-matched cohort study in Canada

Liu, Ning; Vigod, Simone N.; Farrugia, Michele; Urquía, Marcelo L.; Ray, Joel G.

doi:10.1016/s2352-3026(18)30069-3

Cited by 12 publications

(7 citation statements)

References 27 publications

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“…20,21 Recent large cohort study proved that the rate of VTE within 42 days of an induced abortion was 3.0 per 10,000 women (hazard ratio, 0.16, 95% CI, 0•12-0•22) when compared with women in the live birth cohort, whose VTE rate was 18.5 per 10,000 women. 22 The risk might be due to pathologies common to RPL and VTE. The frequency of VTE was found to be 7.5 per 10,000 pregnancies in the present Japanese population registered between 2011 and 2014.…”

Section: Discussionmentioning

confidence: 99%

Endometriosis and Recurrent Pregnancy Loss as New Risk Factors for Venous Thromboembolism during Pregnancy and Post-Partum: The JECS Birth Cohort

et al. 2019

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Background Since venous thromboembolism (VTE) is one of the causes of maternal mortality, several guidelines recommend prophylaxis using low molecular weight heparin for women in high-risk groups. The number of large population-based studies examining predictors for VTE has been limited, and there has been no study based on a Japanese population. Objective Our objective was to examine VTE risk factor during the pregnancy and post-partum period. Materials and Methods A nationwide birth cohort study known as the ‘Japan Environment and Children's Study (JECS)’ was conducted by the Ministry of the Environment. The subjects consisted of 103,070 pregnancies recruited by the JECS between January 2011 and March 2014. Pregnant women completed the questionnaires during the first and second/third trimester. Their medical records were transcribed by physicians or research coordinators at registration, just after delivery and at 1 month after delivery. Results The frequency of VTE was 7.5 per 10,000 pregnancies (77 of 103,070) during the pregnancy and post-partum period. After the adjustment of multiple covariates for each factor, endometriosis and recurrent pregnancy loss (RPL) were identified as novel independent risk factors for VTE. Adjusted odds ratios were as follows: 2.70 (95% confidence interval, 1.21–6.00) for endometriosis and 6.13 (2.48–15.16) for RPL. Threatened abortion, threatened pre-term birth, pre-term birth and caesarean section were ascertained to be risk factors for VTE. Conclusion Careful attention should be given to novel predictors, such as endometriosis and a history of RPL, to prevent VTE during the pregnancy and post-partum period.

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Section: Discussionmentioning

confidence: 99%

Endometriosis and Recurrent Pregnancy Loss as New Risk Factors for Venous Thromboembolism during Pregnancy and Post-Partum: The JECS Birth Cohort

et al. 2019

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“…As far as molecular diagnosis is concerned, and despite clear guidelines ( 15 ), in Romania, testing for inherited thrombophilia remains deficient in numerous departments of different specialties in the national health system, and is not commonly suggested in clinical practice. Although in certain branches such as obstetrics and haematology, molecular testing for thrombophilia is frequently used ( 16 ); in others, such as otorhinolaryngology it is completely absent.…”

Section: Discussionmentioning

confidence: 99%

Lateral sinus thrombosis in a young patient with sudden neurosensorial hearing loss and genetic thrombophilia: A case report

et al. 2022

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Sensorineural hearing loss (SSHL) with a sudden onset is frequently encountered as a medical emergency in the ear, nose and throat (ENT) practice. The exact pathophysiology of the disease remains unknown, with the most likely etiologies being viral infection, inflammation, drug toxicity, trauma, or autoimmune response. Even though thrombophilia and cerebrovascular complications may lead, among others, to sudden neurosensorial hearing loss, its diagnosis is most often made following the onset of thrombotic complications. A case of a young female patient with unknown congenital hypercoagulation status complicated with lateral sinus thrombosis and unilateral drug-induced reversible hearing loss is presented. Molecular testing confirmed the diagnosis of genetic thrombophilia, due to the homozygous V Leiden, homozygous MTHFR A1298C, and heterozygous MTHFR C677T mutations. Although hereditary thrombophilia is a well-known topic in medical practice, current guidelines require continuous improvement, especially among patients treated in departments where this pathology is more difficult to recognize and manage.

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“…A large cohort study by Liu et al 24 was completed in Canada to try to establish the risk of VTE after TOP. A propensity score was used, which matched primigravid women who underwent STOP with those who had a livebirth (1:1) (postpartum group) and nulliparous women who were not pregnant and did not conceive within 1 year (5:1).…”

Section: Review Of Existing Researchmentioning

confidence: 99%

The risk of venous thromboembolism in early pregnancy loss: Review of the literature and current guidelines and the need for guidance – Communication from the SSC on Women’s Health Issues for thrombosis and haemostasis

Collins

Memtsa

Kirk

et al. 2022

Journal of Thrombosis and Haemostasis

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Background: Thromboembolic disease is one of the major causes of mortality and morbidity in pregnancy and the puerperium, with 1 death per 100 000 births attributed to venous thromboembolism (VTE). Factors associated with development of thrombosis are all present in pregnancy, with some of these changes seen from conception.Objective: Given how common early pregnancy loss is, the aim of this review is to evaluate the uncertainty surrounding the risk of VTE following early pregnancy loss and termination of pregnancy.Methods: A structured literature search was conducted to identify existing evidence as well as international pregnancy-specific guidelines regarding assessment and prevention of VTE risk in pregnant women. This review was reviewed, critiqued, and approved by all members of the International Society on Thrombosis and Haemostasis subcommittee for Women's Health Issues in Thrombosis and Haemostasis.Results: Four published original research studies, one clinical comment paper, and six guidelines were reviewed. Despite clear evidence of the increased risk of VTE in pregnancy, there is a lack of guidance regarding evaluation and management after early pregnancy loss. Conclusion:International collaborative research to determine the risk of VTE and its prevention in women undergoing surgical termination of pregnancy or following surgical management of early pregnancy loss is urgently needed. Pregnancy-specific risk assessment taking into account preexisting risk factors is advocated. Education of health care professionals involved in early pregnancy care and guidance on management, albeit based on limited existing evidence, are necessary to highlight the need for individualized care.

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Venous thromboembolism after induced abortion: a population-based, propensity-score-matched cohort study in Canada

Cited by 12 publications

References 27 publications

Endometriosis and Recurrent Pregnancy Loss as New Risk Factors for Venous Thromboembolism during Pregnancy and Post-Partum: The JECS Birth Cohort

Endometriosis and Recurrent Pregnancy Loss as New Risk Factors for Venous Thromboembolism during Pregnancy and Post-Partum: The JECS Birth Cohort

Lateral sinus thrombosis in a young patient with sudden neurosensorial hearing loss and genetic thrombophilia: A case report

The risk of venous thromboembolism in early pregnancy loss: Review of the literature and current guidelines and the need for guidance – Communication from the SSC on Women’s Health Issues for thrombosis and haemostasis

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