Venous Thromboembolism

Beckman, Michele G.; Hooper, W. Craig; Critchley, Sara E.; Ortel, Thomas L.

doi:10.1016/j.amepre.2009.12.017

Cited by 875 publications

(366 citation statements)

References 42 publications

Supporting

Mentioning

330

Contrasting

Unclassified

Order By: Relevance

“…VTE is characterized by high mortality rates and a high rate of recurrence among survivors,2 and it has been identified as an important health concern for women in particular 3. Furthermore, studying the link between PTSD symptoms and VTE specifically in a sample of younger and middle‐aged women has particular relevance for understanding VTE risk in women.…”

Section: Discussionmentioning

confidence: 99%

“…Within the past decade, the National Institutes of Health, Center for Disease Control, and Surgeon General have made concerted efforts directed at VTE prevention 2. Given that VTE is associated with long‐term complications and high mortality rates, it is critical to diagnose cases early and accurately.…”

Section: Discussionmentioning

confidence: 99%

“…Venous thromboembolism (VTE), encompassing deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most common cause of cardiovascular death and the leading preventable cause of hospital‐based death 1, 2. Although VTE has been identified as a major public health concern for men and women,2 certain factors make it particularly relevant to women's health 3.…”

Section: Introductionmentioning

confidence: 99%

“…Although VTE has been identified as a major public health concern for men and women,2 certain factors make it particularly relevant to women's health 3. Female‐specific risk factors for VTE related to reproductive hormone exposure (eg, due to contraceptive therapy, pregnancy, and hormone therapy [HT]) have been documented,3 and VTE is a leading cause of mortality among pregnant and recently postpartum women in the United States 2. Additionally, VTE incidence rates are higher in women of childbearing age than in men of the same age,4, 5 likely reflecting VTE induced by pregnancy and/or oral contraceptive use during childbearing years.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, VTE incidence rates are higher in women of childbearing age than in men of the same age,4, 5 likely reflecting VTE induced by pregnancy and/or oral contraceptive use during childbearing years. Given the disease burden and highly recurrent nature of VTE—a largely preventable condition—greater insight into factors that may increase risk or promote prevention, particularly in women, is a significant public health priority 2, 3. Furthermore, given that 26% to 47% of VTE cases are classified as occurring in the absence of major established risk factors (eg, cancer, surgery, and pregnancy),6 better understanding of VTE risk has important clinical relevance.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Associations of Trauma Exposure and Posttraumatic Stress Symptoms With Venous Thromboembolism Over 22 Years in Women

Sumner

Kubzansky

Kabrhel

et al. 2016

JAHA

View full text Add to dashboard Cite

BackgroundTrauma exposure and posttraumatic stress disorder (PTSD) have been linked to myocardial infarction and stroke in women, with biological and behavioral mechanisms implicated in underlying risk. The third most common cardiovascular illness, venous thromboembolism (VTE), is a specific health risk for women. Given previous associations with other cardiovascular diseases, we hypothesized that high levels of trauma and PTSD symptoms would be associated with higher risk of incident VTE in younger and middle‐aged women.Methods and ResultsWe used proportional hazards models to estimate hazard ratios (HRs) and 95% CIs for new‐onset VTE (960 events) over 22 years in 49 296 women in the Nurses’ Health Study II. Compared to no trauma exposure, both trauma exposure and PTSD symptoms were significantly associated with increased risk of developing VTE, adjusting for demographics, family history, and childhood adiposity. Women with the most PTSD symptoms exhibited the greatest risk elevation: trauma/6 to 7 symptoms: HR=2.42 (95% CI, 1.83–3.20); trauma/4 to 5 symptoms: HR=2.00 (95% CI, 1.55–2.59); trauma/1 to 3 symptoms: HR=1.44 (95% CI, 1.12–1.84); trauma/no symptoms: HR=1.72 (95% CI, 1.43–2.08). Results were similar, although attenuated, when adjusting for VTE‐relevant medications, medical conditions, and health behaviors.ConclusionsWomen with the highest PTSD symptom levels had nearly a 2‐fold increased risk of VTE compared to women without trauma exposure in fully adjusted models. Trauma exposure alone was also associated with elevated VTE risk. Trauma and PTSD symptoms may be associated with a hypercoagulable state. Treatment providers should be aware that women with trauma exposure and PTSD symptoms may be vulnerable to VTE.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%