Venous Thromboembolic Disease

Streiff, Michael B.; Bockenstedt, Paula; Cataland, Spero R.; Chesney, Carolyn M.; Eby, Charles S.; Fanikos, John; Fogarty, Patrick F.; Gao, Shuwei; García-Aguilar, Julio; Goldhaber, Samuel Z.; Hassoun, Hani; Hendrie, Paul C.; Holmstrom, Bjorn; Jones, Kimberly; Kuderer, Nicole M.; Lee, Jason T.; Millenson, Michael; Neff, Anne T.; Ortel, Thomas L.; Smith, Judy L.; Yee, Gary C.; Zakarija, Anaadriana

doi:10.6004/jnccn.2011.0062

Cited by 111 publications

(62 citation statements)

References 306 publications

(557 reference statements)

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“…This model and the other large studies have undoubtedly influenced the introduction of consideration of some cancer sites into some guidelines, such as those of the NCCN. 6 Our study is vital for improvement of guidelines and other risk stratification models. It provides a more extensive set of precise estimates of risk from a population independent of previous studies.…”

Section: Discussionmentioning

confidence: 99%

“…4 Current United Kingdom (UK) guidelines, published by the National Institute for Health and Clinical Excellence (NICE) 5 indicate use of thromboprophylaxis in cancer patients with on-going cancer or cancer treatment, but only routinely to those with reduced mobility, and not ambulatory patients. United States (US) guidelines from the National Clinical Cancer Network (NCCN) 6 are similar in their treatment of inpatients, but have a more detailed assessment of VTE risk factors and suggest that some outpatient chemotherapy patients could also benefit from prophylaxis. The recent American College of Chest Physicians guidelines have also recently changed to suggest thromboprophylaxis in outpatients at high risk of VTE.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Incidence of venous thromboembolism in patients with cancer – A cohort study using linked United Kingdom databases

Walker

Card

West

et al. 2013

European Journal of Cancer

407

359

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Incidence of venous thromboembolism in patients with cancer – A cohort study using linked United Kingdom databases

Walker

Card

West

et al. 2013

European Journal of Cancer

407

359

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“…21,22 The most recent guidelines from the National Comprehensive Cancer Network call for the assessment of VTE risk in ambulatory patients with cancer and randomized controlled trials of thromboprophylaxis in those at high risk of VTE and low risk of bleeding. 23 Paradoxically, patients with cancer who were prescribed thromboprophylaxis after hospital discharge were more likely to develop VTE in the outpatient setting. We speculate that some may have already developed asymptomatic VTE before or during hospitalization.…”

Section: Discussionmentioning

confidence: 99%

Venous Thromboembolism in Hospitalized Patients With Active Cancer

Piazza

Rao

Nguyen

et al. 2013

Clin Appl Thromb Hemost

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Venous thromboembolism (VTE) is a common complication of cancer and chemotherapy. We evaluated the baseline clinical characteristics, thromboprophylaxis patterns, frequency and timing of VTE, and clinical outcomes in 1000 adult hospitalized patients with active cancer. Overall, symptomatic VTE occurred in 5.4% of hospitalized patients with cancer. The VTE occurred in 2.3% of patients with cancer during hospitalization and in 3.4% between hospital discharge and day 90. Few (13.9%) hospitalized patients with cancer received extended duration pharmacological prophylaxis after hospital discharge. Cancer was the most frequent known cause of death in both the groups. In conclusion, VTE was common in hospitalized patients with cancer, especially after discharge. Inhospital death and death between discharge and day 90 were frequent in hospitalized patients with cancer who developed VTE.

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“…1–3 In a population-based case-control study of approximately 3000 patients with VTE, investigators found a sevenfold higher risk of VTE among patients with cancer than among those without cancer. 4 Other studies have indicated that 20% to 29% of all VTEs occur in patients with cancer.…”

mentioning

confidence: 99%

Thromboprophylaxis Guidelines in Cancer with a Primary Focus on Ambulatory Patients Receiving Chemotherapy: A Review from the Southern Network on Adverse Reactions (SONAR)

Maxwell

Bennett

2012

Semin Thromb Hemost

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Patients with cancer are at increased risk for venous thromboembolism (VTE). Factors related to cancer type, site, stage, duration, and extent of disease contribute to the oncology patient’s risk of VTE. Patient-specific factors such as history of prior VTE and comorbidity are also contributory. The role of treatment-related factors, including chemotherapy regimen, has been a focus of recent investigation because most cases of VTE in the oncology setting occur in ambulatory patients. Thus, an emerging area of clinical research is primary VTE prophylaxis in the ambulatory cancer setting. Clinical guidelines currently recommend primary thromboprophylaxis in cancer patients who are undergoing surgery, who are hospitalized, and who are in a specific subset of high-risk ambulatory cancer patients. Validated risk stratification tools are essential for identification of patients who are at high risk of thrombosis. Emerging data from recently published clinical trials, as well as ongoing studies, are likely to advance our understanding of the potential utility of antithrombotic agents for primary prophylaxis in ambulatory patients with cancer and may influence future clinical guideline recommendations.

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Venous Thromboembolic Disease

Cited by 111 publications

References 306 publications

Incidence of venous thromboembolism in patients with cancer – A cohort study using linked United Kingdom databases

Incidence of venous thromboembolism in patients with cancer – A cohort study using linked United Kingdom databases

Venous Thromboembolism in Hospitalized Patients With Active Cancer

Thromboprophylaxis Guidelines in Cancer with a Primary Focus on Ambulatory Patients Receiving Chemotherapy: A Review from the Southern Network on Adverse Reactions (SONAR)

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