Venous involvement in islet cell tumors of the pancreas

Bok, EJ; Cho, KJ; Williams, D. Bradley G.; Brady, TM; Weiss, C A; Forrest, ME

doi:10.2214/ajr.142.2.319

Cited by 40 publications

(18 citation statements)

References 19 publications

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“…Unfortunately, a proportion may present late with tumors that encase or invade adjacent major blood vessels 8-10. A number of studies have shown vascular invasion in both patients with pancreatic adenocarcinomas and advanced PETs is associated with decreased survival 2, 4, 11-15.…”

Section: Introductionmentioning

confidence: 99%

Pancreatic Endocrine Tumors With Major Vascular Abutment, Involvement, or Encasement and Indication for Resection

Norton

Harris²,

Chen³

et al. 2011

Arch Surg

106

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Section: Introductionmentioning

confidence: 99%

Pancreatic Endocrine Tumors With Major Vascular Abutment, Involvement, or Encasement and Indication for Resection

Norton

Harris²,

Chen³

et al. 2011

Arch Surg

106

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“…20 However, even if involvement or infi ltration of the portal, superior mesenteric, or splenic veins is obvious at surgery, it does not contraindicate resection. 6,21 The absence of malignant cells in the surgical margin has a major infl uence on postoperative survival.…”

Section: Discussionmentioning

confidence: 99%

Curative resection of a huge malignant pancreatic endocrine tumor by pancreatoduodenectomy with portal and superior mesenteric vein resection and reconstruction using the right ovarian vein: Report of a case

et al. 2011

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Nonfunctioning pancreatic endocrine tumors (PETs) are rare and generally asymptomatic. A 68-year-old woman who had refused treatment for a pancreatic mass, revealed by ultrasonography to be 55 mm in diameter, was referred to us again 29 months later with jaundice. Investigations showed an 82-mm tumor in the head of pancreas, exposed from the papilla of Vater to the duodenal lumen. After biliary decompression and drainage, we performed pancreatoduodenectomy with resection of the portal vein and superior mesenteric vein, followed by reconstruction using a cylindrically customized autologous graft harvested from the right ovarian vein. The tumor was resected curatively. Microscopically, it consisted of trabecular and ribbon-like arrangement of neoplastic cells. Immunohistochemical staining was positive for chromogranin A and synaptophysin and negative for insulin, gastrin, glucagons, somatostatin, and pancreatic peptide. Although metastasis was detected in a lymph node along the superior mesenteric vein with perineural invasion, the portal and superior mesenteric veins had not been invaded. The diagnosis was well-differentiated nonfunctioning PET. The patient had an uneventful postoperative course, and there has been no evidence of recurrence in 12 months.

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“…8 Whereas venous involvement is a common feature of pancreatic ductal adenocarcinomas, it is a rare feature of nonfunctioning islet cell carcinomas, although cases of venous occlusion, venous encasement, and intraportal tumor growth have been reported. 9 Venous involvement associated with islet cell tumors can be recognized on CT or magnetic resonance images. 10 Surgical resection is the treatment of choice for pancreatic islet cell tumors, because it can improve the quality of life, prolong survival, and reduce the incidence of metastases, with an acceptable rate of complications and practically zero mortality.…”

Section: Discussionmentioning

confidence: 99%

Portal Vein Resection for a Portal Vein Thrombus Caused by Nonfunctioning Islet Cell Carcinoma: Report of a Case

et al. 2004

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We report a case of nonfunctioning islet cell carcinoma of the pancreas causing a tumor thrombus in the portal vein. The patient was a 60-year-old woman whose presenting symptoms were abdominal pain, vomiting, and weight loss. We performed a subtotal pancreatectomy and splenectomy combined with partial resection of the portal vein. Histopathological studies confirmed the diagnosis of nonfunctioning islet cell carcinoma of the pancreas with a tumor thrombus in the portal vein. The patient's postoperative course was uneventful and she is doing well 25 months after the operation.

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Venous involvement in islet cell tumors of the pancreas

Cited by 40 publications

References 19 publications

Pancreatic Endocrine Tumors With Major Vascular Abutment, Involvement, or Encasement and Indication for Resection

Pancreatic Endocrine Tumors With Major Vascular Abutment, Involvement, or Encasement and Indication for Resection

Curative resection of a huge malignant pancreatic endocrine tumor by pancreatoduodenectomy with portal and superior mesenteric vein resection and reconstruction using the right ovarian vein: Report of a case

Portal Vein Resection for a Portal Vein Thrombus Caused by Nonfunctioning Islet Cell Carcinoma: Report of a Case

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