“…12 However, multiple studies, 2,31 including a recent meta-analysis of 1006 patients, demonstrated no difference in the overall rate of complications (including hemothorax, pneumothorax, infection, catheter thrombosis, stenosis, kinking or extravasation, migration of the catheter or dislodging of the port reservoir, hematoma, seroma, nerve palsy, thoracic duct injury, and death) or, in particular, in the rates of infection with either technique. It is worth noting that, when the analysis was limited to a subclavian site for the PT group, there was a higher rate of catheter-related complications (thrombosis, fibrin sheath, stenosis, kinking, extravasation, migration of the catheter, or dislodgement of the reservoir) compared with ST. 32 The decision of which technique to choose ultimately may depend on the presence of risk factors that make the patient prone to particular complications associated with a technique. In patients with severe dehydration, neutropenia, prior radiation to the area, and other factors that may increase the primary failure rate, preference should be for the use of PT with ultrasound guidance via the internal jugular or cephalic route (over the subclavian route) to minimize failure and pneumothorax incidence.…”