Venous Blood-Based Biomarkers in the China Health and Retirement Longitudinal Study: Rationale, Design, and Results From the 2015 Wave

Chen, Xinxin; Crimmins, Eileen M.; Hu, Peifeng; Kim, Jung Ki; Meng, Qinqin; Strauss, John; Wang, Yafeng; Zeng, Junxia; Zhang, Yuan S; Zhao, Yaohui

doi:10.1093/aje/kwz170

Cited by 116 publications

(101 citation statements)

References 9 publications

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“…CHARLS collected and assayed venous blood samples in 2011 and 2015 waves. Analysis of blood samples encompassed 2 stages: (1) a complete blood count analysis was performed at local county health center after collection; and (2) the samples were all then transferred to the study headquarters where they were assayed [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

The change and correlates of healthy ageing among Chinese older adults: findings from the China health and retirement longitudinal study

Wang

Zhang

et al. 2021

BMC Geriatr

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Background This study tentatively constructs a composite measure of Chinese Healthy Ageing Index (CHAI) among older adults aged 60+ and investigates change of CHAI during 2011–2015 and its association with sociodemographic characteristics. Methods Data collected from 8182 old adults aged 60+ in the 2011 and 2015 China Health and Retirement Longitudinal Study (CHARLS, a nationally representative sample) were used. Six medical measures of blood pressure, peak expiratory flow, cognitive status score, fasting glucose, kidney function and C-reactive function were used to construct CHAI (range 0–12, 0–2 = healthiest, 7–12 = unhealthiest). Ordinary least squares, logistic and random effects models examined social and spatial determinants of CHAI score and the prevalence of the ideal CHAI. Unconditional quantile regression tested heterogeneous impacts of sociodemographic determinants of CHAI score. Results Mean CHAI score declined from 5.7 to 5.2, and the proportion of the ideal CHAI (CHAI score = 0–2) increased from 5.6 to 9.4% during 2011–2015, indicating an improvement in healthy ageing over time. During 2011–2015, the highest rates of the ideal CHAI were in Southeast and East of China. Older adults, male, living in the Center and West, smoking, obesity/overweight and having chronic diseases were positively associated with total CHAI score and negatively with a higher prevalence of the ideal CHAI. Being married, having high education and regular social activities were associated with a higher rate of the ideal CHAI. The positive predictors for total CHAI were stronger in those with worse CHAI status. Conclusions In China healthy ageing has improved during 2011–2015, but substantial geographical and sociodemographic heterogeneities exist in the improvements, suggesting health equality remains a challenge in China. Future policies and interventions should especially focus on men, those in Central and West China, and combat health problems like obesity, chronic diseases and unhealthy behaviors.

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Section: Methodsmentioning

confidence: 99%

The change and correlates of healthy ageing among Chinese older adults: findings from the China health and retirement longitudinal study

Wang

Zhang

et al. 2021

BMC Geriatr

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“…All blood samples were shipped to Beijing and stored at -70°C. High-sensitivity C-reactive protein (CRP), total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, fasting glucose, creatinine, and uric acid were tested [ 19 , 20 ]. Creatinine levels were measured using a rate-blanked and compensated Jaffe creatinine method.…”

Section: Methodsmentioning

confidence: 99%

Anemia and Kidney Function Decline among the Middle-Aged and Elderly in China: A Population-Based National Longitudinal Study

Yang

Meng

Wang

et al. 2020

BioMed Research International

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Chronic kidney disease (CKD) is a public health burden, and anemia is common among patients with CKD. However, less is known regarding the longitudinal association between anemia and deterioration of kidney function among the general population. The China Health and Retirement Longitudinal Study is a nationally representative survey for households with members aged ≥ 45 years. Participants without creatinine and demographic data in 2011 and 2015 were excluded. Anemia was defined according to definitions of the World Health Organization. Rapid decline in kidney function was defined as a ≥16.9% (quartile 3) decline in estimated glomerular filtration rate (eGFR), calculated using the CKD-EPI equation during 2011-2015. Multivariate logistic regression and restricted cubic splines were used to explore their relationship. Altogether, 7210 eligible participants were included in the analysis, with a mean age of 58.6 ± 8.8 years. Rapid decline in kidney function occurred among 1802 (25.0%) participants. Those with kidney function decline were more likely to be older, male, and have anemia, lower eGFRs, hypertension, and cardiovascular disease ( P < 0.05 ). Anemia, or hemoglobin, was independently associated with rapid decline in kidney function after adjusting for potential confounding factors ( OR = 1.64 , 95% CI, 1.32-2.04; OR = 0.90 , 95% CI, 0.87-0.94, respectively). Restricted cubic splines showed a nonlinear relationship between hemoglobin and rapid decline in kidney function, especially for men with anemia ( P < 0.05 ). In conclusion, anemia is an independent risk factor for progression of kidney function among the middle-aged and elderly population. Attentive management and intervention strategies targeting anemia could be effective to reduce the risk of kidney failure and improve the prognosis of the general population.

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“…Further details about the process of the blood sample collection, transportation and storage have been published elsewhere. 17 In the 2015-2016 wave of CHARLS, a total of 21 095 adults were interviewed and 20 284 participants were asked to consent to a venous blood draw: 13 013 (64.2%) donated whole blood, 17 of which 6743 participants were 60 years or older. The analytical sample consisted of 6706 adults who (1) were 60 years or older, (2) had complete data on creatinine and cystatin C (needed to estimate kidney function), and (3) had cross-sectional blood Kidney function CKD is defined as abnormalities of kidney structure or function, present for 3 months, with implications for health; GFR is generally accepted as the best index of kidney function, and reduced kidney function is defined as a GFR less than 60 mL/min per 1.73 m², according to Kidney Disease Improving Global Outcomes guidelines.…”

Section: Cohort and Participantsmentioning

confidence: 99%

Prevalence and health correlates of reduced kidney function among community-dwelling Chinese older adults: the China Health and Retirement Longitudinal Study

Jin

Zhou

2020

BMJ Open

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ObjectivesWe aimed to understand the prevalence of reduced kidney function in China by sociodemographics and geographical region, and to examine health correlates of reduced kidney function.DesignCross-sectional study.Setting and participantsParticipants were 6706 adults ≥60 years from the 2015–2016 wave of the China Health and Retirement Longitudinal Study.Outcome measuresReduced kidney function was defined as an estimated glomerular filtration rate of less than 60 mL/min per 1.73 m². The estimated glomerular filtration rate was calculated with the creatinine–cystatin C equation developed by the Chronic Kidney Disease Epidemiology Collaboration in 2012. The associations between reduced kidney function and potential risk factors were analysed using multivariable regression models.ResultsThe prevalence of reduced kidney function was 10.3% (95% CI: 9.3% to 11.2%), corresponding to approximately 20 million older adults. Multivariable analysis showed that older adults with hypertension (β=−3.61, 95% CI: −4.42 to 2.79), cardiac disease (β=−1.90, 95% CI: −2.93 to 0.86), who had a stroke (β=−3.75, 95% CI: −6.35 to 1.15), kidney disease (β=−3.88, 95% CI: −5.62 to 2.13), slow gait speed (β=−2.23, 95% CI: −3.27 to 1.20), and living in the South (β=−4.38, 95% CI: −5.95 to 2.80) and South Central (β=−1.85, 95% CI: −3.15 to 0.56) were more significantly likely to have reduced kidney function.ConclusionsKidney function screening should be performed, especially in patients with hypertension, cardiac disease and who had a stroke. More efforts should be paid to improve the kidney function of older adults living in the South and South Central parts of China.

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Venous Blood-Based Biomarkers in the China Health and Retirement Longitudinal Study: Rationale, Design, and Results From the 2015 Wave

Cited by 116 publications

References 9 publications

The change and correlates of healthy ageing among Chinese older adults: findings from the China health and retirement longitudinal study

The change and correlates of healthy ageing among Chinese older adults: findings from the China health and retirement longitudinal study

Anemia and Kidney Function Decline among the Middle-Aged and Elderly in China: A Population-Based National Longitudinal Study

Prevalence and health correlates of reduced kidney function among community-dwelling Chinese older adults: the China Health and Retirement Longitudinal Study

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