Venomous Insect Hypersensitivity

Boord, Mona J.

doi:10.1002/9781118738818.ch29

Cited by 9 publications

(34 citation statements)

References 11 publications

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“…This case report demonstrates and supports previous claims that utilizing VIT with human albumin can sensitize canine patients to this foreign protein 3) . This is the first case report to the authors' knowledge that demonstrates reactivity to human albumin in VIT in the canine.…”

Section: Discussionsupporting

confidence: 89%

Anaphylaxis in a canine patient sensitized to human albumin while on honeybee immunotherapy

2019

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Venom immunotherapy (VIT) provides an opportunity to reduce life-threatening reactions to venomous insect stings. VIT requires stabilization with human albumin. This report describes a Labrador Retriever that developed anaphylaxis during VIT induction. Intradermal testing (IDT) identified a human albumin hypersensitivity. Four years later, re-testing revealed a persistent hypersensitization to human albumin. To identify if VIT is a risk factor for human albumin sensitivity, IDT was performed in 4 honeybee allergic dogs being treated with VIT, with 6 healthy and 6 atopic dogs as controls. One other dog reacted to human albumin at the testing concentrations. This dog was being treated with VIT but had no clinical manifestations. VIT containing human albumin may lead to sensitization of this protein and anaphylaxis.

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Section: Discussionsupporting

confidence: 89%

Anaphylaxis in a canine patient sensitized to human albumin while on honeybee immunotherapy

2019

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“…mastocytosis, asthma). 10,23,24 In dogs, the triggers of urticaria and/ or anaphylaxis that are supported by original studies or case reports are vaccines, 25 anaesthetics, 26,27 food, 28,29 venoms, [30][31][32] drugs, 1,17 glucocorticoids, 33 transfusions, 34 plants 35 and radiocontrast media. 36 Some rare causes such as heat, exercise, sunlight, dermatographism, estrous, intestinal parasites, allergen-specific immunotherapy and intradermal testing are only anecdotally reported in veterinary textbooks.…”

Section: Introductionmentioning

confidence: 99%

Triggers, risk factors and clinico‐pathological features of urticaria in dogs – a prospective observational study of 24 cases

Rostaher¹,

Hofer‐Inteeworn

Kümmerle‐Fraune

et al. 2017

Advances in Veterinary Dermatology

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Background -Urticaria and anaphylaxis are frequently encountered in veterinary practice, but little is known about the causes and relative frequencies of these reactions.Hypothesis/Objectives -This study was designed to improve current knowledge on the triggers, risk factors and clinico-pathological features of urticaria.Animals -Twenty four dogs with signs of urticaria with or without anaphylaxis.Methods -The study included dogs with cutaneous immediate-type hypersensitivity reactions. The cases were grouped by clinical severity into either an urticaria or an anaphylaxis group. All treatments and diagnostic tests (haematology, biochemical profile, allergy investigation) were recorded. A causality algorithm for urticaria and anaphylaxis (ALUA) was designed to determine the probability of the identified triggers and cofactors. Disease incidence, breed, age and gender predispositions were evaluated statistically.Results -Sixteen of 24 urticaria cases were associated with anaphylaxis whilst 8 of 24 were confined to the skin. The annual hospital incidence was 0.12%. Females seemed to be over-represented (2.4:1) and most of the dog breeds were pure breed (22 of 24), with Rhodesian ridgeback, boxer, beagle, Jack Russell terrier, French bulldog and Vizslas over-represented. In addition to skin lesions, the most frequently and severely affected organ systems were the gastrointestinal and cardiovascular systems. The predominant blood abnormalities were elevated lipase and alanine aminotransferase values. Insects, food and drugs were the most commonly identified triggers.Conclusions -To the best of our knowledge, this is the first study describing the trigger factors and clinicopathological features of dogs with urticaria in veterinary medicine. Insects, food and drugs were the most frequently detected triggers.

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“…This is very likely due to the fact that these same dogs were stung by insects, which most commonly causes deep tissue oedema. 30 Surprisingly, although angioedema was often encountered on the head region, none of our cases encountered laryngeal or other respiratory involvement as reported elsewere. 56 It is clear that the severity of skin lesions did not affect the patient's outcomes, but these typical lesions (wheals, angioedema and flushing) seem to be an excellent marker for anaphylaxis, as shown in human medicine.…”

Section: Discussionmentioning

confidence: 39%

“…The low frequency of skin involvement from previous studies could be partly explained by the lack of precise dermatological observations in addition to the different clinical criteria for our study Although not statistically significant, there was a tendency for dogs with anaphylaxis to experience more frequent angioedema without wheals. This is very likely due to the fact that these same dogs were stung by insects, which most commonly causes deep tissue oedema . Surprisingly, although angioedema was often encountered on the head region, none of our cases encountered laryngeal or other respiratory involvement as reported elsewere .…”

Section: Discussionmentioning

confidence: 54%

“…mastocytosis, asthma) . In dogs, the triggers of urticaria and/or anaphylaxis that are supported by original studies or case reports are vaccines, anaesthetics, food, venoms, drugs, glucocorticoids, transfusions, plants and radiocontrast media . Some rare causes such as heat, exercise, sunlight, dermatographism, estrous, intestinal parasites, allergen‐specific immunotherapy and intradermal testing are only anecdotally reported in veterinary textbooks .…”

Section: Introductionmentioning

confidence: 99%

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Triggers, risk factors and clinico‐pathological features of urticaria in dogs – a prospective observational study of 24 cases

Rostaher

Hofer‐Inteeworn

Kümmerle‐Fraune

et al. 2016

Veterinary Dermatology

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Background-Urticaria and anaphylaxis are frequently encountered in veterinary practice, but little is known about the causes and relative frequencies of these reactions. Hypothesis/Objectives-This study was designed to improve current knowledge on the triggers, risk factors and clinico-pathological features of urticaria. Animals-Twenty four dogs with signs of urticaria with or without anaphylaxis. Methods-The study included dogs with cutaneous immediate-type hypersensitivity reactions. The cases were grouped by clinical severity into either an urticaria or an anaphylaxis group. All treatments and diagnostic tests (haematology, biochemical profile, allergy investigation) were recorded. A causality algorithm for urticaria and anaphylaxis (ALUA) was designed to determine the probability of the identified triggers and cofactors. Disease incidence, breed, age and gender predispositions were evaluated statistically. Results-Sixteen of 24 urticaria cases were associated with anaphylaxis whilst 8 of 24 were confined to the skin. The annual hospital incidence was 0.12%. Females seemed to be over-represented (2.4:1) and most of the dog breeds were pure breed (22 of 24), with Rhodesian ridgeback, boxer, beagle, Jack Russell terrier, French bulldog and Vizslas over-represented. In addition to skin lesions, the most frequently and severely affected organ systems were the gastrointestinal and cardiovascular systems. The predominant blood abnormalities were elevated lipase and alanine aminotransferase values. Insects, food and drugs were the most commonly identified triggers. Conclusions-To the best of our knowledge, this is the first study describing the trigger factors and clinico-pathological features of dogs with urticaria in veterinary medicine. Insects, food and drugs were the most frequently detected triggers.

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Venomous Insect Hypersensitivity

Cited by 9 publications

References 11 publications

Anaphylaxis in a canine patient sensitized to human albumin while on honeybee immunotherapy

Anaphylaxis in a canine patient sensitized to human albumin while on honeybee immunotherapy

Triggers, risk factors and clinico‐pathological features of urticaria in dogs – a prospective observational study of 24 cases

Triggers, risk factors and clinico‐pathological features of urticaria in dogs – a prospective observational study of 24 cases

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