2018
DOI: 10.1038/s41598-018-25955-y
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Venom proteomics and antivenom neutralization for the Chinese eastern Russell’s viper, Daboia siamensis from Guangxi and Taiwan

Abstract: The eastern Russell’s viper (Daboia siamensis) causes primarily hemotoxic envenomation. Applying shotgun proteomic approach, the present study unveiled the protein complexity and geographical variation of eastern D. siamensis venoms originated from Guangxi and Taiwan. The snake venoms from the two geographical locales shared comparable expression of major proteins notwithstanding variability in their toxin proteoforms. More than 90% of total venom proteins belong to the toxin families of Kunitz-type serine pro… Show more

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Cited by 63 publications
(60 citation statements)
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References 80 publications
(105 reference statements)
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“…The avidity ELISA was more discriminatory, with the strength of antibody-venom protein binding greatest for both antivenoms against the Thai D. siamensis venom (Figure 3). These results are in line with a previous study, which showed that the Thai DSAV antivenom exhibits immunoreactivity to D. siamensis venoms from Taiwan and Guanxi, South China, but to a lesser extent than the binding observed with Chinese monovalent antivenom [17].…”
Section: Discussionsupporting
confidence: 93%
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“…The avidity ELISA was more discriminatory, with the strength of antibody-venom protein binding greatest for both antivenoms against the Thai D. siamensis venom (Figure 3). These results are in line with a previous study, which showed that the Thai DSAV antivenom exhibits immunoreactivity to D. siamensis venoms from Taiwan and Guanxi, South China, but to a lesser extent than the binding observed with Chinese monovalent antivenom [17].…”
Section: Discussionsupporting
confidence: 93%
“…However, the treatment of systemic envenoming caused by D. siamensis has long been problematic in many Asian countries, due to challenges related to the access of antivenom and the dosing regimen used to effect cure. For example, in southern parts of mainland China, where envenoming by D. siamensis poses a substantial health problem, access to monovalent antivenoms is very limited, which has resulted in the use of non-specific or species-inappropriate antivenoms, leading to reports of treatment failures and mortality [17]. Herein, we examined the effectiveness of the Thai monovalent D. siamensis (DSAV) and Hemato Polyvalent (HPAV) antivenoms against three different geographical variants of D. siamensis using in vitro biochemical and immunological assays.…”
Section: Discussionmentioning
confidence: 99%
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“…The recent venomic study of Eastern Russell's viper from Taiwan and China revealed geographical venom variation that supports the clinical observation of envenoming effects [17,18]. In Southeast Asia, the proteomics of D. siamensis venom from Myanmar was previously reported [19]; however, an indepth venom proteome that details the protein subtypes and expression level for D. siamensis originating from Southeast Asia remains to be elucidated.…”
Section: Introductionmentioning
confidence: 64%