Venom Proteins from Parasitoid Wasps and  Their Biological Functions

Moreau, Sébastien; Asgari, Sassan

doi:10.3390/toxins7072385

Cited by 187 publications

(202 citation statements)

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“…Large scale combined “omics” studies have recently increased knowledge of the nature and diversity of the venom content of parasitoid wasps34. Yet, very few studies were designed to evaluate how far closely-related parasitoid species differ in venom composition.…”

Section: Discussionmentioning

confidence: 99%

“…movements, feeding). These components are often a complex mixture of ovarian and venom proteins34, but they also include virus-like particles (VLPs)5 or wasp-specific polydnaviruses (PDVs)6.…”

mentioning

confidence: 99%

“…Broad studies reporting transcriptomic and/or proteomic analyses have recently improved our knowledge of venom composition in different parasitoid families, evidencing its high complexity and diversity34. Indeed, although some venom proteins – e.g.…”

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confidence: 99%

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Comparative venomics of Psyttalia lounsburyi and P. concolor, two olive fruit fly parasitoids: a hypothetical role for a GH1 β-glucosidase

Mathe‐Hubert

Colinet

Deleury

et al. 2016

Sci Rep

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Venom composition of parasitoid wasps attracts increasing interest – notably molecules ensuring parasitism success on arthropod pests – but its variation within and among taxa is not yet understood. We have identified here the main venom proteins of two braconid wasps, Psyttalia lounsburyi (two strains from South Africa and Kenya) and P. concolor, olive fruit fly parasitoids that differ in host range. Among the shared abundant proteins, we found a GH1 β-glucosidase and a family of leucine-rich repeat (LRR) proteins. Olive is extremely rich in glycoside compounds that are hydrolyzed by β-glucosidases into defensive toxic products in response to phytophagous insect attacks. Assuming that Psyttalia host larvae sequester ingested glycosides, the injected venom GH1 β-glucosidase could induce the release of toxic compounds, thus participating in parasitism success by weakening the host. Venom LRR proteins are similar to truncated Toll-like receptors and may possibly scavenge the host immunity. The abundance of one of these LRR proteins in the venom of only one of the two P. lounsburyi strains evidences intraspecific variation in venom composition. Altogether, venom intra- and inter-specific variation in Psyttalia spp. were much lower than previously reported in the Leptopilina genus (Figitidae), suggesting it might depend upon the parasitoid taxa.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Comparative venomics of Psyttalia lounsburyi and P. concolor, two olive fruit fly parasitoids: a hypothetical role for a GH1 β-glucosidase

Mathe‐Hubert

Colinet

Deleury

et al. 2016

Sci Rep

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“…For example, the wasp larvae appear to produce a chitinase during emergence. Chitinases are a component of some wasp venoms (Moreau and Asgari, 2015). A chitinase could help the wasps dissolve the chitin of the host's exoskeleton, something each wasp must do in order to emerge from the host.…”

Section: Discussionmentioning

confidence: 99%

The parasitic wasp Cotesia congregata uses multiple mechanisms to control host (Manduca sexta) behaviour

Adamo

Kovalko

Turnbull

et al. 2016

Journal of Experimental Biology

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Some parasites alter the behaviour of their hosts. The larvae of the parasitic wasp Cotesia congregata develop within the body of the caterpillar Manduca sexta. During the initial phase of wasp development, the host's behaviour remains unchanged. However, once the wasps begin to scrape their way out of the caterpillar, the caterpillar host stops feeding and moving spontaneously. We found that the caterpillar also temporarily lost sensation around the exit hole created by each emerging wasp. However, the caterpillars regained responsiveness to nociception in those areas within 1 day. The temporary reduction in skin sensitivity is probably important for wasp survival because it prevents the caterpillar from attacking the emerging wasp larvae with a defensive strike. We also found that expression of plasmatocyte spreading peptide (PSP) and spätzle genes increased in the fat body of the host during wasp emergence. This result supports the hypothesis that the exiting wasps induce a cytokine storm in their host. Injections of PSP suppressed feeding, suggesting that an augmented immune response may play a role in the suppression of host feeding. Injection of wasp larvae culture media into non-parasitized caterpillars reduced feeding, suggesting that substances secreted by the wasp larvae may help alter host behaviour.

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“…Moreau and Asgari [35] present the latest research on constituents from parasitoid wasp venom with an emphasis on their biological function, applications, and new approaches used in venom studies.…”

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confidence: 99%

An Introduction to the Toxins Special Issue on “Bee and Wasp Venoms: Biological Characteristics and Therapeutic Application”

Pak

2016

Toxins

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Venom Proteins from Parasitoid Wasps and Their Biological Functions

Cited by 187 publications

References 152 publications

Comparative venomics of Psyttalia lounsburyi and P. concolor, two olive fruit fly parasitoids: a hypothetical role for a GH1 β-glucosidase

Comparative venomics of Psyttalia lounsburyi and P. concolor, two olive fruit fly parasitoids: a hypothetical role for a GH1 β-glucosidase

The parasitic wasp Cotesia congregata uses multiple mechanisms to control host (Manduca sexta) behaviour

An Introduction to the Toxins Special Issue on “Bee and Wasp Venoms: Biological Characteristics and Therapeutic Application”

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