Venom Peptides and Toxins - A Prospective Spearhead in Cancer Treatment

Wong, Janet Pik Ching; Li, Bin; Kwok, Hang Fai

doi:10.2174/1386207320666170621130425

Cited by 3 publications

(2 citation statements)

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“…Therefore, Venom based peptides have a wide range of application in modern biology from diagnostic to the treatment of the disease [ 10 ]. For example, Chlorotoxin analog drug BLZ-100 tagged with a fluorescence dye is able to lights up only cancer cells in brain tumor so that it can be precisely excised from the brain [ 11 ]. BLZ-100 is also known as “Tumor paint” is currently in phase 1b clinical study.…”

Section: Future Prospectsmentioning

confidence: 99%

Venom-based peptide therapy: insights into anti-cancer mechanism

Mahadevappa

Kwok

2017

Oncotarget

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The 5-year relative survival rate of all types of cancer has increased significantly over the past three decades partly due to the targeted therapy. However, still there are many targeted therapy drugs could play a role only in a portion of cancer patients with specific molecular alternation. It is necessary to continue to develop new biological agents which could be used alone and/or in combination with current FDA approved drugs to treat complex cancer diseases. Venom-based drugs have been used for hundreds of years in human history. Nevertheless, the venom-origin of the anti-cancer drug do rarely appear in the pharmaceutical market; and this is due to the fact that the mechanism of action for a large number of the venom drug such as venom-based peptide is not clearly understood. In this review, we focus on discussing some identified venom-based peptides and their anti-cancer mechanisms including the blockade of cancer cell proliferation, invasion, angiogenesis, and metastasis (hallmarks of cancer) to fulfill the gap which is hindering their use in cancer therapy. Furthermore, it also highlights the importance of immunotherapy based on venom peptide. Overall, this review provides readers for further understanding the mechanism of venom peptide and elaborates on the need to explore peptide-based therapeutic strategies.

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Section: Future Prospectsmentioning

confidence: 99%

Venom-based peptide therapy: insights into anti-cancer mechanism

Mahadevappa

Kwok

2017

Oncotarget

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“…As a result of these promising findings, scorpion venom peptides may be used to target a variety of hallmarks involved in cancer cell development and invasion. (Mikaelian et al 2020) Wong et al illustrated the efficacy of peptides and toxins isolated from various natural sources in killing cancer cells, the selectivity of these agents towards individual anti-cancer processes, and the potential of conjugated peptides as a new therapeutic approach (Wong et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Scorpion Venom Peptide Smp24 Revealed Apoptotic and Antiangiogenic Activities in Solid-Ehrlich Carcinoma Bearing Mice

Fawzy

Nafie²,

Ali³

et al. 2023

Int J Pept Res Ther

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Scorpion venom contains various peptides that could be utilized to treat various diseases, including cancer. This study aimed to evaluate the anti-cancer activity of scorpion venom peptide (Smp24) using a solid Ehrlich Carcinoma (SEC) mice model. SEC model was established by subcutaneous transplantation of SEC cells into Swiss albino female mice afterward subcutaneous injection of the Smp24 peptide compared to 5-Fluorouracil (5-FU) as a standard drug. Various biochemical, hematological, histopathological, immunohistochemical, and molecular (western blotting and RT-PCR) assays were performed to evaluate the antitumor activity of Smp24. Results revealed that Smp24 peptide significantly reduced tumor volume. Interestingly, Smp24 peptide significantly restored normal body functions in cancer-treated groups by maintaining HB, RBC’s, and WBC’s levels, reducing the elevated serum ALT and AST, and increasing total protein and albumin as well as enhancing antioxidant status through reducing the level of MDA and NO and elevating GSH, SOD, and CAT levels. Moreover, it restored the normal morphology of the liver and kidney tissues and improved hematological parameters in cancer-treated animals. Smp24 induced apoptosis in SEC cells, through upregulation of caspase-3 and BAX and the downregulation of VEGF, Bcl-2, p53, PCNA, and Ki67. Moreover, results exhibited the apoptotic and antiangiogenic effects of Smp24 against SEC cancer cells. These findings supported our previous results about the anti-cancer efficacy of Smp24 and made it a good candidate for developing effective and safe anti-cancer agents.

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