2020
DOI: 10.21203/rs.3.rs-51731/v1
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Veno-venous-ECMO as a Platform to Evaluate Lung Lavage and Surfactant Replacement Therapy in an Animal Model of Severe ARDS

Abstract: Background: There are limited therapeutic options directed at the underlying pathological processes in acute respiratory distress syndrome (ARDS). Experimental therapeutic strategies have targeted the protective systems that become deranged in ARDS such as surfactant. Although results of surfactant replacement therapy (SRT) in ARDS have been mixed, questions remain incompletely answered regarding timing and dosing strategies of surfactant. Furthermore, there are only few truly clinically relevant ARDS models i… Show more

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(1 citation statement)
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“…Therefore, we assessed IL-6 and IL-8 in our study. We found similar or even higher interleukin levels in BAL compared to other animal models of ALI (26,28,(32)(33)(34). Additionally, the amount of released mediators correlates with the severity and onset of ALI.…”
Section: In Ammationsupporting
confidence: 74%
“…Therefore, we assessed IL-6 and IL-8 in our study. We found similar or even higher interleukin levels in BAL compared to other animal models of ALI (26,28,(32)(33)(34). Additionally, the amount of released mediators correlates with the severity and onset of ALI.…”
Section: In Ammationsupporting
confidence: 74%