Venlafaxin-induziertes Syndrom der inadäquaten ADH-Sekretion (SIADH) - Therapie mit Tolvaptan

Meyer, Ilka; Frank, Dario; Janssens, Uwe

doi:10.1055/s-0032-1305012

Cited by 4 publications

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“…However, after the significant initial increase in sodium levels, we experienced some difficulties in reaching normal values (7 days to arrive at 130 mmol/L, 13 days to arrive at 135 mmol/L): therefore we maintained the drug for a longer period with respect to the SALT population [10]. Recently Meyer et al administered tolvaptan in a severe hyponatremia (108 mmol/L) induced by the antidepressant venlafaxine, obtaining a more rapid, and possibly dangerous, rise in sodium levels (to 131 mmol/L in 2 days) [20]. A possible explanation of these discrepancies could be related to the complex effects of a NSAID to renal functions, not only in terms of potentiation of the AVP effects but also in terms of independent effects on glomerular filtration rate and tubular sodium reabsorption [21].…”

Section: Discussionmentioning

confidence: 99%

Syndrome of Inappropriate Antidiuretic Hormone Secretion and Ibuprofen, a Rare Association to Be Considered: Role of Tolvaptan

Artom

Oddo

Pende

et al. 2013

Case Reports in Endocrinology

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The association between the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and the use of nonsteroidal anti-inflammatory drugs (NSAIDs) is rare and has never been treated with an arginine vasopressin receptor antagonist. We report a unique case of SIADH associated with ibuprofen use and successfully treated with tolvaptan. A 76-year-old man came to our observation because of lumbar pain and epigastric discomfort. He was taking ibuprofen orally 400 mg bid as an analgesic treatment. Laboratory tests showed low levels of sodium (116 mmol/L) and chloride; a diagnosis of SIADH was formulated and ibuprofen was stopped immediately. Imaging tests allowed to rule out the presence of malignancies or cerebral and lung diseases. Slightly hypertonic saline infusion was administered for 3 days without significant sodium improvement; therefore, tolvaptan was started at the initial dose of 7.5 mg daily, doubled after 5 days. After 8 days of treatment the patient showed progressive increase of sodium levels up to normal values. In the following weeks tolvaptan was prescribed at progressively titrated dosage to full suspension; afterwards the sodium levels remained normal without any type of treatment.

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Section: Discussionmentioning

confidence: 99%

Syndrome of Inappropriate Antidiuretic Hormone Secretion and Ibuprofen, a Rare Association to Be Considered: Role of Tolvaptan

Artom

Oddo

Pende

et al. 2013

Case Reports in Endocrinology

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“…3 SIADH is associated with hyponatremia without edema and is caused either by stimulating the release of vasopressin or by potentiating its action on the renal tubules 4,5 and, in particular, with the well-known adverse effect of AD treatment with selective serotonin reuptake inhibitor (SSRI). 6 There are few reports regarding the onset time or frequency of AD-or AP-induced hyponatremia/SIADH, and those studies primarily focused on SSRIs or serotonin noradrenaline reuptake inhibitors (SNRIs), 7,8 whereas reports about other groups of or individual psychotropic drugs are insufficient.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Frequency and Onset Time of Hyponatremia/Syndrome of Inappropriate Antidiuretic Hormone Induced by Antidepressants or Antipsychotics

et al. 2021

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Background Hyponatremia and syndrome of inappropriate antidiuretic hormone (SIADH) is a potentially fatal adverse effect of antidepressants (ADs) and antipsychotics (APs), although its frequency and onset time have not been well documented. Objective To analyze the frequency and onset time of AD- or AP-induced hyponatremia/SIADH. Methods We used plural data-mining techniques to search the US Food and Drug Administration Adverse Event Reporting System (FAERS) database for reports on hyponatremia/SIADH induced by psychotropic drugs from January 2004 to June 2020. For each item, we assessed the reporting odds ratio, 95% CI, median onset time, and Weibull distribution parameters. Results We identified 36 422 reports related to hyponatremia/SIADH. Signals were detected for all psychotropic drugs that we analyzed, except for clozapine. The median onset time of total AD-induced hyponatremia/SIADH was shorter than that of AP. For all ADs and APs except clozapine, hazards were considered to be the early failure type. In contrast, the hazard of clozapine was considered to be the random failure type. The limitations of this study included several reporting biases and the presence of confounding variables, particularly age. Conclusion and Relevance Most ADs and APs were found to be associated with a risk for hyponatremia/SIADH. In addition, sufficient attention should be paid to signs of hyponatremia/SIADH in the early phase when most ADs and APs are administered. These data are potentially useful for determining AD- or AP-induced hyponatremia/SIADH in the early stage and for preventing its further aggravation into a serious condition.

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Epileptic Seizures Under Antidepressive Drug Treatment: Systematic Review

Steinert

Fröscher²

2017

Pharmacopsychiatry

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Venlafaxin-induziertes Syndrom der inadäquaten ADH-Sekretion (SIADH) - Therapie mit Tolvaptan

Cited by 4 publications

References 0 publications

Syndrome of Inappropriate Antidiuretic Hormone Secretion and Ibuprofen, a Rare Association to Be Considered: Role of Tolvaptan

Syndrome of Inappropriate Antidiuretic Hormone Secretion and Ibuprofen, a Rare Association to Be Considered: Role of Tolvaptan

Analysis of the Frequency and Onset Time of Hyponatremia/Syndrome of Inappropriate Antidiuretic Hormone Induced by Antidepressants or Antipsychotics

Epileptic Seizures Under Antidepressive Drug Treatment: Systematic Review

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