Velocity of tumor spontaneous expansion predicts long-term outcomes for diffuse low-grade gliomas

Pallud, Johan; Blonski, Marie; Mandonnet, Emmanuel; Audureau, Étienne; Fontaine, Denys; Sanai, Nader; Bauchet, Luc; Peruzzi, P; Frénay, M.; Colin, Philippe; Guillevin, Rémy; Bernier, V.; Baron, Marie‐Hélène; Guyotat, Jacques; Duffau, Hugues; Taillandier, Luc; Laurent, Césari

doi:10.1093/neuonc/nos331

Cited by 136 publications

(141 citation statements)

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“…By contrast, VDE, which did not appear to be better than the choline/ creatine ratio in our work, has been considered in other studies as an independent predictive factor of anaplastic transformation [46] and should be considered in further studies, especially if tridimensional volumetric analysis is available. Furthermore, new MRI modalities could be used to improve the ability to predict anaplastic transformation, such as parametric response mapping (PRM) based on relative rCBV in perfusion MR, which is a good predictive factor for the evolution of high-grade gliomas [47].…”

Section: Discussioncontrasting

confidence: 65%

Prediction of anaplastic transformation in low-grade oligodendrogliomas based on magnetic resonance spectroscopy and 1p/19q codeletion status

et al. 2015

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The aim of this study was to assess whether combining multimodal magnetic resonance imaging (MRI) with the determination of the 1p/19q codeletion status could improve the ability to predict anaplastic transformation in low-grade oligodendrogliomas. Twenty patients with grade II oligodendrogliomas were followed-up using multimodal MR [proton MR spectroscopy (MRS), perfusion, and conventional MR imaging]. All patients diagnoses were histologically proven, and 1p/19q codeletion status was analyzed for all patients. Median follow-up was 30.5 ± 11.4 months. Anaplastic transformation was observed in six patients. The only MRI feature that was associated with anaplastic transformation was an elevation of the choline/creatine ratio >2.4 which was observed in 4 out of 6 patients with anaplastic transformation versus 1 out of 14 patients without anaplastic transformation. In patients without 1p/19q codeletion, an elevation of the choline/creatine ratio >2.4 was associated with the occurrence of anaplastic transformation in all cases (4 out of 4 patients), with a mean time of 12 months. In contrast, in patients with a 1p/19q codeletion, no anaplastic transformation was observed in the patient who had an elevation of >2.4 of the choline/creatine ratio and two patients demonstrated an anaplastic transformation without any elevation of this ratio.Prospective validation in a larger series is needed, yet the present study suggests that combining data from in vivo proton MRS and genetic analysis could be a promising strategy to predict time to anaplastic transformation at the individual level in patients with low-grade oligodendrogliomas and may help deciding when chemotherapy and/or radiotherapy should be initiated in these tumors.

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Section: Discussioncontrasting

confidence: 65%

Prediction of anaplastic transformation in low-grade oligodendrogliomas based on magnetic resonance spectroscopy and 1p/19q codeletion status

et al. 2015

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“…21 The impaired overall survival in the group of older patients may at least partially be explained by differences in surgical treatment. 21 The impaired overall survival in the group of older patients may at least partially be explained by differences in surgical treatment.…”

Section: Discussionmentioning

confidence: 99%

Age and surgical outcome of low-grade glioma in Sweden

et al. 2018

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“…In fact, low-grade gliomas are rarely radiologically stable. Careful imaging analysis reveals their average growth rate of 5 mm/year2 3; a growth rate above 8 mm per year is associated with a poor prognosis 2…”

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Contemporary management of low-grade glioma: a paradigm shift in neuro-oncology

Hayhurst

2017

Pract Neurol

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Supratentorial diffuse intrinsic low-grade gliomas represent a distinct but heterogenous group of tumours, with the propensity to grow and to differentiate into malignant tumours. They have been historically viewed in the 'benign' spectrum of intrinsic brain tumours, so a watch-and-wait policy was often adopted. With recent advances in our understanding of the natural history of these tumours, combined with advances in surgical technique, an aggressive approach is now recommended. Increasing quality evidence of the impact of tumour resection and multicentre trials of adjuvant radiotherapy and chemotherapy have led to a new algorithm for low-grade glioma management. This review aims to outline the emerging evidence that has shifted neuro-oncology practice.

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Velocity of tumor spontaneous expansion predicts long-term outcomes for diffuse low-grade gliomas

Abstract: Independent of the molecular status, the spontaneous velocity of diametric expansion allows the identification of rapidly growing diffuse low-grade gliomas (at higher risk of worsened evolution) during the pretherapeutic period and without delaying treatment.

Cited by 136 publications

References 27 publications

Prediction of anaplastic transformation in low-grade oligodendrogliomas based on magnetic resonance spectroscopy and 1p/19q codeletion status

Prediction of anaplastic transformation in low-grade oligodendrogliomas based on magnetic resonance spectroscopy and 1p/19q codeletion status

Age and surgical outcome of low-grade glioma in Sweden

Contemporary management of low-grade glioma: a paradigm shift in neuro-oncology

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Velocity of tumor spontaneous expansion predicts long-term outcomes for diffuse low-grade gliomas

Abstract: Independent of the molecular status, the spontaneous velocity of diametric expansion allows the identification of rapidly growing diffuse low-grade gliomas (at higher risk of worsened evolution) during the pretherapeutic period and without delaying treatment.

Cited by 136 publications

References 27 publications

Prediction of anaplastic transformation in low-grade oligodendrogliomas based on magnetic resonance spectroscopy and 1p/19q codeletion status

Prediction of anaplastic transformation in low-grade oligodendrogliomas based on magnetic resonance spectroscopy and 1p/19q codeletion status

Age and surgical outcome of low-grade glioma in Sweden

Contemporary management of low-­grade glioma: a paradigm shift in neuro-oncology

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Product

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Contemporary management of low-grade glioma: a paradigm shift in neuro-oncology