Vein pretreatment with magnesium sulfate to prevent pain on injection of propofol is not justified

Agarwal, Anil; Dhiraj, Sanjay; Raza, Mohsin; Pandey, Ravinder Kumar; Pandey, Chandra Kant; Singh, Prabhat Kumar; Singh, Uttam; Gupta, Devendra

doi:10.1007/bf03018771

Cited by 29 publications

(25 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…injection of propofol in the lidocaine group was 8% and it was similar to the results of Pang and colleagues 12 who reported it to be 11%. But, in some other studies higher incidences, such as 18% 13 or 42%, 11 have been reported. In these studies, the vein on the dorsum of the hand and the pneumatic tourniquet technique was used, as in the present study.…”

Section: Discussionmentioning

confidence: 96%

“…It was different from the previous studies that the incidence of pretreatment pain of lidocaine and control groups was unexpectedly high in our study. 11 In our study, the overall incidence of pain during i.v. injection of propofol in the lidocaine group was 8% and it was similar to the results of Pang and colleagues 12 who reported it to be 11%.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of intravenous acetaminophen and lidocaine on propofol injection pain

Canbay

Çelebi

Arun

et al. 2008

British Journal of Anaesthesia

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Efficacy of intravenous acetaminophen and lidocaine on propofol injection pain

Canbay

Çelebi

Arun

et al. 2008

British Journal of Anaesthesia

View full text Add to dashboard Cite

show abstract

“…Magnesium is not only the physiological calcium channel blocker, but also an antagonizer of NMDA receptors, which may interfere in the ion channels of K + and Ca 2+ , resulting in reduction of pain perception [20] . In previous studies [5,21,22] , pretreatment with magnesium sulfate was effective in the prevention of propofol-induced pain without considering injection pain from magnesium itself. Incidence of propofol injection pain in a study by Honarmand et al was 34% with magnesium sulphate 2.48 mmol pretreatment [21] .…”

Section: Discussionmentioning

confidence: 97%

“…As shown in previous data, the incidence of propofol-induced pain varies between 28% and 90% in adults [1,2] . Efforts to relieve this pain have been attempted like diluting the propofol solution [3] , addition of lidocaine and pretreatment with ondansetron [4] , magnesium sulfate [5] , opioids, parecoxib [6] , nitroglycerin [7] , and dexmedetomidine [8] . However, none have been found to be totally convenient and effective.…”

mentioning

confidence: 99%

Efficacy of different fluids preload on propofol injection pain: A randomized, controlled, double-blinded study

Yuan

Luo

Liu

et al. 2016

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

View full text Add to dashboard Cite

Injection pain of propofol remains a common clinical problem. Previous studies demonstrated that propofol injection pain was alleviated by applying nitroglycerin ointment to the skin of injection site, which inspires us to test whether venous vasodilation induced by fluid preload could alleviate the pain. Different types or volumes of fluid preload were compared. 200 ASA I-II adult patients were randomly assigned to five groups of 40 each. A 20 G cannula was established on the dorsum or wrist of the hand. When fluid preload given with Plasma-Lyte A 100 mL (P100 group), 250 mL (P250 group), 500 mL (P500 group), 0.9% saline 500 mL (N500 group) or Gelofusine 500 mL (G500 group) was completed within 30 min, respectively, Propofol (0.5 mg/kg, 1%) was injected at a rate of 0.5 mL/s. A blind investigator assessed the pain using a four-point scale. Incidence of pain in P100, P250, and P500 groups was 87.5%, 57.5% and 35%, respectively (P<0.05). The median pain intensity score was significantly lower in P500 group than that in P250 and P100 groups (P<0.05 and P<0.01, respectively). Comparison of the effect of different types of solution preload indicated that the highest incidence of pain was in N500 group (62.5%) (N500 vs. P500, P=0.014; N500 vs. G500, P=0.007). The median pain intensity score in N500 group was higher than that in P500 group (P<0.05) and G500 group (P<0.05). There was no significant difference between P500 and G500 groups. It is suggested that Plasma-Lyte A or Gelofusine preload with 500 mL before propofol injection is effective in alleviating propofol-induced pain.

show abstract

“…Furthermore, elevated ionic strength (for example, MgSO 4 or NaCl) is used in models of muscle and visceral "pain" (Fukawa et al, 1980;Gyires and Torma, 1984;Graven-Nielsen and Mense, 2001). Indeed, injections of MgSO 4 in the clinic are reported as being intensely painful (Agarwal et al, 2004), and NaCl produces a very familiar "burning" pain when applied to injured tissue, hence the phrase "rubbing salt into wounds." These disturbances in extracellular ion concentrations are perceived as painful because they activate nociceptive sensory neurons.…”

Section: Introductionmentioning

confidence: 99%

Extracellular Cations Sensitize and Gate Capsaicin Receptor TRPV1 Modulating Pain Signaling

Ahern¹,

Brooks²,

Miyares³

et al. 2005

J. Neurosci.

163

145

View full text Add to dashboard Cite

Transient receptor potential (TRP) channels detect diverse sensory stimuli, including alterations in osmolarity. However, a molecular detector of noxious hypertonic stimuli has not yet been identified. We show here that acute pain-related behavior evoked by elevated ionic strength is abolished in TRP vanilloid subtype 1 (TRPV1)-null mice and inhibited by iodoresiniferatoxin, a potent TRPV1 antagonist. Electrophysiological recordings demonstrate a novel form of ion channel modulation by which extracellular Na ϩ , Mg 2ϩ , and Ca 2ϩ ions sensitize and activate the capsaicin receptor, TRPV1. At room temperature, increasing extracellular Mg 2ϩ (from 1 to 5 mM) or Na ϩ (ϩ50 mM) increased ligand-activated currents up to fourfold, and 10 mM Mg 2ϩ reduced the EC 50 for activation by capsaicin from 890 to 450 nM. Moreover, concentrations of divalent cations Ͼ10 mM directly gate the receptor. These effects occur via electrostatic interactions with two glutamates (E600 and E648) formerly identified as proton-binding residues. Furthermore, phospholipase C-mediated signaling enhances the effects of cations, and physiological concentrations of cations contribute to the bradykinin-evoked activation of TRPV1 and the sensitization of the receptor to heat. Thus, the modulation of TRPV1 by cationic strength may contribute to inflammatory pain signaling.

show abstract

Vein pretreatment with magnesium sulfate to prevent pain on injection of propofol is not justified

Cited by 29 publications

References 14 publications

Efficacy of intravenous acetaminophen and lidocaine on propofol injection pain

Efficacy of intravenous acetaminophen and lidocaine on propofol injection pain

Efficacy of different fluids preload on propofol injection pain: A randomized, controlled, double-blinded study

Extracellular Cations Sensitize and Gate Capsaicin Receptor TRPV1 Modulating Pain Signaling

Contact Info

Product

Resources

About