Veillonella Bacteremia in a Patient With Metastatic Colorectal Carcinoma

Abstract

Colorectal carcinoma has increasingly been reported to be associated with gut microbial dysbiosis. Bacteroides , Fusobacterium , Faecalibacterium , Blautia , etc., are gut microbes commonly associated with colorectal carcinoma. Gut microbial dysregulation secondary to infectious, inflammatory, toxin exposure or change in dietary habits coupled with the disruption of the inner mucosal layer overlying the luminal epithelium is hypothesized as the inciting events leading to microbial invasion and subsequent tumorigenesis. Although the precise mechanism is unclear, disruption of normal host responses like inflammation, apoptosis, cellular proliferation, free radical injury, production of oncogenic toxins, etc., is postulated to play a role. We report a case of Veillonella bacteremia in a patient with metastatic colorectal carcinoma without a preceding history of periodontal disease. The patient was managed with ampicillin-sulbactam, which was followed by subsequent negative blood cultures. This case report signifies the association of gut microbiota like Veillonella with colorectal carcinoma and the importance of subsequent screening for colorectal cancer following Veillonella bacteremia .

Relationship between gut microbiota and thyroid function: a two-sample Mendelian randomization study

“…Based on these findings, it is conceivable that Oscillospira , by generating short-chain fatty acids and reducing BMI, might exert regulatory influence on TSH levels. Furthermore, Veillonella genus, a non-motile anaerobic Gram-negative diplococcus, resides within the human gastrointestinal tract ( 52 ). Discrepancies in microbial composition have been noted between patients afflicted by primary hypothyroidism and healthy individuals ( 10 ).…”