VEGFR2 inhibition hampers breast cancer cell proliferation &lt;i&gt;via&lt;/i&gt; enhanced mitochondrial biogenesis

Ni, Hao; Guo, Min; Zhang, Xuepei; Jiang, Lei; Tan, Shuai; Yuan, Jing; Cui, Huanhuan; Zhang, Junhao; Schlisio, Susanne; Ma, Chao; Liao, Wangjun; Nistér, Monica; Chen, Chunlin; Li, Shuijie; N, Li

doi:10.20892/j.issn.2095-3941.2020.0151

Cited by 19 publications

(14 citation statements)

References 32 publications

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“…92 This is because they are the three most crucial growth factor receptors with direct implication in cancerous cell lines. 93 Some designed quinoline-based inhibitors used in the treatment of different types of cancers are lenvatinib 73 , 94 tivozanib, 74 , 95 Ki8751 75 , 96 pelitinib 76 , 97 neratinib 77 , 98 pyrotinib 78 , 99,100 cabozantinib 32 , 101,102 and foretinib 33 . 103 They are ligands with good binding affinity to these growth factor receptors, selectively or collectively.…”

Section: Synthesis Of Quinoline Derivativesmentioning

confidence: 99%

Recent advances in chemistry and therapeutic potential of functionalized quinoline motifs – a review

2022

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Section: Synthesis Of Quinoline Derivativesmentioning

confidence: 99%

Recent advances in chemistry and therapeutic potential of functionalized quinoline motifs – a review

2022

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“…Moreover, Ki8751, a vascular endothelial growth factor (VEGF) receptor 2 inhibitor, induces ROS generation and apoptosis of breast cancer cells by decreasing the phosphorylation of AKT and peroxisome proliferator-activated receptor-γ coactivator 1-α (PGC1α), which improves the nucleus translocation of PGC1α and mitochondrial transcription factor A (TFAM) expression, and mitochondrial biogenesis [ 173 ]. 14-(3-Fluorophenyl)-8,13,13b,14-tetrahydroindolo[2′,3′:3,4]pyrido[2,1-b]quinazolin-5(7H)-one, an evodiamine derivative, triggers apoptosis of gastric cancer cells by suppressing PI3K/AKT [ 174 ].…”

Section: Akt Modulates Cell Functionsmentioning

confidence: 99%

The Impact of Oxidative Stress and AKT Pathway on Cancer Cell Functions and Its Application to Natural Products

et al. 2022

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Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating several cell functions of cancer cells. Several natural products modulate both oxidative stress and AKT for anticancer effects. However, the impact of natural product-modulating oxidative stress and AKT on cell functions lacks systemic understanding. Notably, the contribution of regulating cell functions by AKT downstream effectors is not yet well integrated. This review explores the role of oxidative stress and AKT pathway (AKT/AKT effectors) on ten cell functions, including apoptosis, autophagy, endoplasmic reticulum stress, mitochondrial morphogenesis, ferroptosis, necroptosis, DNA damage response, senescence, migration, and cell-cycle progression. The impact of oxidative stress and AKT are connected to these cell functions through cell function mediators. Moreover, the AKT effectors related to cell functions are integrated. Based on this rationale, natural products with the modulating abilities for oxidative stress and AKT pathway exhibit the potential to regulate these cell functions, but some were rarely reported, particularly for AKT effectors. This review sheds light on understanding the roles of oxidative stress and AKT pathway in regulating cell functions, providing future directions for natural products in cancer treatment.

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“…VEGF signals vascular development and angiogenesis mainly by binding to VEGF receptor family member 2 (VEGFR‐2). Recent reports reveal and support that VEGF is critical in maintaining cell proliferative potential, and inhibition of VEGFR significantly increases cellular senescence in metastatic breast and colon cancer cells [8–10] …”

Section: Introductionmentioning

confidence: 98%

“…Recent reports reveal and support that VEGF is critical in maintaining cell proliferative potential, and inhibition of VEGFR significantly increases cellular senescence in metastatic breast and colon cancer cells. [8][9][10] Schiff bases and their metal complexes have gained attention due to their structural versatility, ease of synthesis, and diverse biological applications including antiinflammatory, [11] antibacterial, [12] anti-aging, [13] and anticancer. [14][15][16] In addition, the imine bond (À C=NÀ ) present in Schiff bases provides unique opportunities to bind with different nucleophiles and electrophiles, inhibiting enzymes or DNA replication.…”

Section: Introductionmentioning

confidence: 99%

Development of Isatin‐Based Schiff Bases Targeting VEGFR‐2 Inhibition: Synthesis, Characterization, Antiproliferative Properties, and QSAR Studies

Seliem

Panda

Girgis³

et al. 2022

ChemMedChem

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Three sets of isatin-based Schiff bases were synthesized utilizing the molecular hybridization approach. Some of the synthesized Schiff bases show significant to moderate antiproliferative properties against MCF7 (breast), HCT116 (colon), and PaCa2 (pancreatic) cancer cell lines with potency compared to reference drugs 5-fluorouracil (5-FU) and Sunitinib. Among all, compound 17 f-5-methylindolin-2-one) exhibits promising antiproliferative properties against the MCF7 cancer cell line with 2.1-fold more potency than Sunitinib. However, among all the synthesized compounds, three (5-methylisatin derivatives) were the most effective against HCT116 in comparison to 5-FU. Compound 17 f exhibited the highest anti-angiogenic effect on the vasculature as it significantly reduced BV from 43 mm to 2 mm in comparison to 5.7 mm for Sunitinib and flow cytometry supports the arrest of the cell cycle at G1/S phases. In addition, compound 17 f also showed high VEGFR-2 inhibition properties against breast cancer cell lines. Robust 2D-QSAR studies supported the biological data.

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VEGFR2 inhibition hampers breast cancer cell proliferation <i>via</i> enhanced mitochondrial biogenesis

Cited by 19 publications

References 32 publications

Recent advances in chemistry and therapeutic potential of functionalized quinoline motifs – a review

Recent advances in chemistry and therapeutic potential of functionalized quinoline motifs – a review

The Impact of Oxidative Stress and AKT Pathway on Cancer Cell Functions and Its Application to Natural Products

Development of Isatin‐Based Schiff Bases Targeting VEGFR‐2 Inhibition: Synthesis, Characterization, Antiproliferative Properties, and QSAR Studies

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