VEGF induces proliferation of human hair follicle dermal papilla cells through VEGFR-2-mediated activation of ERK

Li, Wei; Man, Xiao‐Yong; Li, Chunming; Chen, Jiaqi; Zhou, Jiong; Cai, Sheng; Zhang, Lu; Zheng, Min

doi:10.1016/j.yexcr.2012.05.003

Cited by 101 publications

(94 citation statements)

References 34 publications

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“…EGF and VEGF demonstrated stim-ulation of DP proliferation [60,61]. However, these factors failed to maintain speciic DP markers (unpublished data).…”

Section: Dermal Papilla Cells and Their Inductive Propertiesmentioning

confidence: 90%

Hair Follicle Reconstruction and Stem Cells

Kalabusheva¹,

Chermnykh²,

Terskikh³

et al. 2017

Hair and Scalp Disorders

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De novo hair follicle (HF) formation in embryonic skin and hair growth in postnatal skin are the result of epithelial-mesenchymal interactions between specialized mesenchymal dermal papilla (DP) and epithelial stem cells that give rise to hairs. Adult HF is a valuable source of diferent lineages of stem cells (SCs) with morphogenetic potential. Epithelial stem cells are residing in the special compartment of HF (the bulge) and can be mobilized to regenerate the new follicle with each hair cycle and to reepithelialize epidermis during wound repair. This review summarizes the current knowledge on key characteristics of HF SC populations in terms of regenerative potential. General biological principles that govern the mesenchymal-epithelial interactions within the HF and the signaling pathways that control HF development are discussed. The main focus is on recent approaches to reconstruct folliculogenesis in vitro and perspectives of the tissue engineering in alopecia therapy.

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“…EGF and VEGF demonstrated stim-ulation of DP proliferation [60,61]. However, these factors failed to maintain speciic DP markers (unpublished data).…”

Section: Dermal Papilla Cells and Their Inductive Propertiesmentioning

confidence: 90%

Hair Follicle Reconstruction and Stem Cells

Kalabusheva¹,

Chermnykh²,

Terskikh³

et al. 2017

Hair and Scalp Disorders

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“…VEGF-R2 is expressed by different cells, including endothelial cells, 55) keratinocytes, 56) cancer cells 26) and hair follicle cells. 27,28,57) VEGF has been known to increase the cell proliferation of DPCs and ORS, which was attenuated by VEGF-R2 neutralizing antibody. These reports suggest that activation of the VEGF-R2 pathway is required for the proliferation of DPCs.…”

Section: Discussionmentioning

confidence: 99%

“…27,28) We thus investigated whether apo-9′-fucoxanthinone could affect the level of VEGF-R2 in DPCs. When DPCs were treated with apo-9′-fucoxanthinone for 72 h, apo-9′-fucoxanthinone significantly increased the level of VEGF-R2 (Fig.…”

Section: Effect Of Apo-9′-fucoxanthinone On the 5α-reductase Activitymentioning

confidence: 99%

“…[24][25][26] The effect of VEGF is mediated by the binding of VEGF receptor-2 (VEGF-R2) and recent studies showed that VEGF-mediated proliferation effects have been observed in DPCs and outer root sheaths (ORS). 27,28) These studies suggest that the VEGF-R2 pathway may act as an activator in the proliferation of hair follicles cells. In addition, several growth factors, such as insulin-like growth factor-1, 29) fibroblast growth factor-5, 30) -7 31) and transforming growth factor-β (TGF-β) 32,33) have also been known to positively or negatively regulate hair growth.…”

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confidence: 95%

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Promotion Effect of Apo-9′-fucoxanthinone from <i>Sargassum muticum</i> on Hair Growth <i>via</i> the Activation of Wnt/β-Catenin and VEGF-R2

Kang

Yoo

Hyun

et al. 2016

Biological & Pharmaceutical Bulletin

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This study was conducted to evaluate the effects of Sargassum muticum extract and apo-9′-fucoxanthinone, a principal component of S. muticum, on hair growth. When rat vibrissa follicles were treated with S. muticum extract for 21 d, the hair-fiber lengths for the vibrissa follicles increased significantly. Treatment with the S. muticum extract and the EtOAc fraction of the S. muticum extract markedly increased the proliferation of dermal papilla cells (DPCs) and decreased the 5α-reductase activity. In addition, the EtOAc fraction of the S. muticum extract significantly promoted anagen initiation in C57BL/6 mice. Especially, apo-9′-fucoxanthinone, an active constituent from the S. muticum extract, caused an increase in DPC proliferation and a decrease in 5α-reductase activity. To elucidate the molecular mechanisms of apo-9′-fucoxanthinone on the proliferation of DPCs, we examined the level of various signaling proteins. Apo-9′-fucoxanthinone increased the level of vascular endothelial growth factor receptor-2 (VEGF-R2), Wnt/β-catenin signaling proteins such as phospho(ser9)-glycogen synthase kinase-3β (GSK-3β) and phospho(ser552)-β-catenin, whereas apo-9′-fucoxanthinone did not affect the transforming growth factor-β (TGF-β) signaling proteins such as Smad2/3. These results suggest that apo-9′-fucoxanthinone from S. muticum could have the potential for hair growth with DPC proliferation via the activation of Wnt/β-catenin signaling and the VEGF-R2 pathway.

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“…VEGF binds to VEGF receptor-1 (VEGFR-1, also known as Flt-1) and VEGFR-2 (also known as KDR/Flk-1). Epidermal keratinocytes secrete biologically active VEGF in vitro, while cultured epidermal sheets produce large amounts of VEGF (Li et al, 2012). In addition, VEGF widespread exists in many organs in the body of humans and animals, which is essential inducible factor in other physiological and pathological angiogenesis and plays a local regulatory role (Lin et al, 2012) VEGF is a key factor in promoting angiogenesis, as well as influencing diverse cell functions including cell survival, proliferation and the generation of nitric oxide and prostacyclin (Ford and Amore, 2012) The perifollicular capillary network is coupled to the hair cycle, increasing during the anagen phase and then regressing during the catagen and telogen phases (Lee et al, 2010b).…”

Section: Vascular Endothelial Growth Factor (Vegf)mentioning

confidence: 99%

Progress in Relevant Growth Factors Promoting the Growth of Hair Follicle

Valerie¹

2012

American Journal of Animal and Veterinary Sciences

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Abstract:Hair is a protective appendage on the body that is considered accessory structure of the integument. Hair follicle development takes place during fetal skin development and relies on tightly regulated ectodermal-mesodermal interactions. The morphological changes of the hair cycle have been very clear that hair morphogenesis and epidermal development are orchestrated by an array of growth factors. In this review, we summarize the major growth factors involved in promoting growth of hair follicles.

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VEGF induces proliferation of human hair follicle dermal papilla cells through VEGFR-2-mediated activation of ERK

Cited by 101 publications

References 34 publications

Hair Follicle Reconstruction and Stem Cells

Hair Follicle Reconstruction and Stem Cells

Promotion Effect of Apo-9′-fucoxanthinone from <i>Sargassum muticum</i> on Hair Growth <i>via</i> the Activation of Wnt/β-Catenin and VEGF-R2

Progress in Relevant Growth Factors Promoting the Growth of Hair Follicle

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