VEGF Gene Haplotypes Are Associated With Sarcoidosis

Transforming growth factor- gene polymorphisms in different phenotypes of sarcoidosis

“…This has been demonstrated for BTNL-2 (butyrophilinlike 2), which until now is the gene best associated with sarcoidosis and preferentially with a chronic course [10,23]. The division into the two subgroups ''acute'' and ''chronic'' as we have defined it might have been arbitrary.…”

“…For the statistical analysis, patients with chronic course were defined as either 1) having symptoms over a time span of 2 yrs or more or 2) having had a minimum of two episodes in a lifetime, as described previously [9][10][11]. Acute sarcoidosis was defined as only one episode of a clinically acute sarcoidosis, which had totally resolved and had not relapsed in the follow-up time.…”

VEGF gene polymorphism and response to intravitreal bevacizumab and triple therapy in age-related macular degeneration

“…The VEGF rs699946 captures and reflects one SNP on the promoter region (rs833060) and four SNPs on the VEGF gene (rs833068, rs833069, rs3024997, rs3025000) with high linkage disequilibrium. Because some of these SNPs correlate with VEGF production [45], a VEGF genotype might affect visual prognosis via the amount of VEGF produced. In addition to the amount of VEGF, the ratio of various VEGF isoforms can affect the prognosis of AMD because each VEGF isoform has its own role in both pathologic and physiologic neovascularization [46].…”

Association between Genetic Variants of the <b><i>VEGFR-2</i></b> Gene and the Risk of Developing Endometriosis in Northern Chinese Women

“…The -604C allele has been shown to have 68% less luciferase activity than the -604T allele [17]. Several studies have investigated the relationship between this SNP and the risk of developing disease, but the results are variable [23,24,25,26]. Both the IVS6+54C/T and the IVS25-92A/G polymorphisms are located within intron regions in the VEGFR-2 gene.…”