VEGF-C et vaisseaux lymphatiques

Ndiaye, Papa Diogop; Pagès, Gilles

doi:10.1051/medsci/2019002

Med Sci (Paris)

2019

DOI: 10.1051/medsci/2019002

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VEGF-C et vaisseaux lymphatiques

Papa Diogop Ndiaye

Gilles Pagès

Abstract: Le système lymphatique est formé de vaisseaux qui drainent les liquides interstitiels dans tout l’organisme. La circulation de la lymphe dans les vaisseaux lymphatiques est unidirectionnelle : des tissus vers les ganglions lymphatiques puis les veines. Les ganglions sont des filtres mécaniques mais aussi des barrières immunitaires pouvant bloquer la progression de certains pathogènes et des cellules cancéreuses. Cependant, la plupart des études portant sur le système lymphatique et la cancérogenèse mettent en … Show more

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Cited by 2 publications

References 49 publications

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Reprogramming of sentinel lymph node microenvironment during tumor metastasis

Hung

2022

J Biomed Sci

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Metastasis is a major cause of death in patients with cancer. The two main routes for cancer cell dissemination are the blood and lymphatic systems. The underlying mechanism of hematogenous metastasis has been well characterized in the past few decades. However, our understanding of the molecular basis of lymphatic metastasis remains at a premature stage. Conceptually, cancer cells invade into lymphatic capillary, passively move to collecting lymphatic vessels, migrate into sentinel lymph node (SLN;, the first lymph node to which cancer cells spread from the primary tumor), and enter the blood circulatory system via the subclavian vein. Before arriving, cancer cells release specific soluble factors to modulate the microenvironment in SLN to establish a beachhead for successful colonization. After colonization, cancer cells inhibit anti-tumor immunity by inducing the recruitment of regulatory T cell and myeloid-derived suppressor cells, suppressing the function of dendritic cell and CD8+ T cell, and promoting the release of immunosuppressive cytokines. The development of novel strategies to reverse cancer cell-triggered SLN remodeling may re-activate immunity to reduce beachhead buildup and distant metastasis. In addition to being a microanatomic location for metastasis, the SLN is also an important site for immune modulation. Nanotechnology-based approaches to deliver lymph node-tropic antibodies or drug-conjugated nanoparticles to kill cancer cells on site are a new direction for cancer treatment. Conversely, the induction of stronger immunity by promoting antigen presentation in lymph nodes provides an alternate way to enhance the efficacy of immune checkpoint therapy and cancer vaccine. In this review article, we summarize recent findings on the reprogramming of SLN during lymphatic invasion and discuss the possibility of inhibiting tumor metastasis and eliciting anti-tumor immunity by targeting SLN.

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Reprogramming of sentinel lymph node microenvironment during tumor metastasis

Hung

2022

J Biomed Sci

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Lymphatic Endothelial Markers and Tumor Lymphangiogenesis Assessment in Human Breast Cancer

Chen

Luo

et al. 2021

Diagnostics

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Metastasis via lymphatic vessels or blood vessels is the leading cause of death for breast cancer, and lymphangiogenesis and angiogenesis are critical prerequisites for the tumor invasion–metastasis cascade. The research progress for tumor lymphangiogenesis has tended to lag behind that for angiogenesis due to the lack of specific markers. With the discovery of lymphatic endothelial cell (LEC) markers, growing evidence demonstrates that the LEC plays an active role in lymphatic formation and remodeling, tumor cell growth, invasion and intravasation, tumor–microenvironment remodeling, and antitumor immunity. However, some studies have drawn controversial conclusions due to the variation in the LEC markers and lymphangiogenesis assessments used. In this study, we review recent findings on tumor lymphangiogenesis, the most commonly used LEC markers, and parameters for lymphangiogenesis assessments, such as the lymphatic vessel density and lymphatic vessel invasion in human breast cancer. An in-depth understanding of tumor lymphangiogenesis and LEC markers can help to illustrate the mechanisms and distinct roles of lymphangiogenesis in breast cancer progression, which will help in exploring novel potential predictive biomarkers and therapeutic targets for breast cancer.

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VEGF-C et vaisseaux lymphatiques

Cited by 2 publications

References 49 publications

Reprogramming of sentinel lymph node microenvironment during tumor metastasis

Reprogramming of sentinel lymph node microenvironment during tumor metastasis

Lymphatic Endothelial Markers and Tumor Lymphangiogenesis Assessment in Human Breast Cancer

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