Vegf-B

Li, Xuri; Lee, Chunsik; Tang, Zhongshu; Zhang, Fan; Arjunan, Pachiappan; Yang, Li; Xu, Hui; Kumar, Anil; Dong, Lijin

doi:10.4161/cam.3.4.9459

Cited by 76 publications

(48 citation statements)

References 67 publications

(124 reference statements)

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“…Moreover it is a survival factor for endothelial cells, pericytes, and smooth muscle cells [201, 218, 219]. Administration of small quantities of VEGF-B causes neuroprotection without causing adverse effects or vascular blood-brain barrier leakiness [220].…”

Section: Role Of Vegf In Alsmentioning

confidence: 99%

Roles of Vascular Endothelial Growth Factor in Amyotrophic Lateral Sclerosis

Pronto-Laborinho

Pinto

Carvalho

2014

BioMed Research International

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Amyotrophic lateral sclerosis (ALS) is a fatal devastating neurodegenerative disorder, involving progressive degeneration of motor neurons in spinal cord, brainstem, and motor cortex. Riluzole is the only drug approved in ALS but it only confers a modest improvement in survival. In spite of a high number of clinical trials no other drug has proved effectiveness. Recent studies support that vascular endothelial growth factor (VEGF), originally described as a key angiogenic factor, also plays a key role in the nervous system, including neurogenesis, neuronal survival, neuronal migration, and axon guidance. VEGF has been used in exploratory clinical studies with promising results in ALS and other neurological disorders. Although VEGF is a very promising compound, translating the basic science breakthroughs into clinical practice is the major challenge ahead. VEGF-B, presenting a single safety profile, protects motor neurons from degeneration in ALS animal models and, therefore, it will be particularly interesting to test its effects in ALS patients. In the present paper the authors make a brief description of the molecular properties of VEGF and its receptors and review its different features and therapeutic potential in the nervous system/neurodegenerative disease, particularly in ALS.

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Section: Role Of Vegf In Alsmentioning

confidence: 99%

Roles of Vascular Endothelial Growth Factor in Amyotrophic Lateral Sclerosis

Pronto-Laborinho

Pinto

Carvalho

2014

BioMed Research International

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“…Though VEGF-B is not essential for angiogenesis in most tissues and settings, it has been demonstrated to be a crucial survival factor for blood vessels [88, 89]. Due to the fact that VEGF-B shows only minor angiogenic activity, VEGF-B was shown to have a better safety profile as a neuroprotective survival molecule than VEGF-A and might therefore be a good therapeutic target for neurodegenerative diseases [90].…”

Section: The Vegfr-1 and -2 And Their Ligandsmentioning

confidence: 99%

“…Blockade of VEGFR-1 eliminates the inhibitory effect of VEGF-B on the expression of anti-apoptotic genes in RGCs, strongly suggesting that VEGFR-1 mediates the neuroprotective properties of VEGF-B in the retina. In contradiction to VEGF-A, VEGF-B lacks a general angiogenic activity (except in the heart), which makes it an ideal candidate for neuroprotective therapies without affecting the vascular system [89]. …”

Section: The Neurobiology Of Vegfr-1 and -2mentioning

confidence: 99%

Brain homeostasis: VEGF receptor 1 and 2—two unequal brothers in mind

Wittko-Schneider

Schneider

Plate

2013

Cell. Mol. Life Sci.

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Vascular endothelial growth factors (VEGFs), initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood. Therefore, the VEGF system serves as a promising therapeutic target for brain pathologies, but its simultaneous action on vascular cells paves the way for harmful side effects. To circumvent these deleterious effects, many studies have aimed to clarify whether VEGFs directly affect neural cells or if the effects are mediated secondarily via other cell types, like vascular cells. A great number of reports have shown the expression and function of VEGF receptors (VEGFRs), mainly VEGFR-1 and -2, in neural cells, where VEGFR-2 has been described as the major mediator of VEGF-A signals. This review aims to summarize and compare the divergent roles of VEGFR-1 and -2 during CNS development and homeostasis.

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“…24 Recently its participation in lipid transport and energy metabolism mediation was partially revealed, indicating its implication in lipids accumulation relevant metabolic diseases, e.g. the type 2 diabetes mellitus (T2DM).…”

Section: Introductionmentioning

confidence: 99%

Vascular endothelial growth factor-B: Impact on physiology and pathology

Zhu

Gao

et al. 2017

Cell Adhesion & Migration

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Angiogenesis plays an important role in controlling tissue development and maintaining normal tissue function. Dysregulated angiogenesis is implicated in the pathogenesis of a variety of diseases, particularly diabetes, cancers, and neurodegenerative disorders. As the major regulator of angiogenesis, the vascular endothelial growth factor (VEGF) family is composed of a group of crucial members including VEGF-B. While the physiological roles of VEGF-B remain debatable, increasing evidence suggests that this protein is able to protect certain type of cells from apoptosis under pathological conditions. More importantly, recent studies reveal that VEGF-B is involved in lipid transport and energy metabolism, implicating this protein in obesity, diabetes and related metabolic complications. This article summarizes the current knowledge and understanding of VEGF-B in physiology and pathology, and shed light on the therapeutic potential of this crucial protein.

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Vegf-B

Cited by 76 publications

References 67 publications

Roles of Vascular Endothelial Growth Factor in Amyotrophic Lateral Sclerosis

Roles of Vascular Endothelial Growth Factor in Amyotrophic Lateral Sclerosis

Brain homeostasis: VEGF receptor 1 and 2—two unequal brothers in mind

Vascular endothelial growth factor-B: Impact on physiology and pathology

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