VEGF and VEGF receptors are differentially expressed in chondrocytes

Bluteau, Gilles; Julien, Marion; Magne, David; Malléin-Gerin, Frédéric; Weiss, Pierre; Daculsi, Guy; Guicheux, Jérôme

doi:10.1016/j.bone.2006.09.024

Cited by 64 publications

(59 citation statements)

References 52 publications

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“…VEGF proteins are secreted by cells involved in skeletal development and repair, including EC, macrophages, fibroblasts, smooth muscle cells, osteoblasts and hypertrophic chondrocytes [13,14]. Different from bone development, the early stage of fracture repair is characterized by hematoma formation, which has strong proangiogenic properties, predominantly due to the presence of VEGF [15,16] (Fig.…”

Section: Vascular Endothelial Growth Factormentioning

confidence: 99%

Bringing new life to damaged bone: The importance of angiogenesis in bone repair and regeneration

Stegen

Gastel

Carmeliet

2015

Bone

369

278

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Bone has the unique capacity to heal without the formation of a fibrous scar, likely because several of the cellular and molecular processes governing bone healing recapitulate the events during skeletal development. A critical component in bone healing is the timely appearance of blood vessels in the fracture callus. Angiogenesis, the formation of new blood vessels from pre-existing ones, is stimulated after fracture by the local production of numerous angiogenic growth factors. The fracture vasculature not only supplies oxygen and nutrients, but also stem cells able to differentiate into osteoblasts and in a later phase also the ions necessary for mineralization. This review provides a concise report of the regulation of angiogenesis by bone cells, its importance during bone healing and its possible therapeutic applications in bone tissue engineering. This article is part of a Special Issue entitled "Stem Cells and Bone".

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Section: Vascular Endothelial Growth Factormentioning

confidence: 99%

Bringing new life to damaged bone: The importance of angiogenesis in bone repair and regeneration

Stegen

Gastel

Carmeliet

2015

Bone

369

278

View full text Add to dashboard Cite

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“…] receptors are present of a growing number of non-endothelial cells. For instance, VEGF receptors are expressed at detectable levels in non-endothelial cells types including skeletal myocytes, dental odontoblasts, retinal neurons, keratinocytes, chondrocytes, and neurons, and all of these cell types express VEGF either in response to hypoxia or as part of their differentiation program-suggesting the possibility of a VEGF autocrine loop [Sondell et al, 2000;Bluteau et al, 2007;Nishijima et al, 2007;Scheven et al, 2009;Bryan et al, 2008]. For instance, systemic VEGF neutralization in mice results in retinal apoptosis and degeneration attributed to an autocrine VEGF loop in Mü ller cells and a paracrine neuroprotective effect on the photoreceptors [Saint-Geniez et al, 2009].…”

Section: Common Side Effects Of Anti-angiogenic Therapymentioning

confidence: 99%

Anti‐angiogenic therapy: Adapting strategies to overcome resistant tumors

Mitchell

Bryan

2010

J of Cellular Biochemistry

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Healthy cells, as well as benign and malignant tumors, depend upon the body's blood supply to bring in oxygen and nutrients and carry away waste products. Using this property against tumors, anti-angiogenic therapy targets the tumor vasculature with the aim of starving the tumor, and has demonstrated exceptional clinical efficacy against a number of tumors. This review discusses the current state of knowledge regarding anti-angiogenic therapies presently available to patients, and garners from both preclinical and clinical literature the benefits and side effects associated with anti-angiogenic therapies, the unfortunate mechanisms of acquired resistance to these novel therapeutics, and highlights promising next generation anti-angiogenics that may overcome the limitations encountered with first generation therapies.

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“…Hypertrophic chondrocytes express and synthesize a number of VEGF isoforms, VEGF-A, VEGF-B, VEGF-C, VEGF-D and also express neuropilin-1, VEGF receptor-2 and VEGF receptor-3 (Bluteau et al, 2007). This autocrine/paracrine system will further encourage inwards penetration of the vascular endothelium (Peterson et al, 2002).…”

Section: The Role Of Angiogenic Factors In Early Bone Developmentmentioning

confidence: 99%

“…Although VEGFs' main effects are on endothelial cells, they also bind to VEGF receptors expressed on monocytes, neurons, chondrocytes and osteoblasts Storkebaum and Carmeliet, 2004;Bluteau et al, 2007). Apart from VEGFs' potent angiogenic effects they can induce haematopoietic stem cell recruitment from the bone marrow, monocyte chemoattraction, neuronal protection as well as bone formation Storkebaum and Carmeliet, 2004;Geiger et al, 2005;Peng et al, 2005).…”

Section: The Role Of Angiogenic Factors In Early Bone Developmentmentioning

confidence: 99%

Osteogenesis and angiogenesis: The potential for engineering bone

Kanczler

Oreffo²

2008

eCM

888

637

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The repair of large bone defects remains a major clinical orthopaedic challenge. Bone is a highly vascularised tissue reliant on the close spatial and temporal connection between blood vessels and bone cells to maintain skeletal integrity. Angiogenesis thus plays a pivotal role in skeletal development and bone fracture repair. Current procedures to repair bone defects and to provide structural and mechanical support include the use of grafts (autologous, allogeneic) or implants (polymeric or metallic). These approaches face significant limitations due to insufficient supply, potential disease transmission, rejection, cost and the inability to integrate with the surrounding host tissue.

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VEGF and VEGF receptors are differentially expressed in chondrocytes

Cited by 64 publications

References 52 publications

Bringing new life to damaged bone: The importance of angiogenesis in bone repair and regeneration

Bringing new life to damaged bone: The importance of angiogenesis in bone repair and regeneration

Anti‐angiogenic therapy: Adapting strategies to overcome resistant tumors

Osteogenesis and angiogenesis: The potential for engineering bone

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