Vegetation analysis of the Aswan–Allaqi road in the Southern Eastern Desert of Egypt indicates the dominance of Morettia philaeana, Aerva javanica, Fagonia indica, Salsola imbricata, Pulicarica crispa, Crotalaria aegyptiaca, Lotononis platycarpa, Citrullus colocynthis, Pulicaria incisa, Astragalus vogelii and Zygophyllum simplex. Four vegetation clusters are recognized after the application of the Two‐Way Indicator Species Analysis (TWIN‐SPAN). These clusters are named after the dominant species as follows: Fagonia indica – Aerva javanica, Salsola imbricata – Zilla spinosa, Salsola imbricata – Morettia philaeana and Salsola imbricata – Aerva javanica. Among the estimated soil variables in the present study, silt, clay, pH, EC, HCO3, CI−, and Ca2+ are important in characterizing the vegetation clusters.