Vegetables and Their Bioactive Compounds as Anti-Aging Drugs

Mechchate, Hamza; Allam, Aicha El; Omari, Nasreddine El; Shariati, Mohammad Ali; Wilairatana, Polrat; Mubarak, Mohammad S.; Bouyahya, Abdelhakim

doi:10.3390/molecules27072316

Cited by 23 publications

(19 citation statements)

References 167 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The distinctive architectures of PDNVs reveal their promise in the delivery of antiaging‐related medications, allowing them to inherit the inherent bioactive capabilities of the parent plants (Fang and Liu 2022, Mechchate et al 2022). PDNVs' lipid bilayer structure provides for loading hydrophobic anti‐aging medications, increasing drug bioavailability and allowing for the effective loading of hydrophilic pharmaceuticals, decreasing drug leakage, and reducing drug‐related adverse effects.…”

Section: The Prospects For Anti‐aging Treatments Based On Pdnvsmentioning

confidence: 99%

Plant‐derived nanovesicles offer a promising avenue for anti‐aging interventions

Meng,

Sun,

et al. 2024

Physiologia Plantarum

View full text Add to dashboard Cite

Over the past few years, the study of plant‐derived nanovesicles (PDNVs) has emerged as a hot topic of discussion and research in the scientific community. This remarkable interest stems from their potential role in facilitating intercellular communication and their unique ability to deliver biologically active components, including proteins, lipids, and miRNAs, to recipient cells. This fascinating ability to act as a molecular courier has opened up an entirely new dimension in our understanding of plant biology. The field of research focusing on the potential applications of PDNVs is still in its nascent stages. However, it has already started gaining traction due to the growing interest in its possible use in various branches of biotechnology and medicine. Their unique properties and versatile applications offer promising future research and development prospects in these fields. Despite the significant progress in our understanding, many unanswered questions and mysteries surround the mechanisms by which PDNVs function and their potential applications. There is a dire need for further extensive research to elucidate these mechanisms and explore the full potential of these fascinating vesicles. As the technology at our disposal advances and our understanding of PDNVs deepens, it is beyond doubt that PDNVs will continue to be a subject of intense research in anti‐aging therapeutics. This comprehensive review is designed to delve into the fascinating and multifaceted world of PDNV‐based research, particularly focusing on how these nanovesicles can be applied to anti‐aging therapeutics.

show abstract

Section: The Prospects For Anti‐aging Treatments Based On Pdnvsmentioning

confidence: 99%

Plant‐derived nanovesicles offer a promising avenue for anti‐aging interventions

Meng,

Sun,

et al. 2024

Physiologia Plantarum

View full text Add to dashboard Cite

show abstract

“…For example, activating autophagy through 3,4-dimethoxychalcone stimulates transcription factors E3 and EB [279]. On the other hand, vegetables and seaweeds as a resource for extracting bioactive molecules to be used as anti-senescence agents have also been reviewed [280,281]. Curcumin is also reported to have an anti-aging role in the treatment of aging-related diseases, cancer, and arthritis [282].…”

Section: Pharmacological and Nutraceutical Interventionsmentioning

confidence: 99%

Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting

et al. 2022

View full text Add to dashboard Cite

Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under appropriate conditions. The role of MSCs in tissue homeostasis, aging-related diseases, and cellular therapy is clinically suggested. As aging is a universal problem that has large socioeconomic effects, an improved understanding of the concepts of aging can direct public policies that reduce its adverse impacts on the healthcare system and humanity. Several studies of aging have been carried out over several years to understand the phenomenon and different factors affecting human aging. A reduced ability of adult stem cell populations to reproduce and regenerate is one of the main contributors to the human aging process. In this context, MSCs senescence is a major challenge in front of cellular therapy advancement. Many factors, ranging from genetic and metabolic pathways to extrinsic factors through various cellular signaling pathways, are involved in regulating the mechanism of MSC senescence. To better understand and reverse cellular senescence, this review highlights the underlying mechanisms and signs of MSC cellular senescence, and discusses the strategies to combat aging and cellular senescence. Graphical Abstract

show abstract

“…Cellular senescence is closely related to oxidative stress, cell longevity, and stem cell senescence. 7 …”

Section: Introductionmentioning

confidence: 99%

“…Cellular senescence is closely related to oxidative stress, cell longevity, and stem cell senescence. 7 Cancer is a disease of aging characterized by the incremental accumulation of somatic mutations. 6 Recent therapies targeting aging-related diseases revealed a positive antitumor effect by preventing a senescence-associated secretory phenotype.…”

Section: Introductionmentioning

confidence: 99%

Construction and evaluation of an aging-associated genes-based model for pancreatic adenocarcinoma prognosis and therapies

Zhao

Guan

Xing

2023

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

Objectives: Pancreatic adenocarcinoma (PAAD) is a highly malignant tumor. Despite extensive research, the precise role of aging-related genes in the initiation, microenvironment regulation, and progression of PAAD remains unclear. Methods: Patients with PAAD were selected from the International Cancer Genome Consortium (ICGC), and The Cancer Genome Atlas (TCGA) cohorts and the cell senescence-associated genes were obtained from CellAge. ConsensusClusterPlus was utilized for cluster identification. The least absolute shrinkage and selection operator (LASSO) Cox regression analysis was performed to construct a prognosis prediction model. Results: We identified three clusters (C1, C2, and C3) based on aging-associated gene profiles. The C1 cluster had a shorter overall survival time, advanced clinical grades, lower immune ESTIMATE score, and tumor immune dysfunction and exclusion (TIDE) score than the C3 subgroup. Moreover, signaling pathways for cell cycle activation were enriched in the C1 cluster. We also identified eight hub genes and constructed a risk model. The high cellular senescence-related signature (CSRS) score subtype exhibited poor prognosis, advanced clinical grades, M2 macrophage infiltration, higher immune checkpoint gene expression, and lower immunotherapeutic benefits. Conclusion: Our risk score model shows high prediction accuracy and survival prediction ability in individual clinical prognosis and pre-immunotherapy evaluation.

show abstract

Vegetables and Their Bioactive Compounds as Anti-Aging Drugs

Cited by 23 publications

References 167 publications

Plant‐derived nanovesicles offer a promising avenue for anti‐aging interventions

Plant‐derived nanovesicles offer a promising avenue for anti‐aging interventions

Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting

Construction and evaluation of an aging-associated genes-based model for pancreatic adenocarcinoma prognosis and therapies

Contact Info

Product

Resources

About