Vegetable Purgatives Containing Anthracene Derivatives: Part XI. Further Work on the Aloin-like Substance of<i>Rhamnus purshiana</i> DC

Fairbairn, James; Simić, Svetislav D.

doi:10.1111/j.2042-7158.1960.tb10454.x

Cited by 13 publications

(6 citation statements)

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“…Preliminary studies on the dried bark of this species enabled the identification of anthraquinone derivatives as its major compounds (Curica et al, 2008). Moreover, literature reviews showed that the pharmacological properties of F. alnus and F. purshiana are mainly due to the presence of this class of compounds (Fairbairn & Mital, 1958; Fairbairn & Simic, 1960; Cresseri et al, 1966; WHO, 2004 a , 2004 b ).…”

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confidence: 99%

Contribution of Light and Electron Microscopy to Identification of Bark from Frangula azorica, an Azorean Medicinal Plant

et al. 2015

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Frangula azorica V. Grubow is a Macaronesian flora medicinal plant, endemic from Azores islands and inscribed on the International Union for the Conservation of Nature (IUCN) Red List of Threatened Species. This species, known as "sanguinho," belongs to the family Rhamnaceae, the same as Frangula alnus Mill. and Frangula purshiana (DC.) J. G. Cooper, two widely used official laxative herbal medicines of the western Pharmacopoeias constituted by the dried barks of each species. Morphological and chemical studies on F. azorica dried bark are scarce although it is potentially recognized as a Portuguese laxative herbal medicine. Macroscopically, the bark occurs in quills or nearly flat pieces. A channeled external surface with transversely elongated lenticels is characteristic. When the outer phellem layer is removed, a bright purple inner phellem layer is disclosed. Light and electron microscopy observations revealed flattened phellem cells with slightly thickened walls, cortical parenchyma with secretory ducts and groups of sclereids, phloem with groups of fibers and sheaths of parenchymatous cells containing druses or more frequently prismatic crystals of calcium oxalate, and parenchymatous medullary rays one to three cells wide with spherical starch grains. Observation of these botanical characteristics must be included in quality monographs of F. azorica bark herbal medicine.

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Section: Introductionmentioning

confidence: 99%

Contribution of Light and Electron Microscopy to Identification of Bark from Frangula azorica, an Azorean Medicinal Plant

et al. 2015

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“…Chrysophanol anthrone C-glycoside (Chrysaloin) ( Fig. 3C) has been reported from cascara extracts (Fairbairn & Simic, 1960), but has not as yet been described from Aloe exudates.…”

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“…Barbaloin has also been found in extracts from cascara bark (Rhamnus purshiana DC.) (Fairbairn & Simic, 1960). Following the resolution of A and B stereoisomeric cascarosides it was suggested that barbaloin might be similarly resolved into two diastereomers (Fairbairn, 1964) and this was achieved by HPLC, yielding two substances differing in the configuration of the glucose residue at the C , , carbon atom (Auterhoff, Graff, Eurisch & Alexa, 1980; Grun & Franz, 1979).…”

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The compounds in Aloë leaf exudates: a review

Reynolds

1985

Botanical Journal of the Linnean Society

110

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The drug Bitter Aloes has been used for several thousands of years because of its purgative properties and later several species of the plant have been cultivated for horticultural interest. In addition, many more local therapeutic properties have been recorded. Research has been largely directed towards the physiologically active components during the 50s and 60s. Extensions to this work in the last decade have been made in Germany, Japan and South Africa. Compounds have been characterized from the dried exudate prepared for drug purposes and from a few species. A number of anthraquinones have been recognized both in the free state and as glycosides. Other compounds with phenolic groups include chromones and a phenyl‐pyranone. Chromatographic methods have been developed for recognizing some of these compounds and estimating the levels of those of pharmacological interest. Distribution of some of the compounds among a number of species is described showing that among some groups it has taxonomic significance. The biology of secretion and exudation from Aloë leaves remains largely unknown although fragmentary evidence points to interesting and potentially useful activity in some of the components.

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“…BARBALOIN, 10( 1)-deoxyglucosyl aloe-emodin anthrone, is an important constituent of aloes and has recently been shown to occur in cascara (Rhamnus purshiuna D.C. bark) in the form of glycosides (Fairbairn and Simic, 1960). A method of determining the barbaloin content of these crude drugs would therefore be useful in their evaluation.…”

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The Quantitative Conversion of Barbaloin to Aloe-Emodin and its Application to the Evaluation of Aloes

Fairbairn

Simić

1963

Journal of Pharmacy and Pharmacology

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Vegetable Purgatives Containing Anthracene Derivatives: Part XI. Further Work on the Aloin-like Substance ofRhamnus purshiana DC

Cited by 13 publications

References 2 publications

Contribution of Light and Electron Microscopy to Identification of Bark from Frangula azorica, an Azorean Medicinal Plant

Contribution of Light and Electron Microscopy to Identification of Bark from Frangula azorica, an Azorean Medicinal Plant

The compounds in Aloë leaf exudates: a review

The Quantitative Conversion of Barbaloin to Aloe-Emodin and its Application to the Evaluation of Aloes

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