Vegetable Purgatives Containing Anthracene Derivatives

Fairbairn, James; Friedmann, Carlotta; Ryan, H A

doi:10.1111/j.2042-7158.1958.tb10398.x

Cited by 10 publications

(4 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The cascarosides are probably the most important components. In preliminary experiments we have found them more active biologically than the aloins, which is consistent with the fact that the primary glycosides of senna are more active than the secondary ones (Fairbairn, Friedmann & Ryan, 1958). Furthermore they have a sweet taste in contrast to the aloins, and are therefore preferable pharmaceutically.…”

supporting

confidence: 84%

Estimation of C-glycosides and O-glycosides in cascara (Rhamnus purshiana DC., bark) and cascara extract

Fairbairn

Simić

1964

Journal of Pharmacy and Pharmacology

Self Cite

View full text Add to dashboard Cite

An assay process is described which enables the cascarosides, the aloins and the O‐glycosides of cascara to be estimated separately. The cascarosides are separated from the aloins by partition between water and ethyl acetate; each fraction is then oxidised and hydrolysed by ferric chloride treatment to the free anthraquinones which are determined colorimetrically as aloe‐emodin. The O‐glycosides are determined colorimetrically as emodin after acid hydrolysis. Results show that commercial extracts contain only about half the theoretical amount of C‐glycosides and about quarter of the O‐glycosides and there is a significant breakdown of primary glycosides. These results indicate that decomposition occurs during preparation of the official extract. One commercially available extract, which passed current official standards, was shown by the method to be very deficient in activity. In view of the small proportion of O‐glycosides in commercial extracts a shortened assay process, for cascarosides and aloins only, is described.

show abstract

supporting

confidence: 84%

Estimation of C-glycosides and O-glycosides in cascara (Rhamnus purshiana DC., bark) and cascara extract

Fairbairn

Simić

1964

Journal of Pharmacy and Pharmacology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Pods are hung in bunches in well ventilated shade conditions for I 0-12 days to dry. If stored properly and protected from light, senna leaves, pods or their powder retain their biological activity even after five years (Fairbairn et al 1958). The crop yields 1400 kg of leaves and about 150 kg of pods ha-1 under irrigated conditions; yield under unirrigated conditions is lower, ranging from 500-600 kg of leaves and 80-100 kg of pods (Husain 1992).…”

Section: Harvesting and Yieldmentioning

confidence: 98%

CASSIA ANGUSTIFOLIA, A VERSATILE MEDICINAL CROP

Tripathi¹

1999

International Tree Crops Journal

View full text Add to dashboard Cite

Cassia angustifo/ia (senna), a native plant of Yemen, Somalia and Arabia and now cultivated in other parts of the world, has a variety of medicinal uses in Unani as well as other traditional systems of medicine. The plant is mainly valued for its cathartic properties and is specially useful in habitual constipation. The laxative principles sennoside A and sennoside B, isolated from leaves and pods of senna, constitute important ingredients in purgative medicines. The plant has been investigated for its various chemical constituents and pharmacological properties. Being a hardy species, it can be grown even in saline and rainfed conditions. Cultivation of senna does not require much expense on irrigation, manuring, pesticides, protection and other pre-and postharvesting care. This makes the plant an ideal crop for arid regions where water provision, wasteland development, desertification control, sand dune stabilization are the major challenges. The distribution, medicinal applications, chemical and pharmacological studies and various aspects of senna cultivation are reviewed in this paper.

show abstract

“…The two compounds are emodin 1 (or 8) glucoside sul phate and emodin dianthrone diglucoside sul phate; under very mild acid hydrolysis condi tions they produce the corresponding normal glycosides by loss of sulphate. Fairbairn et al (1958) isolated a glycoside from senna which had an equivalent weight of 620 (sennosides 432) an estimated molecular weight of 1,164 (sennosides 862) and which on mild hydrolysis produced sennoside equivalent to 74% of the original substance. Later work showed that four glucose molecules were present and for convenience we refer to this as P4.…”

Section: Sulphated Glycosidesmentioning

confidence: 99%

Oxalated, Sulphated and Primary Glycosides

Fairbairn¹

1980

Pharmacology

View full text Add to dashboard Cite

Vegetable Purgatives Containing Anthracene Derivatives

Cited by 10 publications

References 5 publications

Estimation of C-glycosides and O-glycosides in cascara (Rhamnus purshiana DC., bark) and cascara extract

Estimation of C-glycosides and O-glycosides in cascara (Rhamnus purshiana DC., bark) and cascara extract

CASSIA ANGUSTIFOLIA, A VERSATILE MEDICINAL CROP

Oxalated, Sulphated and Primary Glycosides

Contact Info

Product

Resources

About