Vecuronium Infusion Requirements in Children During Halothane-N2o, Isoflurane-N2o, and Fentanyl-N2o Anesthesia

Dong, Mai-Li; Woelfel, S. K.; Brandom, Barbara W.; Sarner, J. B.; Cook, David

doi:10.1097/00000542-198909001-01039

Cited by 2 publications

(1 citation statement)

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“…This, however, is not much in evidence when vecuronium is used in children with narcotic N20:02 anaesthesia or in an intensive care se&g (Eldadah & Newth 1989). However, in the presence of halothane or more markedly, of isoflurane a decreased requirement does manifest itself after about 30 min of continuous infusion (Dong et al 1989). In general halothane and isoflurane potentiate the neuromuscular effects of vecuronium; furthermore, isoflurane prolongs its action by about 25% whereas halothane does not affect its duration of action ).…”

Section: Vecuroniummentioning

confidence: 99%

Neuromuscular blocking agents in children

Goudsouzian¹

1991

Pediatric Anesthesia

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This article will review the pharmacology of muscle relaxants in children. The neuromuscular pharmacology of the very young (infants less than one year) will be discussed in the next issue of the Journal. In this review the neuromuscular blocking drugs will be discussed in the order of their duration of action. Swamethonium and the recently developed shortacting mivacurium will be considered, followed by the two intermediate-acting agents vecuronium and atracurium (see Figure 1). The last group to be discussed will be the long-acting compounds (pancuronium, tubocurarine, metocurine, alcuronium, gallamine, doxacurium and pipecuronium) (see Figure 2 and Table 1). SuxamethoniumSwamethonium (succinyldicholine) is still the shortest acting neuromuscular blocking agent and the only depolarizing compound regularly used in children. Determinations of effective doses have shown that the ED95 in children less than 10 years of age is 0.42-0.45 mgkg-'; in older children (more than 11 years) the ED95 is 0.27 mg-kg-' a value comparable to that in adults (ED95 0.29 mgkg-') (Meakin et al.

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Section: Vecuroniummentioning

confidence: 99%