Vector control and entomological capacity for onchocerciasis elimination

Tirados, Iñaki; Thomsen, Edward; Worrall, Eve; Koala, Lassane; Melachio, Tito T; Basáñez, María‐Gloria

doi:10.1016/j.pt.2022.03.003

Cited by 4 publications

(2 citation statements)

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“…In addition to chemoprevention, vector control has been proposed as a complementary intervention strategy to eliminate transmission of onchocerciasis in endemic areas [ 43 ]. Understanding the dynamics of insect vectors in an endemic area is the prerequisite for developing effective strategies to break vector-human contact to implement effective monitoring of onchocerciasis control programs [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Status of Onchocerciasis Elimination in Gabon and Challenges: A Systematic Review

Eyang-Assengone,

Makouloutou-Nzassi,

Mbou-Boutambe

et al. 2023

Microorganisms

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Control and treatment programs (CDTI) have been set up nationally in all endemic countries to overcome the impact of onchocerciasis on the affected populations. However, Gabon must still succeed in setting up real onchocerciasis control programs. Here, various database articles have been used to provide the scientific community with a summary document showing the mapping of this disease in Gabon. The articles dealing with onchocerciasis, animal reservoirs, surveillance, and elimination were analyzed. Results showed that little research has been performed. Most studies are concentrated in one region (The area of Lastourville). In addition, we observed that the distribution of the disease varies significantly across the country. Indeed, specific environments present a hyper-endemicity of the disease, while others are meso and hypo-endemic. So, we found some departments with a prevalence ranging from 0% to over 20%; within them, villages had infection levels comprising 10% to 60%, indicating potential hotspots. Vectors activities were studied in some areas. This paper showed the challenges encountered in the country to eliminate this disease. One solution is a deeper understanding of the disease’s bioecology to establish effective health policies to eliminate onchocerciasis in Gabon effectively.

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Section: Discussionmentioning

confidence: 99%

Status of Onchocerciasis Elimination in Gabon and Challenges: A Systematic Review

Eyang-Assengone,

Makouloutou-Nzassi,

Mbou-Boutambe

et al. 2023

Microorganisms

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“…Complementary vector control has also been proposed. For example, the community-directed vector control method known as ‘slash and clear’, where feasible to implement, can potentially accelerate elimination by decreasing the blackfly population density and biting rates [ 20 , 37 ]. ‘Test and not treat’ strategies to exclude L. loa -infected individuals with heavy microfilaraemia and thus at risk of severe adverse reactions to ivermectin have been trialled successfully [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Can mass drug administration of moxidectin accelerate onchocerciasis elimination in Africa?

Kura,

Milton,

Hamley

et al. 2023

Phil. Trans. R. Soc. B

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Epidemiological and modelling studies suggest that elimination of Onchocerca volvulus transmission (EoT) throughout Africa may not be achievable with annual mass drug administration (MDA) of ivermectin alone, particularly in areas of high endemicity and vector density. Single-dose Phase II and III clinical trials demonstrated moxidectin's superiority over ivermectin for prolonged clearance of O. volvulus microfilariae. We used the stochastic, individual-based EPIONCHO-IBM model to compare the probabilities of reaching EoT between ivermectin and moxidectin MDA for a range of endemicity levels (30 to 70% baseline microfilarial prevalence), treatment frequencies (annual and biannual) and therapeutic coverage/adherence values (65 and 80% of total population, with, respectively, 5 and 1% of systematic non-adherence). EPIONCHO-IBM's projections indicate that biannual (six-monthly) moxidectin MDA can reduce by half the number of years necessary to achieve EoT in mesoendemic areas and might be the only strategy that can achieve EoT in hyperendemic areas. Data needed to improve modelling projections include (i) the effect of repeated annual and biannual moxidectin treatment; (ii) inter- and intra-individual variation in response to successive treatments with moxidectin or ivermectin; (iii) the effect of moxidectin and ivermectin treatment on L3 development into adult worms; and (iv) patterns of adherence to moxidectin and ivermectin MDA. This article is part of the theme issue ‘Challenges in the fight against neglected tropical diseases: a decade from the London Declaration on NTDs’.

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Assessing the impact of adverse reactions associated with ivermectin on the dynamics of onchocerciasis in the Democratic Republic of Congo

Nwankwo

Okereke

Okuonghae

2023

Int. J. Dynam. Control

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Vector control and entomological capacity for onchocerciasis elimination

Cited by 4 publications

References 91 publications

Status of Onchocerciasis Elimination in Gabon and Challenges: A Systematic Review

Status of Onchocerciasis Elimination in Gabon and Challenges: A Systematic Review

Can mass drug administration of moxidectin accelerate onchocerciasis elimination in Africa?

Assessing the impact of adverse reactions associated with ivermectin on the dynamics of onchocerciasis in the Democratic Republic of Congo

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