Vector competence of Malaysian<i>Aedes albopictus</i>with and without<i>Wolbachia</i>to four dengue virus serotypes

Joanne, Sylvia; Vythilingam, Indra; Teoh, Boon‐Teong; Leong, Cherng Shii; Tan, Kian Lam; Wong, Meng-Li; Yugavathy, Nava; AbuBakar, Sazaly

doi:10.1111/tmi.12918

Cited by 17 publications

(6 citation statements)

References 50 publications

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“…aegypti across Malaysia and Borneo (52, 54, 55, 65). Its competence for specific dengue genotypes, its abundance in both rural and urban areas, its biting behaviour and its diverse aquatic habitat may all account for patterns of mosquito-human contact and subsequent transmission in Sabah (48, 66). The presence of natural and artificial larval habitats for Ae.…”

Section: Discussionmentioning

confidence: 99%

Spatial and epidemiologic features of dengue in Sabah, Malaysia

Murphy

Rajahram

Jilip

et al. 2019

Preprint

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3435 In South East Asia, dengue epidemics have increased in size and geographical distribution in 36 recent years. Most studies investigating dengue transmission and control have had an urban 37 focus, while less consideration is currently given to rural settings, or where urban and rural 38 areas overlap. We examined the spatiotemporal distribution and epidemiological 39 characteristics of reported dengue cases in the predominantly rural state of Sabah, in 40 Malaysian Borneo -an area where sylvatic and urban circulation of pathogens are known to 41 intersect. We found that annual dengue incidence rates were spatially variable over the 7-42 year study period from 2010-2016 (state-wide mean annual incidence of 21 cases/100,000 43 people; range 5-42/100,000), but were highest in rural localities in the western districts of 44 the state (Kuala Penyu, Nabawan, Tenom and Kota Marudu). The eastern districts exhibited 45 lower overall dengue rates; however, we noted a concentration of severe (haemorrhagic) 46 dengue cases (44%) in Sandakan and Tawau districts. Dengue incidence was slightly higher 47 for males than females, and was significantly higher for both genders aged between 10 and 48 29 years (24/100,000; p=0.029). The largest ever recorded outbreaks occurred during 2015-49 2016, with the vector Aedes albopictus found to be most prevalent in both urban and rural 50 households (House Index of 64%), compared with Ae. Aegypti (15%). These findings suggest 51 that dengue outbreaks in Sabah are driven by the sporadic expansion of dengue virus in both 52 urban and rural settings. This may require tailoring of preventative strategies to suit 53 different transmission ecologies across Sabah. Further studies to better understand the 54 drivers of dengue in Sabah may aid dengue control efforts in Malaysia, and more broadly in 55 South East Asia.3 56 Author summary 57 58 In order to combat the rising regional incidence of dengue in South East Asia, the drivers of 59 transmission must be better characterised across different environmental settings. We 60 conducted the first retrospective analysis of dengue epidemiology in the predominantly rural 61 state of Sabah, Malaysia, where both urban and sylvatic transmission cycles exist. Human 62 notification data over a 7-year period were reviewed and spatiotemporal and demographic 63 risk factors identified. We found: 64 1. Urban habitats and population density are not the only determinants mediating the 65 spread of epidemic dengue in Sabah. Case from both urban and rural localities 66 contributed equally to dengue outbreaks. 67 2. Human demographic risk factors included being aged between 10 and 29 years, and 68 being male. 69 3. High incidence areas for dengue do not predict the occurrence of severe dengue. Severe 70 dengue was largely localised to lower incidence districts in the east of the state. 71 4. The sole presence of Aedes albopictus in and around the majority of urban and rural 72 case households suggests that this vector may play a major role in facilitating outbr...

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Section: Discussionmentioning

confidence: 99%

Spatial and epidemiologic features of dengue in Sabah, Malaysia

Murphy

Rajahram

Jilip

et al. 2019

Preprint

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“…Given the number of DENVs outbreaks and epidemics that have taken place in Cuba (reviewed in [2]), it was also expected to find higher TRs with the DENV-1 strain assayed. However, DENVs also include other serotypes and the vector competence of Cuban populations for these may differ as seen elsewhere [26,27]. Hence, further studies should be conducted to estimate the vector competence of Cuban mosquitoes to the other DENV serotypes.…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

Vector competence of Aedes aegypti from Havana, Cuba, for dengue virus type 1, chikungunya, and Zika viruses

et al. 2020

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Background Like many countries from the Americas, Cuba is threatened by Aedes aegypti-associated arboviruses such as dengue (DENV), Zika (ZIKV), and chikungunya (CHIKV) viruses. Curiously, when CHIKV was actively circulating in the region in 2013–2014, no autochthonous transmission of this virus was detected in Havana, Cuba, despite the importation of chikungunya cases into this city. To investigate if the transmission ability of local mosquito populations could explain this epidemiological scenario, we evaluated for the first time the vector competence of two Ae. aegypti populations (Pasteur and Párraga) collected from Havana for dengue virus type 1 (DENV-1), CHIKV, and ZIKV. Methodology/Principal findings Mosquito populations were fed separately using blood containing ZIKV, DENV-1, or CHIKV. Infection, dissemination, and transmission rates, were estimated at 3 (exclusively for CHIKV), 7, and 14 days post exposure (dpe) for each Ae. aegypti population-virus combination. Both mosquito populations were susceptible to DENV-1 and ZIKV, with viral infection and dissemination rates ranging from 24–97% and 6–67% respectively. In addition, CHIKV disseminated in both populations and was subsequently transmitted. Transmission rates were low (<30%) regardless of the mosquito population/virus combination and no ZIKV was detected in saliva of females from the Pasteur population at any dpe. Conclusions/Significance Our study demonstrated the ability of Ae. aegypti from Cuba to transmit DENV, ZIKV, and CHIKV. These results, along with the widespread distribution and high abundance of this species in the urban settings throughout the island, highlight the importance of Ae. aegypti control and arbovirus surveillance to prevent future outbreaks.

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“…(19)–(28)). For simplicity, we neglect spatial dynamics 42,43 , temperature driven parameter fluctuations 41,44 , inapparent infections 45,46 , non-linearity in bite rates 47–49 , multiple serotypes 50–52 and multi-annual cyclicity 50,53 . Parameters (Supplementary Table 2) reflect transmission within 1 ha accommodating 50 susceptible humans.…”

Section: Resultsmentioning

confidence: 99%

Biopesticides improve efficiency of the sterile insect technique for controlling mosquito-driven dengue epidemics

Pleydell

Bouyer

2019

Commun Biol

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Various mosquito control methods use factory raised males to suppress vector densities. But the efficiency of these methods is currently insufficient to prevent epidemics of arbovirus diseases such as dengue, chikungunya or Zika. Suggestions that the sterile insect technique (SIT) could be “boosted” by applying biopesticides to sterile males remain unquantified. Here, we assess mathematically the gains to SIT for Aedes control of either: boosting with the pupicide pyriproxifen (BSIT); or, contaminating mosquitoes at auto-dissemination stations. Thresholds in sterile male release rate and competitiveness are identified, above which mosquitoes are eliminated asymptotically. Boosting reduces these thresholds and aids population destabilisation, even at sub-threshold release rates. No equivalent bifurcation exists in the auto-dissemination sub-model. Analysis suggests that BSIT can reduce by over 95% the total release required to circumvent dengue epidemics compared to SIT. We conclude, BSIT provides a powerful new tool for the integrated management of mosquito borne diseases.

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Vector competence of MalaysianAedes albopictuswith and withoutWolbachiato four dengue virus serotypes

Cited by 17 publications

References 50 publications

Spatial and epidemiologic features of dengue in Sabah, Malaysia

Spatial and epidemiologic features of dengue in Sabah, Malaysia

Vector competence of Aedes aegypti from Havana, Cuba, for dengue virus type 1, chikungunya, and Zika viruses

Biopesticides improve efficiency of the sterile insect technique for controlling mosquito-driven dengue epidemics

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