VeClose trial 12-month outcomes of cyanoacrylate closure versus radiofrequency ablation for incompetent great saphenous veins

Abstract

In patients with incompetent GSVs, treatment with both CAC and RFA results in high occlusion rates. Time to complete occlusion was faster with CAC, and freedom from reopening was higher after CAC. Quality of life scores improved equally with both therapies.

A Randomised Clinical Trial Comparing N-Butyl Cyanoacrylate, Radiofrequency Ablation and Endovenous Laser Ablation for the Treatment of Superficial Venous Incompetence: Two Year Follow up Results

“…The only randomised clinical trial to compare NBCA and RFA was the VeClose trial. 11,22 Occlusion rates in these studies were similar. However, these studies comparing NBCA with RFA or EVLA involved one 0 (0,0%) 20 (13,4%) 10 (7,2%) 4 or later b 0 (0,0%) 1 (0,7%) 0 (0,0%) NBCA ¼ N-butyl cyanoacrylate; RFA ¼ radiofrequency ablation; EVLA ¼ endovenous laser ablation.…”

Efficacy of Cyanoacrylate Glue Ablation of Primary Truncal Varicose Veins Compared to Existing Endovenous Techniques: A Systematic Review of the Literature

“…2 "Thrombophlebitis" and "abnormal skin reactions" in treatment zones were included with the general term "phlebitis." 12,13 All thrombus extensions into the deep venous systems were classified as deep vein thromboses (DVTs). Complications common to the three ablation modalities were evaluated.…”

“…Comparison of NBCA with RFA and/or EVLA was performed in three RCTs and two retrospective studies. 10,12,19,21,22 No studies compared NBCA with sclerotherapy, but this was frequently used an adjunctive treatment. Levels of evidence for therapeutic studies were judged using criteria from the Centre for Evidence-Based Medicine.…”

“…10 Randomization was better in the VeClose trial and the study by Eroglu and Yasim. 1,12,19 The former also included "roll-in cases" so that investigators could achieve familiarity with the NBCA procedure. DUS assessments were not always performed by blinded personnel.…”

“…27 The rest utilized the VenaSeal system (Medtronic, Dublin, Ireland). 12,13,21,25,26,28,[32][33][34] All procedures commenced by cannulation of the target vein with an introducer needle under ultrasound guidance at the most distal point of reflux. The position of the delivery catheter tip distal to SFJ or SPJ ranged from 3 to 5 cm.…”