VDR microRNA expression and epigenetic silencing of vitamin D signaling in melanoma cells

Essa, Salma; Denzer, Nicole; Mahlknecht, Ulrich; Klein, Rolf Michael; Collnot, Eva-Maria; Tilgen, Wolfgang; Reichrath, Jörg

doi:10.1016/j.jsbmb.2010.02.003

Cited by 80 publications

(71 citation statements)

References 13 publications

(21 reference statements)

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“…59 For melanoma cell lines A375 and Mel-Juso antiproliferative effects mediated by epigenetic mechanisms could be demonstrated. 60,61 This could also contribute to the observed phenotypes of the cells. However, for Mel-Juso-L3 and A2058 to our knowledge no data exist concerning epigenetic effects on cellular responses.…”

Section: Discussionmentioning

confidence: 97%

Irradiation affects cellular properties and Eph receptor expression in human melanoma cells

Mosch

Pietzsch²,

Pietzsch³

2012

Cell Adhesion & Migration

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Section: Discussionmentioning

confidence: 97%

Irradiation affects cellular properties and Eph receptor expression in human melanoma cells

Mosch

Pietzsch²,

Pietzsch³

2012

Cell Adhesion & Migration

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“…Vitamin D supplementation is now being investigated in the treatment and prevention of these diseases, with a particular focus on its potential as a cancer chemopreventative, due to the identified role of the vitamin D receptor (VDR) in cell-cycle regulation and differentiation (86) . The active vitamin D metabolite, calcitriol (1,25-dihydroxyvitamin D 3 ), has long been known to directly (50) Choline deficiency (114) , methyl group deficiency (112) 126 (49) Vitamin C deficiency (131) 152 (118) Retinoic acid treatment (118) DNMT3 29 (47,48) Folate/methyl group deficiency (108) , retinoic acid treatment (123) 222 (95) Vitamin D treatment (90) Histone methyltransferase SUV39H1 125b (57) Vitamin E deficiency (142) , retinoic acid treatment (117,120) , vitamin D treatment (89) HDAC and HAT 206 (64) Retinoic acid treatment (117,120) 22 (94) Vitamin D treatment (92) HDAC 627 (96) Vitamin D treatment (96) DNMT, DNA-methyl transferase; HDAC, histone deacetylase; HAT, histone acetyltransferase.…”

Section: Vitamin Dmentioning

confidence: 99%

The role of vitamins and minerals in modulating the expression of microRNA

et al. 2014

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A growing number of studies in recent years have highlighted the importance of molecular nutrition as a potential determinant of health and disease. In particular, the ability of micronutrients to regulate the final expression of gene products via modulation of transcription and translation is now being recognised. Modulation of microRNA (miRNA) by nutrients is one pathway by which nutrition may mediate gene expression. miRNA, a class of non-coding RNA, can directly regulate gene expression post-transcriptionally. In addition, miRNA are able to indirectly influence gene expression potential at the transcriptional level via modulation of the function of components of the epigenetic machinery (DNA methylation and histone modifications). These mechanisms interact to form a complex, bi-directional regulatory circuit modulating gene expression. Disease-specific miRNA profiles have been identified in multiple disease states, including those with known dietary risk factors. Therefore, the role that nutritional components, in particular, vitamins and minerals, play in the modulation of miRNA profiles, and consequently health and disease, is increasingly being investigated, and as such is a timely subject for review. The recently posited potential for viable exogenous miRNA to enter human blood circulation from food sources adds another interesting dimension to the potential for dietary miRNA to contribute to gene modulation.

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“…koža, mozog, srdce, obličky, prištítne telieska, tenké a hrubé črevo, NK bunky), čo pou- [15]. Opačnú úlohu zastáva ligandom 1α,25(OH) 2 D 3 aktivovaný vysokoexprimovaný VDR, na ktorý sa v rakovinových bunkách viaže kalcitriol (aktívny vitamín D 3 ) a tým aktivuje anti-tumorovú signalizačnú dráhu s dokázanými anti-proliferatívnymi účinkami na rakovinové bunky [16,17]. výskytu MM.…”

Section: Vitamín D 3 a Väzba Na Vdrunclassified

“…Halsall et al [13] identifikovali kombinovaný efekt melanó-mového rizika A alely v EcoRV (A-1012G) polymorfi zme s alelou vo FokI polymorfi zme. Podobne progresia melanómu by mohla byť klasifi kovaná detekciou v signalizácií vitamínu D, založenej na znížení expresie VDR [14]. Analýza expresie VDR a polymorfi zmov, môže poskytnúť veľmi kazuje na široké spektrum využitia s cieľom na ovplyvnenia veľkého množstva analytov tak za fyziologických, ako aj patologických stavov organizmu.…”

Section: Vitamín D 3 a Väzba Na Vdrunclassified

Effect of Vitamin D Receptor Polymorphisms on the Development and Progression of Malignant Melanoma

Špaková¹,

Rabajdová²,

Zábavníková³

et al. 2014

Klin Onkol

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1 Ústav lekárskej a klinickej bio chémie LF UPJŠ a LABMED, a. s., Košice 2 Klinika plastickej, rekonštrukčnej a estetickej chirurgie LF UPJŠ a UN LP Košice SúhrnVýchodiská: Malígny melanóm patrí k najzhubnejším nádorovým ochoreniam zo všetkých ná-dorov kože mužov aj žien. Pravdepodobnosť vzniku malígneho melanómu závisí od vplyvu vonkajších faktorov a vzájomnej deregulácii interakcií genotypu a fenotypu. V súčasnosti sa čoraz väčšia pozornosť venuje štúdiu interakcií aktívnej formy vitamínu D 3 s receptorom, ako aj inhibičnému účinku polymorfi zmov receptoru vitamínu D 3 na viaceré signálne dráhy zapojené do proliferačných a metastatických procesov. Ciele: Táto prehľadová práca sa zameriava na popísanie vzťahu medzi faktormi, ktoré pôsobia na vznik maligného melanómu ovplyvnením Hedgehog signálnej dráhy (HH). Sumarizuje súčasné poznatky zaoberajúce sa malígnym melanómom v spojení s úlohou aktívnej formy vitamínu D 3 pri väzbe na receptor vitamínu D 3 (VDR) a vplyvu polymorfi zmov VDR na inhibíciu HH. Pochopenie daných mechanizmov a kritické zhodnotenie poznatkov sú dôležité pre aplikáciu primárnej, ako aj sekundárnej prevencie, respektíve pri použití chemoprevenčných látok vhodných pre predchádzanie vzniku malígneho melanómu. Kľúčové slová vitamín D 3 -Hedgehog signalizácia -melanóm -kalcitriol -rakovina kože SummaryBackground: Malignant melanoma is one of the most aggressive cutaneous tumors in men and women. The risk of developing a malignant melanoma depends on several external factors along with deregulation of mutual interaction of genotype and phenotype. Nowadays, growing attention is focused on the study of the interactions of the active form of vitamin D 3 with its receptor and inhibitory eff ect of vitamin D 3 receptor polymorphisms on multiple signaling pathways involved in proliferative and metastatic processes. Objectives: This review article addresses the relationship between factors involved in the development of malignant melanoma through Hedgehog signaling pathway (HH). It summarizes current knowledge of malignant melanoma in regard to the role of the active form of vitamin D 3 binding to vitamin D 3 receptor (VDR), as well as it describes the infl uence of polymorphisms of VDR on the inhibition of HH. Understanding of these mechanisms and critical assessment of available data is benefi cial to both primary and secondary prevention of malignant melanoma particularly by means of chemo-preventive substances.

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VDR microRNA expression and epigenetic silencing of vitamin D signaling in melanoma cells

Cited by 80 publications

References 13 publications

Irradiation affects cellular properties and Eph receptor expression in human melanoma cells

Irradiation affects cellular properties and Eph receptor expression in human melanoma cells

The role of vitamins and minerals in modulating the expression of microRNA

Effect of Vitamin D Receptor Polymorphisms on the Development and Progression of Malignant Melanoma

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