VCP/Cdc48 rescues the growth defect of a <i>GPI10</i> mutant in yeast

Ohnuma, Yohei; Takata, Takahiro; Kawawaki, Junko; Yasuda, Kouji; Tanaka, Keiji; Kimura, Yoko; Kakizuka, Akira

doi:10.1016/j.febslet.2015.01.017

Cited by 1 publication

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“…Overexpression of Cdc48, an AAA (ATPase associated with various cellular activities) ATPase, could rescue the growth defect and partially reverse UPR in gpi10 but could not reverse its CW defects or sensitivity to CW stressors . Cdc48 was initially identified for its role in the cell cycle and is known to affect G1 progression as well as other cellular activities including proteasome‐mediated protein degradation, ubiquitin‐dependent processes, and endosomal protein trafficking (reviewed in ).…”

Section: Addition Of Man and Etnp Residuesmentioning

confidence: 99%

Generating anchors only to lose them: The unusual story of glycosylphosphatidylinositol anchor biosynthesis and remodeling in yeast and fungi

et al. 2018

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Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) are present ubiquitously at the cell surface in all eukaryotes. They play a crucial role in the interaction of the cell with its external environment, allowing the cell to receive signals, respond to challenges, and mediate adhesion. In yeast and fungi, they also participate in the structural integrity of the cell wall and are often essential for survival. Roughly four decades after the discovery of the first GPI-APs, this review provides an overview of the insights gained from studies of the GPI biosynthetic pathway and the future challenges in the field. In particular, we focus on the biosynthetic pathway in Saccharomyces cerevisiae, which has for long been studied as a model organism. Where available, we also provide information about the GPI biosynthetic steps in other yeast/ fungi. Although the core structure of the GPI anchor is conserved across organisms, several variations are built into the biosynthetic pathway. The present Review specifically highlights these variations and their implications. There is growing evidence to suggest that several phenotypes are common to GPI deficiency and should be expected in GPI biosynthetic mutants. However, it appears that several phenotypes are unique to a specific step in the pathway and may even be species-specific. These could suggest the points at which the GPI biosynthetic pathway intersects with other important cellular pathways and could be points of regulation. They could be of particular significance in the study of pathogenic fungi and in identification of new and specific antifungal drugs/ drug targets. © 2018 IUBMB Life, 70(5):355-383, 2018.

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Section: Addition Of Man and Etnp Residuesmentioning

confidence: 99%