VCAM-1 Values in Obese Adolescents with Dyslipidemia and Insulin Resistance

Abstract

Background: The incidence of obesity in adolescents in the world is increasing. Obesity can lead to atherosclerosis, which is initially accompanied by endothelial dysfunction. Methods: This study cros sectional study conducted from Februari to September 2021 in Surabaya, indonesia. VCAM-1 was examined in the Institute Tropical Diseases (ITD) laboratory using ELISA methods. Result: One hundred and sixteen children are included in this study, consisting of 107 obese children and 9 non-obese children. The VCAM-1 values in obese adolescents increased 2.4x compared to those in non-obese adolescents (p-value 0.001). The VCAM-1 values in obese adolescents without dyslipidemia nor insulin resistance increased 2.4x (p-value 0.001), in obese adolescents who had dyslipidemia it increased 2.2x (p-value 0.001), in obese adolescents who had insulin resistance it increased 1.8x (p-value 0.007), and in obese adolescents who had dyslipidemia and insulin resistance it increased 2.5x (p-value 0.007) compared to those in non-obese adolescents without dyslipidemia nor insulin resistance. There was no significant difference in the VCAM-1 values neither in obese adolescents who had dyslipidemia (p-value 0.377), in obese adolescents who had insulin resistance (p-value 0.174), nor obese adolescents who had dyslipidemia and insulin resistance (p-value 0.769) compared to those in obese adolescents who had no dyslipidemia nor insulin resistance.