Objectives-To investigate the occurrence of disorders associated with the hand arm vibration syndrome in a large population of stone workers in Italy. The dose-response relation for vibration induced white finger (VWF) was also studied. Methods-The study population consisted of 570 quarry drillers and stonecarvers exposed to vibration and 258 control stone workers who performed only manual activity. Each subject was interviewed with health and workplace assessment questionnaires. Sensorineural and VWF disorders were staged according to the Stockholm workshop scales. Vibration was measured on a representative sample of percussive and rotary tools. The 8 h energy equivalent frequency weighted acceleration (A (8)) and lifetime vibration doses were calculated for each of the exposed stone workers. Results-Sensorineural and musculoskeletal symptoms occurred more frequently in the workers exposed to vibration than in the controls, but trend statistics did not show a linear exposureresponse relation for these disorders. The prevalence of VWF was found to be 30'2% in the entire group exposed to vibration. Raynaud's phenomenon was discovered in 4*3% of the controls. VWF was strongly associated with exposure to vibration and a monotonic dose-response relation was found. According to the exposure data of this study, the expected percentage of stone workers affected with VWF tends to increase roughly in proportion to the square root of A (8) Adverse health effects resulting from the use of vibrating tools in the stone industry have been reported since the beginning of this century. In 191 1, Giovanni Loriga, an Italian physician, first described the occurrence of episodes of tingling, numbness, and whiteness in the fingers and hands of stone and marble cutters and carvers who used barrel shaped air hammers without a handle and throttle valve.' Later in 1918, Alice Hamilton reported that 89-5% of 38 limestone cutters of Bedford, Indiana, United States, had attacks of finger blanching (defined as "spastic anemia affecting the arterioles of the fingers and hands")2 resembling the digital ischaemic phenomenon described by the French physician Maurice Raynaud in 1862. A personal review of the available scientific literature showed that in the last 80 years about 20 epidemiological surveys of vibration induced disorders among stone workers have been performed. [1][2][3][4][5][6][7][8][9][10][11][12] Italy produces more stone than any other country in the world (7-2 million tons in 1991). In Italy great varieties of ornamental stones such as marble, travertine, porphyry, granite, and serpentine are excavated in the quarries and processed in the mills. In recent decades there has been limited implementation of technical measures aimed at reducing the risk from exposure to excessive vibration in the stone industry. Taylor et al who revisited the limestone quarries of Bedford after a 60 year interval,7 found that no change in the design of the air hammers used by the stonecutters had taken place since the 1918 Hamilton su...