VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia

Egle, Alexander; Harris, Alan W.; Bath, Mary L.; O’Reilly, Lorraine A.; Cory, Suzanne

doi:10.1182/blood-2003-07-2469

Cited by 199 publications

(213 citation statements)

References 36 publications

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“…The first transgenic mice utilized B lymphoid-specific transgenes (El-bcl-2) and induced plasmacytomas (64,65) while the transgene with pan-hematopoietic Bcl-2 expression (VavP-bcl-2) produced follicular lymphoma (66). It is interesting to note that overexpression of Bcl-2 only produced these tumor types after a long latency and required an additional oncogene such as Myc to fully develop lymphoma (67).…”

Section: Role In Tumorigenesismentioning

confidence: 99%

Bcl‐2 family proteins: The sentinels of the mitochondrial apoptosis pathway

2008

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SummaryBcl-2 family members are the arbiters of mitochondrial apoptotic pathway, which is conserved through evolution. The stoichiometry of pro-versus antiapoptotic Bcl-2 family members in the cell determines whether the cell lives or dies. This fine balance is regulated at the transcriptional or posttranslational level in response to various cellular cues. These signals are transmitted through the upstream molecules in the pathway, that is, the BH3-only molecules that results in the activation of the adaptor molecules, Bax and Bak, at the mitochondrial surface ensuing mitochondrial dysfunction and apoptosis. Understanding the activation process offers a great potential in the therapeutic intervention of many diseases such as cancer and autoimmune disorders.2008 IUBMB IUBMB Life, 60(6): [390][391][392][393][394][395][396][397] 2008

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Section: Role In Tumorigenesismentioning

confidence: 99%

Bcl‐2 family proteins: The sentinels of the mitochondrial apoptosis pathway

2008

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“…In these mice, mature isotype-switched lymphomas developed, B45% of these lymphomas were cytologically reminiscent of FL but still lacked the typical follicular architecture. 135 Double Em-bcl-2/myc transgenic mice generated lymphomas much faster than both single Em-bcl-2 and single Em-myc transgenic mice. The lymphomas in double Em-bcl-2/myc transgenic mice consist most often of mIgM À lymphoblastic cells in which c-myc initiates robust proliferation, most likely the proapoptotic properties of c-myc are inhibited by bcl-2.…”

Section: Mouse Models Of Lymphomagenesismentioning

confidence: 99%

Molecular pathways in follicular lymphoma

2006

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Follicular lymphoma (FL) is one of the most common B-cell non-Hodgkin's lymphomas. The initiating genetic event found in B90% of FL is the t(14;18), causing constitutive expression of the antiapoptotic BCL-2 protein. The exact secondary alterations leading to full FL development are still poorly defined. In this review, we address (i) the genetic pathways associated with tumorigenesis and progression of FL, (ii) the role of micro-environmental factors with emphasis on B-cell receptor ligands and (iii) lymphoma models in mice and what they teach us about lymphomagenesis in man.

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“…Interestingly, mice overexpressing bcl2 under the E enhancer are not susceptible to follicular lymphoma but, instead, develop a range of B-lymphoid malignancies, including pre-B-cell lymphomas and plasmacytomas (31). However, follicular lymphoma, with an incidence of up to 50% by 18 months of age, can be simulated in mice by overexpressing bcl2 under the panhematopoietic promoter, vav (32,33). This represents an animal model for bcl2-induced human follicular lymphoma.…”

Section: Mlh Loss Accelerates B-cell Lymphomagenesis In Pfp-deficientmentioning

confidence: 99%