Vault packaged enzyme mediated degradation of amino-aromatic energetic compounds

Lothe, Anjali G.; Kalra, Shashank Singh; Wang, Meng; Mack, E. Erin; Walecka-Hutchison, Claudia; Kickhoefer, Valerie A.; Rome, Leonard H.; Mahendra, Shaily

doi:10.1016/j.chemosphere.2019.125117

Cited by 13 publications

(3 citation statements)

References 40 publications

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“…The enzymatic repertoire of Trametes versicolor, in particular, has demonstrated remarkable efficacy in degrading diverse pollutants, including pesticides [249,250], hospital waste [251], and therapeutic composites [252], among others [247]. Furthermore, Ganoderma lucidum, Phanerochaete chrysosporium, and Pleurotus ostreatus have demonstrated outstanding enzymatic capabilities in the process of bioremediating various pollutants [253,254]. However, the current market prices of these enzymes remain prohibitively high for large-scale environmental applications [248].…”

Section: Bioremediationmentioning

confidence: 99%

The Role of Microbial Diversity in Lignocellulosic Biomass Degradation: A Biotechnological Perspective

Rasool,

Irfan

2024

ChemBioEng Reviews

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Lignocellulosic biomass, such as plant residues and agricultural waste, holds immense potential as a renewable resource for the production of biofuels, chemicals, and animal feed. However, the efficient degradation of lignocellulose into fermentable sugars remains a significant challenge. Recent research has highlighted the critical role of microbial diversity in lignocellulosic biomass degradation, offering new insights from a biotechnological perspective. The comprehension and utilization of microbial diversity are crucial for developing efficient biotechnological strategies for lignocellulosic biomass degradation. By uncovering the intricate relationships between microbial communities and their enzymatic machinery, researchers can optimize degradation processes, enhance biofuel production, and contribute to a more sustainable bio‐based economy. Microorganisms, including bacteria, fungi, and archaea, possess diverse enzymatic capabilities, allowing them to secrete a plethora of lignocellulolytic enzymes. Microbial organisms inhabiting extreme environments, such as the rumen, hot and cold springs, deep sea trenches, and acidic and alkaline pH environments, exhibit significant potential in generating enzymes, including hemicellulolytic and lignocellulolytic enzymes, which possess superior biochemical properties essential for industrial bioconversion applications. This review explores the ability of lignocellulosic enzymes from microbial sources to efficiently break down the lignocellulosic biomass and their potential applications in industrial biotechnology.

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Section: Bioremediationmentioning

confidence: 99%

The Role of Microbial Diversity in Lignocellulosic Biomass Degradation: A Biotechnological Perspective

Rasool,

Irfan

2024

ChemBioEng Reviews

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“…Enzymes produced from Trametes versicolor , for example, showed enormous potential in the degradation of several types of pesticides [ 317 , 321 , 322 ], hospital waste [ 323 ], and pharmaceutical compounds [ 324 ], among others [ 320 ]. In addition to this, species such as Pleurotus ostreatus, Phanerochaete chrysosporium, and Ganoderma lucidum also demonstrate excellent enzymatic activities for different pollutants bioremediation [ 325 , 326 , 327 , 328 , 329 , 330 ]. However, current commercial prices of such enzymes are still too high for mass environmental applications [ 319 ].…”

Section: Application Of Lignocellulolytic Enzymesmentioning

confidence: 99%

Lignocellulolytic Biocatalysts: The Main Players Involved in Multiple Biotechnological Processes for Biomass Valorization

Benatti

Polizeli

2023

Microorganisms

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Human population growth, industrialization, and globalization have caused several pressures on the planet’s natural resources, culminating in the severe climate and environmental crisis which we are facing. Aiming to remedy and mitigate the impact of human activities on the environment, the use of lignocellulolytic enzymes for biofuel production, food, bioremediation, and other various industries, is presented as a more sustainable alternative. These enzymes are characterized as a group of enzymes capable of breaking down lignocellulosic biomass into its different monomer units, making it accessible for bioconversion into various products and applications in the most diverse industries. Among all the organisms that produce lignocellulolytic enzymes, microorganisms are seen as the primary sources for obtaining them. Therefore, this review proposes to discuss the fundamental aspects of the enzymes forming lignocellulolytic systems and the main microorganisms used to obtain them. In addition, different possible industrial applications for these enzymes will be discussed, as well as information about their production modes and considerations about recent advances and future perspectives in research in pursuit of expanding lignocellulolytic enzyme uses at an industrial scale.

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“…For instance, manganese peroxidase has been encapsulated in vault NPs and is being studied for biodegradation of organic contaminants [102]. Enzymes can be encapsulated within these structures, leading to enhanced stability [102,103] and, when coupled with target-directing molecules such as monoclonal antibodies, can be delivered efficiently to the desired region [104]. On the other hand, virosomes are produced based on some features from viruses to improve the delivery of drugs during enzyme treatments.…”

Section: Encapsulation Of Enzymesmentioning

confidence: 99%

Enzyme Therapy: Current Challenges and Future Perspectives

Fuente

Lombardero²,

Gómez-González

et al. 2021

IJMS

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In recent years, enzymes have risen as promising therapeutic tools for different pathologies, from metabolic deficiencies, such as fibrosis conditions, ocular pathologies or joint problems, to cancer or cardiovascular diseases. Treatments based on the catalytic activity of enzymes are able to convert a wide range of target molecules to restore the correct physiological metabolism. These treatments present several advantages compared to established therapeutic approaches thanks to their affinity and specificity properties. However, enzymes present some challenges, such as short in vivo half-life, lack of targeted action and, in particular, patient immune system reaction against the enzyme. For this reason, it is important to monitor serum immune response during treatment. This can be achieved by conventional techniques (ELISA) but also by new promising tools such as microarrays. These assays have gained popularity due to their high-throughput analysis capacity, their simplicity, and their potential to monitor the immune response of patients during enzyme therapies. In this growing field, research is still ongoing to solve current health problems such as COVID-19. Currently, promising therapeutic alternatives using the angiotensin-converting enzyme 2 (ACE2) are being studied to treat COVID-19.

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Vault packaged enzyme mediated degradation of amino-aromatic energetic compounds

Cited by 13 publications

References 40 publications

The Role of Microbial Diversity in Lignocellulosic Biomass Degradation: A Biotechnological Perspective

The Role of Microbial Diversity in Lignocellulosic Biomass Degradation: A Biotechnological Perspective

Lignocellulolytic Biocatalysts: The Main Players Involved in Multiple Biotechnological Processes for Biomass Valorization

Enzyme Therapy: Current Challenges and Future Perspectives

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